Abstract
There have been great advances in the past 15 years in our understanding of how blood vessels form and function. Many of these advances result from the availability of several animal models that allow for embryological, molecular, and genetic manipulations of the developing vasculature. Here I describe four vertebrate animal models used in studies of vascular development. The frog, zebrafish, avian, and mouse embryos are compared historically and currently. Recent advances using each model are highlighted. Finally, I describe the use of animal derivatives, the chick chorioallantoic membrane and mouse embryonic stem cells, for studies of blood vessel formation.
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Bautch, V.L. (2008). Animal Models of Vascular Development and Endothelial Cell Biology. In: Conn, P.M. (eds) Sourcebook of Models for Biomedical Research. Humana Press. https://doi.org/10.1007/978-1-59745-285-4_38
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DOI: https://doi.org/10.1007/978-1-59745-285-4_38
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