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Focal Liver Ablation Techniques in Primary and Secondary Liver Tumors

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Regional Cancer Therapy

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Focal ablative techniques are promising tools in the treatment of unresectable primary and secondary liver tumors. Despite a lack of randomized controlled trials, early data suggest that these methods are effective and well-tolerated, with an acceptable complication rate. This chapter, an overview of established and experimental ablative methods, as well as clinical results reported thus far.

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References

  1. El-Serag HB, Mason AC. Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med 1999;340:745–750.

    Article  PubMed  CAS  Google Scholar 

  2. El-Serag HB, Mason AC. Risk factors for the rising rates of primary liver cancer in the United States. Arch Intern Med 2000;160:3227–3230.

    Article  PubMed  CAS  Google Scholar 

  3. Taylor-Robinson SD, Foster GR, Arora S, Hargreaves S, Thomas HC. Increase in primary liver cancer in the UK, 1979-94. Lancet 1997;350:1142–1143.

    Article  PubMed  CAS  Google Scholar 

  4. Boring CC, Squires TS, Tong MS. Cancer statistics. CA Cancer J Clin 1994;44:7–26.

    PubMed  CAS  Google Scholar 

  5. National Cancer Institute. Cancer statistics review 1973-1987. NIH publication no. 90-279. Bethesda, MD: National Cancer Institute, 1990.

    Google Scholar 

  6. Scheele J, Stang R, Altendorf-Hofmann A, Paul M. Resection of colorectal liver metastases. World J Surg 1995;19:59–71.

    Article  PubMed  CAS  Google Scholar 

  7. Tranberg KG. Percutaneous ablation of liver tumors. Best Pract Res Clin Gastroenterol 2004;18: 125–145.

    Article  PubMed  Google Scholar 

  8. Farmer DG, Rosove MH, Shaked A, Busuutil RW. Current treatment modalities for hepatocellular carcinoma. Ann of Surg 1994;219:236–247.

    Article  CAS  Google Scholar 

  9. Stone HH, Long WD, Smith RB 3rd, Haynes CD. Physiologic considerations in major hepatic resections. Am J Surg 1969; 117:78–84.

    Article  PubMed  CAS  Google Scholar 

  10. Sugiura NT, K.Ohto, M. Treatment of small hepatocellular carcinoma by percutaneous injection of ethanol into tumor with real-time ultrasound scanning. Acta Hepatol Jpn 1983;24:920.

    Google Scholar 

  11. Livraghi T, Bolondi L, Lazzaroni S, et al. Percutaneous ethanol injection in the treatment of hepatocellular carcinoma in cirrhosis. A study on 207 patients. Cancer 1992;69:925–929.

    Article  PubMed  CAS  Google Scholar 

  12. Giorgio A, Tarantino L, de Stefano G, et al. Ultrasound-guided percutaneous ethanol injection under general anesthesia for the treatment of hepatocellular carcinoma on cirrhosis: long-term results in 268 patients. Eur J Ultrasound 2000;12:145–154.

    Article  PubMed  CAS  Google Scholar 

  13. Bartolozzi C, Lencioni R. Ethanol injection for the treatment of hepatic tumors. Eur Radiol 1996;6: 682–696.

    PubMed  CAS  Google Scholar 

  14. Shiina S, Tagawa K, Unuma T, et al. Percutaneous ethanol injection therapy of hepatocellular carcinoma: analysis of 77 patients. AJR Am J Roentgenol 1990;155:1221–1226.

    PubMed  CAS  Google Scholar 

  15. De Sanctis JT, Goldberg SN, Mueller PR. Percutaneous treatment of hepatic neoplasms: a review of current techniques. Cardiovasc Intervent Radiol 1998;21:273–296.

    Article  PubMed  Google Scholar 

  16. Ebara M, Kita K, Nagato Y, Yoshikawa M, Sugiura N, Ohto M. Percutaneous ethanol injection (PEI) for small hepatocellular carcinoma]. Gan To Kagaku Ryoho 1993;20:884–888.

    PubMed  CAS  Google Scholar 

  17. Sheu JC, Huang A, Chen DS, Sung JL, Yang PM. Small hepatocellular carcinoma: intratumor ethanol treatment using new needle and guidance systems. Radiology 1987;163:43–48.

    PubMed  CAS  Google Scholar 

  18. Livraghi T, Giorgio A, Marin G, et al. Hepatocellular carcinoma and cirrhosis in 746 patients: longterm results of percutaneous ethanol injection. Radiology 1995;197:101–108.

    PubMed  CAS  Google Scholar 

  19. Erce C, Parks RW. Interstitial ablative techniques for hepatic tumors. Br J Surg 2003;90:272–289.

    Article  PubMed  CAS  Google Scholar 

  20. Bartolozzi C, Lencioni R, Ricci P, Paolicchi A, Rossi P, Passariello R. Hepatocellular carcinoma treatment with percutaneous ethanol injection: evaluation with contrast-enhanced color Doppler US. Radiology 1998;209:387–393.

    PubMed  CAS  Google Scholar 

  21. Shiina S, Tagawa K, Unuma T, et al. Percutaneous ethanol injection therapy for hepatocellular carcinoma. A histopathologic study. Cancer 1991;68:1524–1530.

    Article  PubMed  CAS  Google Scholar 

  22. Vilana R, Bruix J, Bru C, Ayuso C, Sole M, Rodes J. Tumor size determines the efficacy of percutaneous ethanol injection for the treatment of small hepatocellular carcinoma. Hepatology 1992;16: 353–357.

    Article  PubMed  CAS  Google Scholar 

  23. Lee MJ, Mueller PR, Dawson SL, et al. Percutaneous ethanol injection for the treatment of hepatic tumors: indications, mechanism of action, technique, and efficacy. AJR Am J Roentgenol 1995;164:215–220.

    PubMed  CAS  Google Scholar 

  24. Elgindy N, Lindholm H, Gunven P. High-dose percutaneous ethanol injection therapy of liver tumors. Patient acceptance and complications. Acta Radiol 2000;41:458–463.

    Article  PubMed  CAS  Google Scholar 

  25. Shiina S, Tagawa K, Niwa Y, et al. Percutaneous ethanol injection therapy for hepatocellular carcinoma: results in 146 patients. AJR Am J Roentgenol 1993;160:1023–1028.

    PubMed  CAS  Google Scholar 

  26. Rustemovic N, Vucelic B, Opacic M, et al. Palliative treatment of hepatocellular carcinoma with percutaneous ethanol injection using tumor’s feeding artery occlusion under the ultrasonic Doppler guidance. Coll Antropol 2004;28:781–791.

    PubMed  Google Scholar 

  27. Lencioni R, Algaier HP, Cioni D, Olschewksi M, Dreibert P, Crocetti L. Small hepatocellular carcinoma in cirrhosis: randomized controlled comparison of radiofrequency thermal ablation vs percutaneous ethanol injection. Radiology 2003;228:235–420.

    Article  PubMed  Google Scholar 

  28. Yammamoto J, Oka M, Shimada K, et al. Treatment strategy for hepatocellular carcinoma: comparison of long-term results after percutaneous ethanol injection therapy and surgicalresection. Hepatology 2001;34:707–713.

    Article  Google Scholar 

  29. Lin SM, Lin DY, Lin CJ. Percutaneous ethanol injection therapy in 47 cirrhotic patients with hepatocellular carcinoma 5 cm or less: a long-term result. Int J Clin Pract 1999;53:257–262.

    PubMed  CAS  Google Scholar 

  30. Livraghi T, Benedini V, Lazzaroni S, Meloni F, Torzilli G, Vettori C. Long term results of single session percutaneous ethanol injection in patients with large hepatocellular carcinoma. Cancer 1998;83:48–57.

    Article  PubMed  CAS  Google Scholar 

  31. Orlando A, Cottone M, Virdone R, et al. Treatment of small hepatocellular carcinoma associated with cirrhosis by percutaneous ethanol injection. A trial with a comparison group. Scand J Gastroenterol 1997;32:598–603.

    Article  PubMed  CAS  Google Scholar 

  32. Lencioni R, Bartolozzi C, Caramella D, et al. Treatment of small hepatocellular carcinoma with percutaneous ethanol injection. Analysis of prognostic factors in 105 Western patients. Cancer 1995;76:1737–1746.

    Article  PubMed  CAS  Google Scholar 

  33. Isobe H, Sakai H, Imari Y, Ikeda M, Shiomichi S, Nawata H. Intratumor ethanol injection therapy for solitary minute hepatocellular carcinoma. A study of 37 patients. J Clin Gastroenterol 1994; 18: 122–126.

    Article  PubMed  CAS  Google Scholar 

  34. Castellano L, Calandra M, Del Vecchio Blanco C, de Sio I. Predictive factors of survival and intrahepatic recurrence of hepatocellular carcinoma in cirrhosis after percutaneous ethanol injection: analysis of 71 patients. J Hepatol 1997;27:862–870.

