Summary
Historically, saliva or oral fluid has been tested for monitoring therapeutic drugs. Drugs-of-abuse, including cannabinoids, opioids, amphetamines, and cocaine, have been detected in this matrix. Multiple collection procedures and devices are available. The route of administration, collection procedures, and saliva : plasma ratios affect the amount of drug deposited. However, current analytical techniques may be utilized for testing provided the relevant compound is targeted. The window of detection is comparable to blood and is therefore conducive to detecting recent drug use.
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Spiehler, V., Cooper, G. (2008). Drugs-of-Abuse Testing in Saliva or Oral Fluid. In: Jenkins, A.J., Caplan, Y.H. (eds) Drug Testing in Alternate Biological Specimens. Forensic Science And Medicine. Humana Press. https://doi.org/10.1007/978-1-59745-318-9_5
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DOI: https://doi.org/10.1007/978-1-59745-318-9_5
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