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Use of Observational Databases (Registries) in Research

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Abstract

The outcomes and costs associated with medical care are critical issues for society. Interventions, treatments, and health care providers are required to be both effective and cost-effective. More and more the cumulative effects of disease, treatment, and outcome are becoming the standard for evaluation of effectiveness and cost-effectiveness. Although randomized clinical trials are the “ gold standard” for comparing alternative treatments, results may not be generalizable to usual clinical care nor reflect treatment effectiveness in community practice. The discrepancy between clinical trials and studies of actual effectiveness has been pointed out a number of times over more than 30 years.

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Author information

Authors and Affiliations

  1. Health Economics and Outcomes Research, Amgen, Thousand Oaks, CA

    Deborah P. Lubeck PhD (Associate Director)

Authors
  1. Deborah P. Lubeck PhD
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Editor information

Editors and Affiliations

  1. Departments of Urology and Preventive Medicine Keck School of Medicine, University of Southern California, Los Angeles, CA

    David F. Penson MD, MPH

  2. Department of Urology, University of Michigan Medical School, Ann Arbor, MI

    John T. Wei MD, MS

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© 2006 Humana Press Inc., Totowa NJ

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Lubeck, D.P. (2006). Use of Observational Databases (Registries) in Research. In: Penson, D.F., Wei, J.T. (eds) Clinical Research Methods for Surgeons. Humana Press. https://doi.org/10.1007/978-1-59745-230-4_6

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  • DOI: https://doi.org/10.1007/978-1-59745-230-4_6

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-326-8

  • Online ISBN: 978-1-59745-230-4

  • eBook Packages: MedicineMedicine (R0)

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