    Article  PubMed  CAS  Google Scholar 

  35. Castells A, Bruix J, Bru C, et al. Treatment of small hepatocellular carcinoma in cirrhotic patients: a cohort study comparing surgical resection and percutaneous ethanol injection. Hepatology 1993;18:1121–1116.

    PubMed  CAS  Google Scholar 

  36. Omata M, Tateishi R, Yoshida H, Shiina S. Treatment of hepatocellular carcinoma by percutaneous tumor ablation methods; ethanol injection therapy and radiofrequency ablation. Gastrenterology 2004;127:S159–S166.

    Article  Google Scholar 

  37. Mazzanti R, Arena U, Pantaleo P, et al. Survival and prognostic factors in patients with hepatocellular carcinoma treated by percutaneous ethanol injection: a 10-year experience. Can J Gastroenterol 2004;18:611–618.

    PubMed  Google Scholar 

  38. Grieco A, Pompili M, Caminiti G, et al. Prognostic factors for survival in patient with early intermediate hepatocellular carcinoma undergoing non-surgical therapy: comparison of Okuda, CLIP and BCLC staging systems in a single Italian center. Gut 2005;54:328–329.

    Article  Google Scholar 

  39. Livraghi T, Bolondi L, Buscarini L. No treatment, resection and ethanol injection in hepatocellular carcinoma; aretrospective analysis of survival in 391 patients with cirrhosis. Italian Coperative Study Group. J Hepatol 1995;22:522–526.

    Article  PubMed  CAS  Google Scholar 

  40. Arii S, Yamaoka Y, Futagawa S. Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: a retrospective and nationwide survey in Japan. The Liver Study Group of Japan. Hepatology 2000;32:1224–1229.

    CAS  Google Scholar 

  41. Andriulli A, de Sio L, Solmi L, et al. Survival of cirrhotic patients with early hepatocellular carcinoma treated by percutaneous ethanol injection or liver transplantation. Liver Transplant 2004; 10: 1355–1363.

    Article  Google Scholar 

  42. Blum HE. Treatment of hepatocellular carcinoma. Best Pract Res Clin Gastroenterol 2005;19:129–145.

    Article  PubMed  CAS  Google Scholar 

  43. Koda M, Muruwaki Y, Mitsuda A. Combination therapy with transarterial catheter embolisation and percutaneous ethanol injection alone for patients with small hepatocellular carcinoma: a randomized controlled study. Cancer 2001;92:1516–1524.

    Article  PubMed  CAS  Google Scholar 

  44. Seror O, N’Kontchou G, Haddar D, et al. Large infiltrative hepatocellular carcinomas: treatment with percutaneous intraarterial ethanol injection alone or in combination with percutaneous ethanol injection. Radiology 2004;234:299–309.

    Article  PubMed  Google Scholar 

  45. Poggi G, Gatti C, Teragni C, Delmonte A, Bernardo C. Radiofrequency ablation combined with percutaneous ethanol injection in the treatment of hepatocellular carcinoma and portal vein neoplastic thrombosis. Anticancer Res 2004;24:2419–2421.

    PubMed  Google Scholar 

  46. Shankar S, van Sonnenberg E, Morrison PR, Tuncali K, Silverman SG. Combined radiofrequency ablation and alcohol injection for percutaneous hepatic tumor ablation. AJR Am J Roentol 2004;183:1425–1429.

    Google Scholar 

  47. Livraghi T, Goldberg SN, Lazzaroni S, Meloni F, Sublimate L, Gazelle GS. Small hepatocellular carcinoma: treatment with radio-frequency ablation vs ethanol injection. Radiology 1999;210: 655–661.

    PubMed  CAS  Google Scholar 

  48. Amin Z, Bown SG, Lees WR. Local treatment of colorectal liver metastases: a comparison of interstitial laser photocoagulation (ILP) and percutaneous alcohol injection (PAI). Clin Radiol 1993;48:166–171.

    Article  PubMed  CAS  Google Scholar 

  49. Livraghi T, Vettori C, Lazzaroni S. Liver metastases: results of percutaneous ethanol injection in 14 patients. Radiology 1991;179:709–712.

    PubMed  CAS  Google Scholar 

  50. Giovannini M, Seitz JF. Ultrasound-guided percutaneous alcohol injection of small liver metastases. Results in 40 patients. Cancer 1994;73:294–297.

    Article  PubMed  CAS  Google Scholar 

  51. Mazziotti A, Grazi GL, Gardini A, et al. An appraisal of percutaneous treatment of liver metastases. Liver Transplant Surg 1998;4:271–275.

    Article  CAS  Google Scholar 

  52. Redvanly RD, Chezmar JL, Strauss RM, Galloway JR, Boyer TD, Bernardino ME. Malignant hepatic tumors: safety of high-dose percutaneous ethanol ablation therapy. Radiology 1993;188:283–285.

    PubMed  CAS  Google Scholar 

  53. Lencioni R, Caramella D, Bartolozzi C. Hepatocellular carcinoma: use of color Doppler US to evaluate response to treatment with percutaneous ethanol injection. Radiology 1995;194:113–118.

    PubMed  CAS  Google Scholar 

  54. Lencioni R, Cioni D, Uliana M, Bartolozzi C. Fatal thrombosis of the portal vein following singlesession percutaneous ethanol injection therapy of hepatocellular carcinoma. Abdom Imaging 1998;23:608–610.

    Article  PubMed  CAS  Google Scholar 

  55. Taavitsainen M, Vehmas T, Kauppila R. Fatal liver necrosis following percutaneous ethanol injection for hepatocellular carcinoma. Abdom Imaging 1993;18:357–359.

    Article  PubMed  CAS  Google Scholar 

  56. Koda M, Okamoto K, Miyoshi Y, Kawasaki H. Hepatic vascular and bile duct injury after ethanol injection therapy for hepatocellular carcinoma. Gastrointest Radiol 1992;17:167–169.

    Article  PubMed  CAS  Google Scholar 

  57. Ishii H, Okada S, Okusaka T, et al. Needle tract implantation of hepatocellular carcinoma after percutaneous ethanol injection. Cancer 1998;82:1638–1642.

    Article  PubMed  CAS  Google Scholar 

  58. Huo C, Chen SC, Chang WY, Chen CH. Comparison of necrotic characteristics and benefits between 50% acetic acid and pure ethanol in local hepatic injection: a study in rats. Kaohsiung J Med Sci 1999;15:414–418.

    Google Scholar 

  59. Arrive L, Rosmorduc O, Dahan H, et al. Percutaneous acetic acid injection for hepatocellular carcinoma: using CT fluoroscopy to evaluate distribution of acetic acid mixed with an iodinated contrast agent. AJR Am J Roentgenol 2003;180:159–162.

    PubMed  Google Scholar 

  60. Huo TI, Huang YH, Wu JC, Lee PC, Chang FY, Lee SD. Persistent retention of acetic acid is associated with complete tumor necrosis in patients with hepatocellular carcinoma undergoing percutaneous acetic acid injection. Scand J Gastroenterol 2004;39:168–173.

    Article  PubMed  CAS  Google Scholar 

  61. Ohnishi K. Comparison of percutaneous acetic acid injection and percutaneous ethanol injection for small hepatocellular carcinoma. Hepatogastroenterology 1998;45(suppl 3):1254–1258.

    PubMed  CAS  Google Scholar 

  62. Liang HL, Yang CF, Pan HB, et al. Small hepatocellular carcinoma: safety and efficacy of single highdose percutaneous acetic acid injection for treatment. Radiology 2000;214:769–774.

    PubMed  CAS  Google Scholar 

  63. Huo TI, Huang YH, Wu JC, Lee PC, Chang FY, Lee SD. Comparison of percutaneous acetic acid injection and percutaneous ethanol injection for hepatocellular carcinoma in cirrhotic patients; a prospective study. Scand J Gastroenterol 2003;38:770–778.

    Article  PubMed  CAS  Google Scholar 

  64. Huo T, Huang YH, Wu JC, et al. Comparison of transarterial catheter embolisation and percutaneous acetic acid injection as the primary loco-regional therapy for unresectable hepatocellular carcinoma, a prospective survey. Aliment Pharmacol Ther 2004; 19:1301–1308.

    Article  PubMed  CAS  Google Scholar 

  65. Chen HB, Huang YH, Dai DL, et al. Therapeutic effect of transcatheter arterial chemoembolisation and percutaneous injection of acetic acids on primary liver cancer. Hepatobiliary Pancreatic Dis Int 2004;3:55–57.

    CAS  Google Scholar 

  66. Huo TI, Huang YH, Wu JC, et al. Sequential transarterial chemoembolisation and percutaneous acetic acid injection therapy vs repeated percutaneous acetic acid injection for unresectable hepatocellular carcinoma; a prospective study. Ann Oncol 2003;14:1648–1653.

    Article  PubMed  Google Scholar 

  67. Koda M, Tanaka H, Murawaki Y, et al. Liver perforation: a serious complication of percutaneous acetic acid injection for hepatocellular carcinoma. Hepatogastroenterology 2000;47:1110–1112.

