Genomics in Endocrinology pp 219-237

Part of the Contemporary Endocrinology book series (COE) | Cite as

Genomics and Polycystic Ovary Syndrome (PCOS): The Use of Microarray Analysis to Identify New Candidate Genes

  • Jennifer R. Wood
  • Jerome F. StraussIII

Abstract

Transcriptome profiling offers a potentially valuable approach to the identification of candidate genes and pathways that contribute to complex diseases. Here we describe the application of microarray analysis of human theca cells and ovaries to the understanding of the pathophysiology of polycystic ovary syndrome (PCOS), a complex reproductive endocrine and metabolic disorder, and the investigation of selected candidate genes derived from these analyses with respect to association and linkage to PCOS.

Keywords

Polycystic ovary syndrome theca cells steroidogenesis follicle ovary 

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© Humana Press 2008

Authors and Affiliations

  • Jennifer R. Wood
  • Jerome F. StraussIII

There are no affiliations available

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