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Internalization and degradation of EGF receptor

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Book cover EGFR Signaling Networks in Cancer Therapy

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Activation of the EGF receptor (EGFR) at the cell surface results in acceleration of endocytosis of the receptor and rapid degradation of endocytosed receptors in lysosomes. The elevated internalization and lysosomal targeting result in down-regulation of the EGFR, which negatively regulates signaling by the receptor. This review describes the molecular mechanisms involved in EGFR trafficking, which lead to growth-factor-induced receptor down-regulation.

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Acknowledgements

I thank Dr. Jason Duex and Ms. Melissa Adams for critical reading of the manuscript. This work was supported by NCI grant CA08915 and ACS grant RSG-00-247-04-CSM.

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  1. Department of Pharmacology, University of Colorado Health Sciences Center at Fitzsimmons, Mail Stop 8303, P.O. Box 6511, 80045-0508, Aurora, CO

    Alexander Sorkin PhD

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  1. OSI Pharmaceuticals, Inc., Bioscience Park Drive 1, Farmingdale, 11735, U.S.A.

    John D. Haley

  2. Dept. Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, United Kingdom

    William John Gullick

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Sorkin, A. (2008). Internalization and degradation of EGF receptor. In: Haley, J., Gullick, W. (eds) EGFR Signaling Networks in Cancer Therapy. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-356-1_4

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