    PubMed  CAS  Google Scholar 

  68. Van Hoof M, Joris JP, Horsmans Y, Geubel A. Acute renal failure requiring hemodialysis after high dose percutaneous acetic acid injection for hepatocellular carcinoma. Acta Gastroenterol Belg 1999;62:49–51.

    Google Scholar 

  69. Tamai T, Seki T, Imamura M, et al. Percutaneous injection of a low-concentration alkaline solution targeting hepatocellular carcinoma. Oncol Rep 2000;7:719–723.

    PubMed  CAS  Google Scholar 

  70. Arakii Y, Hukano M, Urabe M, et al. Hepatocellular carcinoma treated by percutaneous hot saline injection. Oncol Rep 2004;12:569–571.

    Google Scholar 

  71. Okuda S, Kuroda K, Oshio K, et al. MR-based temperature monitoring for hot saline injection therapy. J Magn Reson Imaging 2000; 12:330–338.

    Article  PubMed  CAS  Google Scholar 

  72. Lounsberry WG, V. Linke, C. The early histological changes following electrocoagulation. Gastrointest Endosc 1995;41:68–70.

    Article  Google Scholar 

  73. Goldberg SN, Gazelle GS, Dawson SL, Rittman WJ, Mueller PR, Rosenthal DI. Tissue ablation with radiofrequency: effect of probe size, gage, duration, and temperature on lesion volume. Acad Radiol 1995;2:399–404.

    Article  PubMed  CAS  Google Scholar 

  74. McGahan JP, Browning PD, Brock JM, Tesluk H. Hepatic ablation using radiofrequency electrocautery. Invest Radiol 1990;25:267–270.

    Article  PubMed  CAS  Google Scholar 

  75. Goldberg SN, Gazelle GS, Halpern EF, Rittman WJ, Mueller PR, Rosenthal DI. Radiofrequency tissue ablation: importance of local temperature along the electrode tip exposure in determining lesion shape and size. Acad Radiol 1996;3:212–218.

    Article  PubMed  CAS  Google Scholar 

  76. Solbiati L, Ierace T, Goldberg SN, et al. Percutaneous US-guided radio-frequency tissue ablation of liver metastases: treatment and follow-up in 16 patients. Radiology 1997;202:195–203.

    PubMed  CAS  Google Scholar 

  77. Patterson EJ, Scudamore CH, Owen DA, Nagy AG, Buczkowski AK. Radiofrequency ablation of porcine liver in vivo: effects of blood flow and treatment time on lesion size. Ann Surg 1998;227: 559–565.

    Article  PubMed  CAS  Google Scholar 

  78. Goldberg SN, Gazelle GS, Dawson SL, Rittman WJ, Mueller PR, Rosenthal DI. Tissue ablation with radiofrequency using multiprobe arrays. Acad Radiol 1995;2:670–674.

    Article  PubMed  CAS  Google Scholar 

  79. Livraghi T, Goldberg SN, Monti F, et al. Saline-enhanced radio-frequency tissue ablation in the treatment of liver metastases. Radiology 1997;202:205–210.

    PubMed  CAS  Google Scholar 

  80. Curley SA, Izzo F, Ellis LM, Nicolas Vauthey J, Vallone P. Radiofrequency ablation of hepatocellular cancer in 110 patients with cirrhosis. Ann Surg 2000;232:381–391.

    Article  PubMed  CAS  Google Scholar 

  81. Miao Y, Ni Y, Yu J, Zhang H, Baert A, Marchai G. An ex vivo study on radiofrequency tissue ablation: increased lesion size by using an “expandable-wet” electrode. Eur Radiol 2001;11:1841–1847.

    Article  PubMed  CAS  Google Scholar 

  82. Scott DJ, Fleming JB, Watumull LM, Lindberg G, Tesfay ST, Jones DB. The effect of hepatic inflow occlusion on laparoscopic radiofrequency ablation using simulated tumors. Surg Endosc 2002;23:23.

    Google Scholar 

  83. Yamasaki T, Kurokawa F, Shirahashi H, Kusano N, Hironaka K, Okita K. Percutaneous radiofrequency ablation therapy for patients with hepatocellular carcinoma during occlusion of hepatic blood flow. Comparison with standard percutaneous radiofrequency ablation therapy. Cancer 2002;95: 2353–2360.

    Article  PubMed  Google Scholar 

  84. Buscarini L, Rossi S, Fornari F, Di Stasi M, Buscarini E. Laparoscopic ablation of liver adenoma by radiofrequency electrocautery. Gastrointest Endosc 1995;41:68–70.

    Article  PubMed  CAS  Google Scholar 

  85. Beber E, Foroutani A, Garland A. Use of CT Hounsfield unit density to identify ablated tumor after laparoscopic radiofrequency ablation of liver tumors. Br J Surg 2000; 14:799–804.

    Google Scholar 

  86. Anderson CD, Li WC, Beckham J, et al. Fluorescence spectroscopy accurately detects irreversible cell damage during radiofrequency ablation. Surgery 2004;136:524–531.

    Article  PubMed  Google Scholar 

  87. Zhou W, Strobel D, Haensler J, Bernatik T. Hepatic transit time: indicator of the therapeutic response to radiofrequency ablation of liver tumors. Br J Radiol 2005;78:433–436.

    Article  PubMed  CAS  Google Scholar 

  88. Blokhuis TJ, van der Schaaf MC, van den Tol MP, Comans EF, Manoliu RA, van der Sijp JR. Results of radiofrequency ablation of primary and secondary liver tumors: long term follow-up with computed tomography and positron emission tomography-18F-deoxofluoroglucose scanning. Scand J Gastroenterol 2004;241:93–97.

    Article  Google Scholar 

  89. Rossi S, Stasi M, Buscarini E. Percutaneous radiofrequency interstitial thermal ablation in the treatment of small hepatocellular carcinoma. Cancer J Sci Am 1995;1:73–77.

    PubMed  CAS  Google Scholar 

  90. Rossi S, Di Stasi M, Buscarini E. Interstitial thermal ablation in the treatment of hepatic cancer. AJR Am J Roentgenol 1996;167:759–768.

    PubMed  CAS  Google Scholar 

  91. Solbiati L, Goldberg SN, Ierace T. Hepatic metastases: percutaneous radiofrequency ablation with cooled-tip electrodes. Radiology 1997;205:367–373.

    PubMed  CAS  Google Scholar 

  92. Lencioni R, Goletti O, Armillota N. Radiofrequency thermal ablation of liver metastases with a cooled-tip electrode needle: results of a pilot clinical trial. Eur Radiol 1998;8:1205–1211.

    Article  PubMed  CAS  Google Scholar 

  93. Rossi S, Buscarini E, Garbagnati F. Percutaneous treatment of small heaptic tumors by an expandable RF electrode needle. AJR Am J Roentgenol 1998; 170:1015–1022.

    PubMed  CAS  Google Scholar 

  94. Allgaier HP, Deibert P, Zuber I. Percutaneous radiofrequency interstitial thermal ablation of small hepatocellular carcinoma. Lancet 1999;353:1676–1677.

    Article  PubMed  CAS  Google Scholar 

  95. Buscarini L, Buscarini E, Di Stasi M. Percutaneous radiofrequency ablation combined with transcatheter arterial embolisation in the treatment of large hepatocellular carcinoma. Ultraschall Med 1999;20:47–53.

    Article  PubMed  CAS  Google Scholar 

  96. Curley SA, Izzo F, Delrio P. Radiofrequency ablation of unresectable primary and metastatic hepatic malignancies: results in 123 patients. Am Surg 1999;230:1–8.

    CAS  Google Scholar 

  97. Cushieri A, Bracken J, Bony L. Initial experience with laparoscopic ultrasound-guided radiofrequency thermal ablation of hepatic tumors. Endoscopy 1999;31:318–321.

    Article  Google Scholar 

  98. Francica G, Marone G. Ultrasound-guided percutaneous treatment of hepatocellular carcinoma by radiofrequency hyperthermia with a “cooled-tip needle.” A preliminary clinical experience. Eur J Ultrasound 1999;210:145–153.

    Article  Google Scholar 

  99. Jiao LR, Hansen PD, Havlik R. Clinical short-term results of radiofrequency ablation in primary and secondary liver tumors. Am J Surg 1999; 177:303–306.

    Article  PubMed  CAS  Google Scholar 

  100. Livraghi T, Goldberg SN, Lazzaroni S. Small hepatocellular carcinoma: treatment with radiofrequency ablation vs ethanol injection. Radiology 1999;210:655–661.

    PubMed  CAS  Google Scholar 

  101. Pearson AS, Izzo F, Fleming RY. Intraoperative radiofrequency ablation or cryoablation for hepatic malignancies. Am J Surg 1999;178:592–599.

    Article  PubMed  CAS  Google Scholar 

  102. Scudamore CH, Lee SI, Patterson EJ. Radiofrequency ablation followed by resection of malignant liver tumors. Am J Surg 1999; 177:411–417.

