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Animal Models for Human Diseases

An Overview

  • Chapter
Sourcebook of Models for Biomedical Research

Abstract

This chapter provides an introduction to the concept of laboratory animal models, focusing on a general classification of animal models for the study of human diseases. Animal models can be grouped into one of the following five categories: (1) induced (experimental) models, (2) spontaneous (genetic, mutant) models, (3) genetically modified models, (4) negative models, and (5) orphan models. This is followed by a discussion of how knowledge concerning human biology and pathobiology can be extrapolation from results obtained from studies of animals. Finally the chapter discusses how the difference in body size and metabolic rate between small laboratory animals and humans has an impact on the calculation of relevant doses for animals used as models for humans in experimental studies.

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Authors and Affiliations

  1. Department of Experimental Medicine, University of Copenhagen and Rigshospitalet, The Panum Institute, Copenhagen, N, Denmark

    Jann Hau MD (Chair of Comparative Medicine, Head)

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  1. Jann Hau MD
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Editors and Affiliations

  1. Oregon National Primate Research Center, Beaverton, OR

    P. Michael Conn PhD (Associate Director and Senior Scientist, Professor of Physiology and Pharmacology, Professor of Cell and Developmental Biology) (Associate Director and Senior Scientist, Professor of Physiology and Pharmacology, Professor of Cell and Developmental Biology)

  2. Oregon Health and Science University, Portland, OR

    P. Michael Conn PhD (Associate Director and Senior Scientist, Professor of Physiology and Pharmacology, Professor of Cell and Developmental Biology) (Associate Director and Senior Scientist, Professor of Physiology and Pharmacology, Professor of Cell and Developmental Biology)

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© 2008 Humana Press Inc., Totowa, NJ

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Hau, J. (2008). Animal Models for Human Diseases. In: Conn, P.M. (eds) Sourcebook of Models for Biomedical Research. Humana Press. https://doi.org/10.1007/978-1-59745-285-4_1

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  • DOI: https://doi.org/10.1007/978-1-59745-285-4_1

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-933-8

  • Online ISBN: 978-1-59745-285-4

  • eBook Packages: MedicineMedicine (R0)

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