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The Role of Microtubules in Cell Biology, Neurobiology, and Oncology pp 47–81Cite as

Microtubule Dynamics

Mechanisms and Regulation by Microtubule-Associated Proteins and Drugs In Vitro and in Cells

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Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Microtubules are dynamic cellular polymers. Their dynamics are exquisitely regulated and are essential to many cellular activities including mitosis, cell division, signaling, adhesion, directed migration, polarization, vesicle and protein delivery to and retrieval from the plasma membrane, and remodeling of cell shape and organization. The cytoskeleton, which includes microtubules, actin filaments, and intermediate filaments (such as vimentin, lamin, and keratin) is not a stable structure, but is a continuously evolving machine. The machine remakes or reorganizes itself in response to outside signals regulating cell activities (1). In Subheading 1, the authors describe the dynamic behaviors of microtubules in vitro with purified microtubules, their mechanisms, and some of the many ways that dynamics are modulated by microtubule-targeted drugs and endogenous cellular regulators. In Subheading 2, the authors describe microtubule dynamics and their regulation in living cells.

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Authors and Affiliations

  1. Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA

    Mary Ann Jordan PhD & Leslie Wilson PhD

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  1. Mary Ann Jordan PhD
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  2. Leslie Wilson PhD
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  1. Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD

    Tito Fojo MD, PhD

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© 2008 Humana Press, Totowa, NJ

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Jordan, M.A., Wilson, L. (2008). Microtubule Dynamics. In: Fojo, T. (eds) The Role of Microtubules in Cell Biology, Neurobiology, and Oncology. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-336-3_3

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  • DOI: https://doi.org/10.1007/978-1-59745-336-3_3

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