    Article  PubMed  CAS  Google Scholar 

  103. Bilchik AJ, Wood TF, Allegra D. Cryosurgical ablation and radiofrequency ablation for unresectable hepatic malignant neoplasms. A proposed algorithm. Arch Surg 2000;135:657–664.

    Article  PubMed  CAS  Google Scholar 

  104. Burley SA, Izzo F, Ellis LM. Radiofrequency ablation of hepatocellular cancer in 110 patients with cirrhosis. Ann of Surg 2000;232:381–391.

    Article  Google Scholar 

  105. De Baere T, Elias D, Dromain C. Radiofrequency ablation of 100 hepatic metastases with a mean follow-up of more than 1 year. AJR Am J Roentgenol 2000;175:1619–1625.

    PubMed  Google Scholar 

  106. Goletti O, Lencioni R, Armillota N. Laparoscopic radiofrequency thermal ablation of hepatocarcinoma: preliminary experience. Surg Laparosc Endosc Percutan Tech 2000; 10:284–290.

    Article  PubMed  CAS  Google Scholar 

  107. Holtkamp W, Muller W. Ultrasonically controlled percutaneous high frequency thermotherapy of liver tumors with perfused needle electrodes. Z Gastroenterol 2000;38:221–227.

    Article  PubMed  CAS  Google Scholar 

  108. Huppert PE, Trubenbach J, Schick F. MRI-guided percutaneous radiofrequency ablation of hepatic neoplasms—first technical and clinical experience. Rofo Fortschr Geb Rontgenstr Neuen Bildgbeb Verfahr 2000; 172:692–700.

    Article  CAS  Google Scholar 

  109. Livraghi T, Goldberg SN, Lazzaroni S. Hepatocellular carcinoma: radiofrequency ablation of medium and large lesions. Radiology 2000;214:761–768.

    PubMed  CAS  Google Scholar 

  110. Siperstein A, Garland A, Engle K. Laparoscopic radiofrequency ablation of primary and metastatic liver tumors. Technical considerations. Surg Endosc 2000; 14:400–405.

    Article  PubMed  CAS  Google Scholar 

  111. Wood TF, Rose DM, Chung M. Radiofrequency ablation of 231 unresectable hepatic tumors: indications, limitations and complications. Ann Surg Oncol 2000;7:593–600.

    PubMed  CAS  Google Scholar 

  112. Bewies B J, Machi J, Limm WLM. Safety and efficacy of radiofrequency thermal ablation in advanced liver tumors. Arch Surg 2001;136:864–869.

    Article  Google Scholar 

  113. Chung M, Wood TF, Tsioulias GJ. Laparoscopic radiofrequency ablation of unresectable hepatic malignancies: a phase II trial. Surg Endosc 2001; 15:1020–1026.

    Article  PubMed  CAS  Google Scholar 

  114. De Sio I, Castellano L, Girolamo V, al. Tumor dissemination after radiofrequency ablation of hepatocellular carcinoma. Hepatology 2001;34:609–610.

    Article  PubMed  Google Scholar 

  115. Ikeda M, Okada S, Ueno H. Radiofrequency ablation and percutaneous ethanol injection in patients with small hepatocellular carcinoma; a comparative study. Jpn J Clin Oncol 2001;31:322–326.

    Article  PubMed  CAS  Google Scholar 

  116. Lin HK, Choi D, Lee WJ. Hepatocellular carcinoma treated with percutaneous radiofrequency ablation: evaluation with follow-up multiphase helical CT. Radiology 2001;221:447–454.

    Article  Google Scholar 

  117. Llovet JM, Vilana R, Bru C. Increased risk of tumor seeding after percutaneous radiofrequency ablation for single hepatocellular carcinoma. Hepatology 2001;33:1124–1129.

    Article  PubMed  CAS  Google Scholar 

  118. Machi J, Uchida S, Sumida K. Ultrasound-guided radiofrequency thermal ablation of liver tumors: percutaneous, laparoscopic and open surgical approaches. J Gastrointest Surg 2001;5:477–489.

    Article  PubMed  CAS  Google Scholar 

  119. Podnos YD, Henry G, Ortiz JA. Laparoscopic ultrasound with radiofrequency ablation in cirrhotic patients with hepatocellular carcinoma; technique and technical considerations. Am Surg 2001;67: 1181–1184.

    PubMed  CAS  Google Scholar 

  120. Berber E, Flesher N, Siperstein AE. Laparoscopic radiofrequency ablation of neuroendocrine liver metastases. World J Surg 2002;26:985–990.

    Article  PubMed  Google Scholar 

  121. Chan RP, Asch M, Kachura J. Radiofrequency ablation of malignant hepatic neoplasms. Can Assoc Radiol 2002;53:272–278.

    Google Scholar 

  122. Elias D, De Baere T, Smayra T. Percutaneous radiofrequency thermoablation as an alternative to surgery for the treatment of liver tumor recurrence after hepatectomy. Br J Surg 2002;89:752–756.

    Article  PubMed  CAS  Google Scholar 

  123. Hosida Y, Shiratori Y, Koike T. Hepatic volumetry to predict adverse events in percutaneous ablation of hepatocellular carcinoma. Hepatogastroenterology 2002;49:451–455.

    Google Scholar 

  124. Iannitti DA, Dupuy DE, Mayo-Smith WW, Murphy B. Hepatic radiofrequency ablation. Arch Surg 2002;137:422–427.

    Article  PubMed  Google Scholar 

  125. Kosari K, Gomes M, Hunter D, al. e. Local intrahepatic and systemic recurrence patterns after radiofrequency ablation of hepatic malignancies. J Gastrointest Surg 2002;6:255–263.

    Article  PubMed  Google Scholar 

  126. Kurshinoff BW, Ota DM. Radiofrequency ablation of liver tumors; influence of technique and tumors size. Surgery 2002;132:605–612.

    Article  Google Scholar 

  127. Morimoto M, Sufimori K, Shirato K. Treatment of hepatocellular carcinoma with radiofrequency ablation: radiologic-histologic correlation during follow-up periods. Hepatology 2002;35:1467–1475.

    Article  PubMed  Google Scholar 

  128. Miyamoto N, Tsuji K, Sakurai Y, et al. Percutaneous radiofrequency ablation for unresectable large hepatic tumors during hepatic blood flow occlusion in four patients. Clin Radiol 2004;59:812–818.

    Article  PubMed  CAS  Google Scholar 

  129. Gillams AR, Cassoni A, Conway G, Lees W. Radiofrequency ablation of neuroendocrine liver metastases: the Middlesex experience. Abdom Imaging 2005;30:435–441.

    Article  PubMed  CAS  Google Scholar 

  130. Tateishi R, Shiina S, Teratani T, et al. Percutaneous radiofrequency ablation for hepatocellular carcinoma. An analysis of 1000 cases. Cancer 2005;103:1201–1209.

    Article  PubMed  Google Scholar 

  131. Shibata T, Limuro Y, Yamamoto Y. Small hepatocellular carcinoma: comparison of radio-frequency ablation and percutaneous microwave coagulation therapy. Vasc Intervent Radiol 2001;2001:331–337.

    Google Scholar 

  132. Shetty SK, Rosen MP, Raptopoulos V, Goldberg SN. Cost-effectiveness of percutaneous radiofrequency ablation for malignant hepatic neoplasms. J Vasc Interv Radiol 2001;12:823–833.

    Article  PubMed  CAS  Google Scholar 

  133. Gazelle GS, McMahon PM, Beinfeld MT, Halpern EF, Weinstein MC. Metastatic colorectal carcinoma: cost-effectiveness of percutaneous radiofrequency ablation vs that of hepatic resection. Radiology 2004;233:729–739.

    Article  PubMed  Google Scholar 

  134. Yu HC, Cheng JS, Lai KH, et al. Factors for early tumor recurrence of single small hepatocellular carcinoma after percutaneous radiofrequency ablation therapy. 2005;14:1439–1444.

    Google Scholar 

  135. Berber E, Pelly R, Siperstein A. Predictors of survival after radiofrequency thermal ablation of colorectal cancer metastases to the liver; a prospective study. J Clin Oncol 2005;23:1358–1364.

    Article  PubMed  Google Scholar 

  136. Choy PY, Koea J, McCall J, Holden A, Osbourne M. The role of radiofrequency ablation in the treatment of primary and metastatic tumors of the liver: initial lessons learned. N Z Med J 2002;115:U128.

    PubMed  Google Scholar 

  137. Crucitti A, Danza FM, Pirulli PG, et al. Radiofrequency thermal ablation (RFA) of liver tumors: open surgical or percutaneous approaches. J Chemother 2004;16:82–85.

    PubMed  Google Scholar 

  138. de Baere T, Bessoud B, Dromain C, et al. Percutaneous radiofrequency ablation of hepatic tumors during temporary venous occlusion. AJR Am J Roentgenol 2002;178:53–59.

    PubMed  Google Scholar 

  139. Poggi G, Gatti C, Cupella F, Fiori M, Avanza F, Baldi M. Percutaneous US-guided radiofrequency ablation of hepatocellular carcinomas: results in 15 patients. Anticancer Res 2001;21:739–742.

    PubMed  CAS  Google Scholar 

  140. Nicoli N, Casaril A, Marchiori L, et al. Intraoperative and percutaneous radiofrequency thermal ablation in the treatment of hepatocellular carcinoma. Chir Ital 2000;52:29–40.

    PubMed  CAS  Google Scholar 

  141. Frieser M, Haensler J, Schaber S, et al. Radiofrequency ablation of liver tumors: how to enlarge the necrotic zones. Eur J Surg Res 2004;36:357–361.

    Article  CAS  Google Scholar 

  142. Mahnken AH, Tacke J, Bucker A, Gunther RW. [Percutaneous radiofrequency ablation of liver malignancies: first experience with a 200-W radiofrequency generator]. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 2002;174:216–223.

    Article  PubMed  CAS  Google Scholar 

  143. Yang R, Reilly CR, Rescorla FJ, et al. High-intensity focused ultrasound in the treatment of experimental liver cancer. Arch Surg 1991;126:1002–1009; discussion 9-10.

    PubMed  CAS  Google Scholar 

  144. Wu F, Chen WZ, Bai J, et al. Tumor vessel destruction resulting from high-intensity focused ultrasound in patients with solid malignancies. Ultrasound Med Biol 2002;28:535–542.

    Article  PubMed  Google Scholar 

  145. Poliachik SL, Chandler WL, Mourad PD, Olios RJ, Crum LA. Activation, aggregation and adhesion of platelets exposed to high-intensity focused ultrasound. Ultrasound Med Biol 2001;27:1567–1576.

    Article  PubMed  CAS  Google Scholar 

  146. Wu F, Chen WZ, Bai J, et al. Pathological changes in human malignant carcinoma treated with highintensity focused ultrasound. Ultrasound Med Biol 2001;27:1099–1106.

    Article  PubMed  CAS  Google Scholar 

  147. Vaezy S, Martin R, Crum L. High intensity focused ultrasound: a method of hemostasis. Echocardiography 2001;18:309–315.

    Article  PubMed  CAS  Google Scholar 

  148. Yang R, Sanghvi NT, Rescorla FJ, et al. Extracorporeal liver ablation using sonography-guided highintensity focused ultrasound. Invest Radiol 1992;27:796–803.

    Article  PubMed  CAS  Google Scholar 

  149. Chapleton JP, Sibille A., Abou-el-Fadil F., Theillere Y., Cthignol D. Extracorporeal selective focused destruction of hepatic tumors by high intensity ultrasound in rabbits bearing VX-2-carcinoma. Min Invas Ther 1992;10:125–131.

    Google Scholar 

  150. Linke CA, Carstensen EL, Frizzell LA, Elbadawi A, Fridd CW. Localized tissue destruction by highintensity focused ultrasound. Arch Surg 1973;107:887–891.

    PubMed  CAS  Google Scholar 

  151. Pernot M, Tanter M, Fink M. 3-D real-time motion correction in high-intensity focused ultrasound therapy. Ultrasound Med Biol 2004;9:1239–1249.

    Article  Google Scholar 

  152. Cheng SQ, Zhou XD, Tang ZY, Yu Y, Bao SS, Qian DC. Iodized oil enhances the thermal effect of high-intensity focussed ultrasound. J Res Clin Oncol 1997;123:639–644.

    Article  CAS  Google Scholar 

  153. Satsaki K, Azuma T, Kawabata K, Shimoda S, Koku E, Umemura S. Effect of split-focus approach on producing larger coagulation in swine liver. Ultrasound Med Biol 2003;29:591–599.

    Article  Google Scholar 

  154. Vallancien G, Harouni M, Veillon B, Mombet A, Brisset J, Bougaran J. Focused extracorperal pyotherapy. J Endourol 1992;6:173–181.

    Google Scholar 

  155. Wu F, Wang ZB, Chen WZ, et al. Extracorporeal high intensity focused ultrasound ablation in the treatment of patients with large hepatocellular carcinoma. Ann Surg Oncol 2004;11:1061–1069.

    Article  PubMed  Google Scholar 

  156. Li CX, Xu JL, Jiang ZY, et al. Analysis of clinical effect of high-intenstiy focused ultrasound in liver cancer. World J Gastroenterol 2004;10:2201–2204.

    PubMed  Google Scholar 

  157. Chen W, Wang Z, Wu F, et al. [High intensity focused ultrasound alone for malignant solid tumors]. Zhonghua Zhong Liu Za Zhi 2002;24:278–281.

    PubMed  Google Scholar 

  158. Jin CB, Wu F, Wang ZB, Chen WZ, Zhu H. High intensity focused ultrasound therapy combined with transcatheter arterial chemoembolisation for advanced hepatocellualar carcinoma. Zhonghua Zhong Liu Za Zhi 2003;25:401–403.

    PubMed  Google Scholar 

  159. Thomsen S. Pathologic analysis of photothermal and photomechanical effects of laser-tissue interactions. Photochem Photobiol 1991;53:825–835.

    PubMed  CAS  Google Scholar 

  160. Hunter JG, Dixon JA. Lasers in cardiovascular surgery—current status. West J Med 1985;142: 506–510.

    PubMed  CAS  Google Scholar 

  161. Welch AJ, Motamedi M, Rastegar S, LeCarpentier GL, Jansen D. Laser thermal ablation. Photochem Photobiol 1991;53:815–823.

    PubMed  CAS  Google Scholar 

  162. Murer L, Marijnessen J, Star W. Improvements in the design of linear photodynamic therapy. Phys Med Biol 1997;42:1461–1464.

    Article  Google Scholar 

  163. N0lsoe CP, Torp-Pedersen S, Burcharth F, et al. Interstitial hyperthermia of colorectal liver metastases with a US-guided Nd-YAG laser with a diffuser tip: a pilot clinical study. Radiology 1993;187: 333–337.

    Google Scholar 

  164. Svaasand LO, Boerslid T, Oeveraasen M. Thermal and optical properties of living tissue: application to laser-induced hyperthermia. Lasers Surg Med 1985;5:589–602.

    Article  PubMed  CAS  Google Scholar 

  165. Sturesson C. Interstitial laser-induced thermotherapy: influence of carbonization on lesion size. Lasers Surg Med 1998;22:51–57.

    Article  PubMed  CAS  Google Scholar 

  166. Wyman DR. Selecting source locations in multifiber interstitial laser photocoagulation. Lasers Surg Med 1993;13:656–663.

    Article  PubMed  CAS  Google Scholar 

  167. Heiterkamp J, van Hillegersberg R, Sinofsky E, Ijzermans J. Interstitial Nd: YAG laser coagulation using simultaneous multiple fiber application with an optical beam splitter: importance of mutual fiber distance.

    Google Scholar 

  168. Heisterkamp J, van Hillegersberg R, de Man RA, et al. [Treatment of non-resectable liver tumors with percutaneous interstitial laser coagulation while interrupting blood circulation to the liver]. Ned Tijdschr Geneeskd 2000;144:1542–1548.

    PubMed  CAS  Google Scholar 

  169. Heisterkamp J, van Hillegersberg R, Mulder PG, Sinofsky EL, JNIJ. Importance of eliminating portal flow to produce large intrahepatic lesions with interstitial laser coagulation. Br J Surg 1997;84: 1245–1248.

    Article  PubMed  CAS  Google Scholar 

  170. Heisterkamp J, van Hillegersberg R, Sinofsky E, JN IJ. Heat-resistant cylindrical diffuser for interstitial laser coagulation: comparison with the bare-tip fiber in a porcine liver model. Lasers Surg Med 1997;20:304–309.

    Article  PubMed  CAS  Google Scholar 

  171. Heisterkamp J, van Hillegersberg R, Zondervan PE, JN IJ. Metabolic activity and DNA integrity in human hepatic metastases after interstitial laser coagulation (ILC). Lasers Surg Med 2001;28:80–86.

    Article  PubMed  CAS  Google Scholar 

  172. Germer CT, Isbert C, Albrecht D. Laser-induced thermotherapy combined with heaptic arterial embolisation in the treatment of liver tumors in a rat tumor model. Ann of Surg 1999;230:55–62.

    Article  CAS  Google Scholar 

  173. Moller PH, Lindberg L, Henriksson PH, Persson BR, Tranberg KG. Temperature control and light penetration in a feedback interstitial laser thermotherapy system. Int J Hypertherm 1996;12:49–63.

    CAS  Google Scholar 

  174. Hashimoto D, Takami M, Idezuki Y. In depth radiation therapy by YAG laser for malignant tumors of the liver under ultrasound imaging. Gastrenterology 1985;88:1633.

    Google Scholar 

  175. Huang G, Wang T, Sheu J. Low power laser thermia for the treatment of small hepatocellular carcinoma. Eur J Cancer 1991;27:1622–1627.

    Article  PubMed  CAS  Google Scholar 

  176. Steger AC, Lees WR, Walmsley K, Bown SG. Interstitial laser hyperthermia: a new approach to local destruction of tumors. BMJ 1989;299:362–365.

    PubMed  CAS  Google Scholar 

  177. Vogl TJ, Mack MG, Straub R, Roggan A, Felix R. Magnetic resonance imaging-guided abdominal interventional radiology: laser-induced thermotherapy of liver metastases. Endoscopy 1997;29: 577–583.

    PubMed  CAS  Google Scholar 

  178. Vogl TJ, Muller PK, Hammerstingl R, et al. Malignant liver tumors treated with MR imaging-guided laser-induced thermotherapy: technique and prospective results. Radiology 1995;196:257–265.

    PubMed  CAS  Google Scholar 

  179. Vogl TJ, Straub R, Eichler KC. Malignant liver tumors treated with MR imaging-guided laser-induced thermotherapy: experience with complications in 899 patients. Radiology 2002;225:367–377.

    Article  PubMed  Google Scholar 

  180. Vogl TJ, Eichler KC, Straub R. Laser-induced thermotherapy of malignant liver tumors: general principles, equipment, procedures, side effects, complications and results. Eur J Ultrasound 2001;13:117–127.

    Article  PubMed  CAS  Google Scholar 

  181. Pacella CM, Bizzarri G, Magnolfi F, et al. Laser thermal ablation in the treatment of small hepatocellular carcinoma: results in 74 patients. Radiology 2001;221:712–720.

    Article  PubMed  CAS  Google Scholar 

  182. Gillams AR, Lees WR. Survival after percutaneous, image-guided, thermal ablation of hepatic metastases from colorectal cancer. Dis Colon Rectum 2000;43:656–661.

    Article  PubMed  CAS  Google Scholar 

  183. Giorgio A, Tarantino L, de Stefano G, et al. Interstitial laser photocoagulation under ultrasound guidance of liver tumors: results in 104 treated patients. Eur J Ultrasound 2000;11:181–188.

    Article  PubMed  CAS  Google Scholar 

  184. Caspani B, Cecconi P, Bottelli R, Delia Vigna P, Ideo G, Gozzi G. [The interstitial photocoagulation with laser light of liver tumors]. Radiol Med (Torino) 1997;94:346–354.

    CAS  Google Scholar 

  185. Gillams AR, Brookes J, Hare C. Follow up of patients with metastatic liver lesions treated with interstitial laser therapy. Br J Cancer 1997;196:31.

    Google Scholar 

  186. Tranberg KG, Moller PH, Hannesson P, Stenram U. Interstitial laser treatment of malignant tumors: initial experience. Eur J Surg Oncol 1996;22:47–54.

    Article  PubMed  CAS  Google Scholar 

  187. Pacella CM, Bizzarri G, Ferrari FS, et al. [Interstitial photocoagulation with laser in the treatment of liver metastasis]. Radiol Med (Torino) 1996;92:438–447.

    CAS  Google Scholar 

  188. Prudhomme M, Rouy S, Tang J, Landgrebe J, Delacretaz G, Godlewski G. Biliary structures lead to tumor recurrences after laser-induced interstitial thermotherapy. Lasers Surg Med 1999;24:269–275.

    Article  PubMed  CAS  Google Scholar 

  189. Vogl TJ, Muller PK, Straub R, Roggan A, Felix R. Percutaneous MRI-guided laser-induced thermotherapy for hepatic metastases for colorectal cancer. Lancet 1997;350:29.

    Article  Google Scholar 

  190. Malone DE, Lesiuk L, Brady AP, Wyman DR, Wilson BC. Hepatic interstitial laser photocoagulation: demonstration and possible clinical importance of intravascular gas. Radiology 1994;193:233–237.

    PubMed  CAS  Google Scholar 

  191. Tabuse K. A new operative procedure of hepatic surgery using a microwave tissue coagulator. Nippon GekaHokan 1979;48:160–172.

    CAS  Google Scholar 

  192. Tabuse K, Katsumi M. Application of a microwave tissue coagulator to hepatic surgery the hemostatic effects on spontaneous rupture of hepatoma and tumor necrosis. Nippon Geka Hokan 1981;50: 571–579.

    PubMed  CAS  Google Scholar 

  193. Watanabe Y, Sato M, Abe Y, et al. Laparoscopic microwave coagulo-necrotic therapy for hepatocellular carcinoma: a feasible study of an alternative option for poor-risk patients. J Laparoendosc Surg 1995;5:169–175.

    PubMed  CAS  Google Scholar 

  194. Seki T, Wakabayashi M, Nakagawa T, et al. Ultrasonically guided percutaneous microwave coagulation therapy for small hepatocellular carcinoma. Cancer 1994;74:817–825.

    Article  PubMed  CAS  Google Scholar 

  195. Shimada S, Hirota M, Beppu T, et al. Complications and management of microwave coagulation therapy for primary and metastatic liver tumors. Surg Today 1998;28:1130–1137.

    Article  PubMed  CAS  Google Scholar 

  196. Murakami R, Yoshimatsu S, Yamashita Y, Matsukawa T, Takahashi M, Sagara K. Treatment of hepatocellular carcinoma: value of percutaneous microwave coagulation. AJR Am J Roentgenol 1995;164:1159–1164.

    PubMed  CAS  Google Scholar 

  197. Sato M, Watanabe Y, Kashu Y, Nakata T, Hamada Y, Kawachi K. Sequential percutaneous microwave coagulation therapy for liver tumor. Am J Surg 1998;175:322–324.

    Article  PubMed  CAS  Google Scholar 

  198. Strickland AD, Clegg PJ, Cronin NJ, et al. Experimental study of large-volume microwave ablation in the liver. Br J Surg 2002;89:1003–1007.

    Article  PubMed  CAS  Google Scholar 

  199. Takamura M, Murakami T, Shibata T, et al. Microwave coagulation therapy with interruption of hepatic blood in-or outflow: an experimental study. J Vasc Interv Radiol 2001;12:619–622.

    Article  PubMed  CAS  Google Scholar 

  200. Ishida T, Murakami T, Shibata T, et al. Percutaneous microwave tumor coagulation for hepatocellular carcinomas with interruption of segmental hepatic blood flow. J Vasc Interv Radiol 2002; 13:185–191.

    Article  PubMed  Google Scholar 

  201. Shibata T, Morita T, Okuyama M, Kitada M, Shimano T, Ishida T. [Comparison of percutaneous microwave coagulation area under interruption of hepatic arterial blood flow with that under hepatic arterial and venous blood flow for hepatocellular carcinoma]. Gan To Kagaku Ryoho 2002;29: 2146–2148.

    PubMed  Google Scholar 

  202. Wright AS, Lee FT, Jr., Mahvi DM. Hepatic microwave ablation with multiple antennae results in synergistically larger zones of coagulation necrosis. Ann Surg Oncol 2003;10:275–283.

    Article  PubMed  Google Scholar 

  203. Zhang J, Dong B, Liang P, et al. Significance of changes in local immunity in patients with hepatocellular carcinoma after percutaneous microwave coagulation therapy. Chin Med J (Engl) 2002;115:1367–1371.

    Google Scholar 

  204. Ohno T, Kawano K, Sasaki A, Aramaki M, Yoshida T, Kitano S. Expansion of an ablated site and induction of apoptosis after microwave coagulation therapy in rat liver. J Hepatobiliary Pancreat Surg 2001;8:360–366.

    Article  PubMed  CAS  Google Scholar 

  205. Mitsuzaki K, Yamashita Y, Nishiharu T, et al. CT appearance of hepatic tumors after microwave coagulation therapy. AJR Am J Roentgenol 1998;171:1397–1403.

    PubMed  CAS  Google Scholar 

  206. Xu H, Yie X, Lu MD. Ultrasound-guided percutaneous thermal ablation of hepatocellular carcinoma using microwave and radiofrequency ablation. Clin Radiol 2004;59:53–61.

    Article  PubMed  Google Scholar 

  207. Morita T, Shibata T, Okuyama M, et al. [Clinicopathological analysis of two patients with local recurrence after microwave coagulation therapy for liver metastases from colorectal cancer]. Gan To Kagaku Ryoho 2002;29:2234–2237.

    PubMed  Google Scholar 

  208. Dong B, Liang P, Yu X, et al. Percutaneous sonographically guided microwave coagulation therapy for hepatocellular carcinoma: results in 234 patients. AJR Am J Roentgenol 2003;180:1547–1555.

    PubMed  Google Scholar 

  209. Chen Y, Chen H, Wu M, et al. [Curative effect of percutaneous microwave coagulation therapy for hepatocellular carcinoma]. Zhonghua Zhong Liu Za Zhi 2002;24:65–67.

    PubMed  Google Scholar 

  210. Itamoto T, Asahara T, Kohashi T, et al. [Percutaneous microwave coagulation therapy for hepatocellular carcinoma]. Gan To Kagaku Ryoho 1999;26:1841–1844.

    PubMed  CAS  Google Scholar 

  211. Lu MD, Chen JW, Xie XY, et al. Hepatocellular carcinoma: US-guided percutaneous microwave coagulation therapy. Radiology 2001;221:167–172.

    Article  PubMed  CAS  Google Scholar 

  212. Seki T, Wakabayashi M, Nakagawa T, et al. Percutaneous microwave coagulation therapy for solitary metastatic liver tumors from colorectal cancer: a pilot clinical study. Am J Gastroenterol 1999;94: 322–327.

    Article  PubMed  CAS  Google Scholar 

  213. Seki T, Wakabayashi M, Nakagawa T, et al. Percutaneous microwave coagulation therapy for patients with small hepatocellular carcinoma: comparison with percutaneous ethanol injection therapy. Cancer 1999;85:1694–1702.

    Article  PubMed  CAS  Google Scholar 

  214. Beppu T, Ogawa M, Matsuda T, et al. [Efficacy of microwave coagulation therapy (MCT) in patients with liver tumors]. Gan To Kagaku Ryoho 1998;25:1358–1361.

    PubMed  CAS  Google Scholar 

  215. Matsukawa T, Yamashita Y, Arakawa A, et al. Percutaneous microwave coagulation therapy in liver tumors. A 3-year experience. Acta Radiol 1997;38:410–415.

    PubMed  CAS  Google Scholar 

  216. Sato M, Watanabe Y, Ueda S, et al. Microwave coagulation therapy for hepatocellular carcinoma. Gastroenterology 1996;110:1507–1514.

    Article  PubMed  CAS  Google Scholar 

  217. Liang P, Dong B, Yu D, et al. Prognostic factor for percutaneous microwave coagulation therapy of hepatic metastases. AJR Am J Roentgenol 2003;181:1319–1325.

    PubMed  Google Scholar 

  218. Ohmoto K, Miyake I, Tsuduki M, et al. Percutaneous microwave coagulation therapy for unresectable hepatocellular carcinoma. Hepatogastroenterology 1999;46:2894–2900.

    PubMed  CAS  Google Scholar 

  219. Shibata T, Niinobu T, Ogata N, Takami M. Microwave coagulation therapy for multiple hepatic metastases from colorectal carcinoma. Cancer 2000;89:276–284.

    Article  PubMed  CAS  Google Scholar 

  220. Abe T, Shinzawa H, Wakabayashi H, et al. Value of laparoscopic microwave coagulation therapy for hepatocellular carcinoma in relation to tumor size and location. Endoscopy 2000;32:598–603.

    Article  PubMed  CAS  Google Scholar 

  221. Takahashi Y, Shibata T, Shimano T, et al. [A case report of intra-thoracic biliary fistula after percutaneous microwave coagulation therapy]. Gan To Kagaku Ryoho 2000;27:1850–1853.

    PubMed  CAS  Google Scholar 

  222. Morimoto O, Nagano H, Sakon M, et al. Liver abscess formation after microwave coagulation therapy applied for hepatic metastases from surgically excised bile duct cancer: report of a case. Surg Today 2002;32:454–457.

    Article  PubMed  Google Scholar 

  223. Kojima Y, Suzuki S, Sakaguchi T, et al. Portal vein thrombosis caused by microwave coagulation therapy for hepatocellular carcinoma: report of a case. Surg Today 2000;30:844–848.

    Article  PubMed  CAS  Google Scholar 

  224. Sato M, Tokui K, Watanabe Y, et al. Generalized intraperitoneal seeding of hepatocellular carcinoma after microwave coagulation therapy: a case report. Hepatogastroenterology 1999;46:2561–2564.

    PubMed  CAS  Google Scholar 

  225. Matsumoto K, Beppu T, Ishiko T, Doi K, Ogawa M. [Liver and lung abscess after thoracoscopic microwave coagulation therapy for hepatocellular carcinoma]. Gan To Kagaku Ryoho 2002;29: 2225–2228.

    PubMed  Google Scholar 

  226. Shimada S, Hirota M, Beppu T, et al. A new procedure of percutaneous microwave coagulation therapy under artificial hydrothorax for patients with liver tumors in the hepatic dome. Surg Today 2001;31:40–44.

    Article  PubMed  CAS  Google Scholar 

  227. Okano H, Shiraki K, Inoue H, et al. Laparoscopic microwave coagulation therapy for small hepatocellular carcinoma on the liver surface. Oncol Rep 2002;9:1001–1004.

    PubMed  Google Scholar 

  228. David SL, Absolom DR, Smith CR, Gams J, Herbert MA. Effect of low level direct current on in vivo tumor growth in hamsters. Cancer Res 1985;45:5625–5631.

    PubMed  CAS  Google Scholar 

  229. Samuelsson L. Electrolysis and surgery in experimental tumors in the rat. Acta Radiol Diagn 1981;22:129–131.

    CAS  Google Scholar 

  230. Berendson J, Simonsson D. Electrochemical aspects of treatment of tissue with direct current. Eur J Surg Suppl 1994;574:111–115.

    Google Scholar 

  231. Heiberg E, Nalesnik WJ, Janney C. Effects of varying potential and electrolytic dosage in direct current treatment of tumors. Acta Radiol 1991;32:174–177.

    PubMed  CAS  Google Scholar 

  232. Nordenstrom BE. The paradigm of biologically closed electric circuits (BCEC) and the formation of an International Association (IABC) for BCEC systems. Eur J Surg Suppl 1994;574:7–23.

    Google Scholar 

  233. Nordenstrom BE. Survey of mechanisms in electrochemical treatment (ECT) of cancer. Eur J Surg Suppl 1994;574:93–109.

    Google Scholar 

  234. Robertson GS, Wemyss-Holden SA, Dennison AR, Hall PM, Baxter P, Maddern GJ. Experimental study of electrolysis-induced hepatic necrosis. Br J Surg 1998;85:1212–1216.

    Article  PubMed  CAS  Google Scholar 

  235. Wemyss-Holden SA, Robertson GS, Dennison AR, Vanderzon PS, Hall PM, Maddern GJ. A new treatment for unresectable liver tumors: long-term studies of electrolytic lesions in the pig liver. Clin Sci (Lond) 2000;98:561–567.

    CAS  Google Scholar 

  236. Samuelsson L, Olin T, Berg NO. Electrolytic destruction of lung tissue in therabbit. Acta Radiol Diagn 1980;21:447–454.

    CAS  Google Scholar 

  237. Wemyss-Holden SA, Berry DP, Robertson GS, Dennison AR, De La MHP, addern GJ. Electrolytic ablation as an adjunct to liver resection: safety and efficacy in patients. Aust N Z J Surg 2002;72: 589–593.

    Article  Google Scholar 

  238. Berry DP, Garcea G, Chung C, et al. Systemic reaction following electrolytic treatment of pig livers in vivo. Aust N Z J Surg 2004;74:586–590.

    Article  Google Scholar 

  239. Berry DP, Garcea G, Vanderzon P, et al. Augmenting the ablative effect of liver electrolysis; using multiple electrodes and the Pringle maneuver. J Invest Surg 2004;17:105–112.

    Article  PubMed  CAS  Google Scholar 

  240. Teague BD, Court FG, Morrison CP, Kho M, Wemyss-Holden S, Maddern GJ. Electrolytic liver ablation is not associated with evidence of a systemic inflammatory response syndrome. Br J Surg 2003;91:178–183.

    Article  Google Scholar 

  241. Finch JG, Fosh B, Anthony A, et al. Liver electrolysis: pH can reliably monitor the extent of hepatic ablation in pigs. Clin Sci (Lond) 2002;102:389–395.

    Article  Google Scholar 

  242. Berry DP, Dennison AR, Ward R, Maddern GJ. Electrolytic ablation of colorectal liver metastases: 1-year histological patient follow-up. Dig Surg 2000;17:518–519.

    Article  PubMed  CAS  Google Scholar 

  243. Fosh BG, Finch JG, Lea M, et al. Use of electrolysis as an adjunct to liver resection. Br J Surg 2002;89:999–1002.

    Article  PubMed  CAS  Google Scholar 

  244. Ravikumar TS, Steele GD Jr. Hepatic cryosurgery. Surg Clin North Am 1989;69:433–440.

    PubMed  CAS  Google Scholar 

  245. Cuschieri A, Crosthwaite G, Shimi S, et al. Hepatic cryotherapy for liver tumors. Development and clinical evaluation of a high-efficiency insulated multineedle probe system for open and laparoscopic use. Surg Endosc 1995;9:483–489.

    Article  PubMed  CAS  Google Scholar 

  246. Mala T, Aurdal L, Frich L, et al. Liver tumor ablation: a commentary on the need of improved procedural monitoring. Technol Cancer Res Treat 2004;3:85–91.

    PubMed  Google Scholar 

  247. Silverman SG, Sun MR, Tuncali K, et al. Three-dimensional assessment of MRI-guided percutaneous cryotherapy of liver metastases. AJR Am J Roentgenol 2004;183:707–712.

    PubMed  Google Scholar 

  248. Schuder G, Pistorius G, Schneider G, Feifel G. Preliminary experience with percutaneous cryotherapy of liver tumors. Br J Surg 1998;85:1210–1211.

    Article  PubMed  CAS  Google Scholar 

  249. Heniford BT, Arca MJ, Iannitti DA, Walsh RM, Gagner M. Laparoscopic cryoablation of hepatic metastases. Semin Surg Oncol 1998;15:194–201.

    Article  PubMed  CAS  Google Scholar 

  250. Hamad GG, Neifeld JP. Biochemical, hematologic, and immunologie alterations following hepatic cryotherapy. Semin Surg Oncol 1998;14:122–128.

    Article  PubMed  CAS  Google Scholar 

  251. Silverman SG, Tuncali K, Adams DF, et al. MR imaging-guided percutaneous cryotherapy of liver tumors: initial experience. Radiology 2000;217:657–664.

    PubMed  CAS  Google Scholar 

  252. Huang A, McCall JM, Weston MD, et al. Phase I study of percutaneous cryotherapy for colorectal liver metastasis. Br J Surg 2002;89:303–310.

    Article  PubMed  CAS  Google Scholar 

  253. Kollmar O, Richter S, Schilling MK, Menger MD, Pistorius G. Advanced hepatic tissue destruction in ablative cryosurgery: potentials of intermittent freezing and selective vascular inflow occlusion. Cryobiology 2004;48:263–272.

    Article  PubMed  Google Scholar 

  254. Mala T, Firch L, Aurdal L, et al. Hepatic vascular inflow occlusion enhances tissue destruction during cryoablation of porcine liver. J Surg Res 2003; 115:265–271.

    Article  PubMed  Google Scholar 

  255. Jungraithmayr W, Szarynski M, Neeff H, et al. Significance of total vascular exclusion for hepatic cryotherapy: an experimental study. J Surg Res 2004;116:32–41.

    Article  PubMed  CAS  Google Scholar 

  256. Ruers TJM, Joosten J, Jager GJ, Wobbes T. Long-term results in treating colorectal metastases with cryosurgery. Br J Surg 2001;88:844–849.

    Article  PubMed  CAS  Google Scholar 

  257. Mala T, Edwin B, Mathisen O, et al. Cryoablation of colorectal liver metastases: minimally invasive tumor control. Scand J Gastroenterol 2004;39:571–578.

    Article  PubMed  CAS  Google Scholar 

  258. Seifert JK, Heintz A, Junginger T. [Cryotherapy for primary and secondary liver tumors]. Zentralbl Chir 2002;127:275–281.

    Article  PubMed  CAS  Google Scholar 

  259. Sheen AJ, Poston GJ, Sherlock DJ. Cryotherapeutic ablation of liver tumors. Br J Surg 2002;89: 1396–1401.

    Article  PubMed  CAS  Google Scholar 

  260. Shimonov M, Shechter P, Victoria F, Ada R, Henri H, Czerniak A. [Laparoscopic cryoablation of liver tumors]. Harefuah 2002; 141:414–417, 500.

    PubMed  Google Scholar 

  261. Chung MH, Ye W, Ramming KP, Bilchik AJ. Repeat hepatic cryotherapy for metastatic colorectal cancer. J Gastrointest Surg 2001;5:287–293.

    Article  PubMed  CAS  Google Scholar 

  262. Seifert JK, Achenbach T, Heintz A, Bottger TC, Junginger T. Cryotherapy for liver metastases. Int J Colorectal Dis 2000;15:161–166.

    Article  PubMed  CAS  Google Scholar 

  263. Shapiro RS, Shafir M, Sung M, Warner R, Glajchen N. Cryotherapy of metastatic carcinoid tumors. Abdom Imaging 1998;23:314–317.

    Article  PubMed  CAS  Google Scholar 

  264. Zhou XD, Tang ZY. Cryotherapy for primary liver cancer. Semin Surg Oncol 1998;14:171–174.

    Article  PubMed  CAS  Google Scholar 

  265. Weaver ML, Ashton JG, Zemel R. Treatment of colorectal liver metastases by cryotherapy. Semin Surg Oncol 1998;14:163–170.

    Article  PubMed  CAS  Google Scholar 

  266. Hewitt PM, Dwerryhouse SJ, Zhao J, Morris DL. Multiple bilobar liver metastases: cryotherapy for residual lesions after liver resection. J Surg Oncol 1998;67:112–116.

    Article  PubMed  CAS  Google Scholar 

  267. Junginger T, Seifert JK, Weigel TF, Heintz A, Kreitner KF, Gerharz CD. [Cryotherapy of liver metastases. Initial results]. Med Klin 1998;93:517–523.

    Article  CAS  Google Scholar 

  268. Weaver ML, Atkinson D, Zemel R. Hepatic cryosurgery in treating colorectal metastases. Cancer 1995;76:210–214.

    Article  PubMed  CAS  Google Scholar 

  269. Rivoire M, De Cian F, Meeus P, Negrier S, Sebban H, Kaemmerlen P. Combination of neoadjuvant chemotherapy with cryotherapy and surgical resection for the treatment of unresectable liver metastases from colorectal carcinoma. Cancer 2002;95:2283–2292.

    Article  PubMed  CAS  Google Scholar 

  270. Finlay IG, Seifert JK, Stewart GJ, Morris DL. Resection with cryotherapy of colorectal hepatic metastases has the same survival as hepatic resection alone. Eur J Surg Oncol 2000;26:199–202.

    Article  PubMed  CAS  Google Scholar 

  271. Seifert JK, Morris DL. Cryotherapy of the resection edge after liver resection for colorectal cancer metastases. Aust N Z J Surg 1998;68:725–728.

    PubMed  CAS  Google Scholar 

  272. Gruenberger T, Jourdan JL, Zhao J, King J, Morris DL. Reduction in recurrence risk for involved or inadequate margins with edge cryotherapy after liver resection for colorectal metastases. Arch Surg 2001;136:1154–1157.

    Article  PubMed  CAS  Google Scholar 

  273. Preketes A, Caplehorn JR, King J, Clingan PR, Ross WB, Morris DL. Effect of hepatic artery chemotherapy on survival of patients with hepatic metastases from colorectal carcinoma treated with cryotherapy. World J Surg 1995;19:768–771.

    Article  PubMed  CAS  Google Scholar 

  274. Morris DL, Horton MD, Dilley AV, Walters A, Clingan PR. Treatment of hepatic metastases by cryotherapy and regional cytotoxic perfusion. Gut 1993;34:1156–1157.

    Article  PubMed  CAS  Google Scholar 

  275. Allen-Mersh TG, Earlam S, Fordy C, Abrams K, Houghton J. Quality of life and survival with continuous hepatic-artery floxurinde infusion for colorectal liver metastases. Lancet 1994;344: 1255–1260.

    Article  PubMed  CAS  Google Scholar 

  276. Rougier P, Laplanche A, Hughuier M, May JM, Ollivier JM, Escat J. Hepatic arterial infusion of floxuridine in patients with liver mestases from colorectal carcinoma; long-term results of a prospective randomized trial. J Clin Oncol 1992; 10:1112–1118.

    PubMed  CAS  Google Scholar 

  277. Xu KC, Nil LZ, He WB, Guo ZQ, Hu YZ, Juo JS. Percutaneous cryoablation in combination with ethanol injection for unresectable hepatocellular carcinoma. World J Gastroenterol 2003;9: 2686–2689.

    PubMed  Google Scholar 

  278. Qian GJ, Chen H, Wu MC. Percutaneous cryoablation after chemoembolisation of liver carcinoma: a report of 34 cases. Hepatobiliary Pancreatic Dis Int 2003;2:520–524.

    Google Scholar 

  279. Seifert JK, Junginger T, Morris DL. [Diameter of metastases is decisive for local treatment outcome of cryotherapy of colorectal liver metastases]. Langenbecks Arch Chir Suppl Kongressbd 1998;115:1455–1457.

    PubMed  CAS  Google Scholar 

  280. Seifert JK, Morris DL. Indicators of recurrence following cryotherapy for hepatic metastases from colorectal cancer. Br J Surg 1999;86:234–240.

    Article  PubMed  CAS  Google Scholar 

  281. Adam R, Akpinar E, Johann M, Kunstlinger F, Majno P, Bismuth H. Place of cryosurgery in the treatment of malignant liver tumors. Ann Surg 1997;225:39–48; discussion 48-50.

    Article  PubMed  CAS  Google Scholar 

  282. Seifert JK, Junginger T. Prognostic factors for cryotherapy of colorectal liver metastases. Eur JSurg Oncol 2004;30:34–40.

    Article  CAS  Google Scholar 

  283. Preketes AP, King J, Caplehorn JR, Clingan PR, Ross WB, Morris DL. CEA reduction after cryotherapy for liver metastases from colon cancer predicts survival. Aust N Z J Surg 1994;64:612–614.

    PubMed  CAS  Google Scholar 

  284. Morris DL, Ross WB, Iqbal J, McCall J, King J, Clingan PR. Cryoablation of hepatic malignancy. An evaluation of tumor marker data and survival in 110 patients. GI Cancer 1996; 1:247–251.

    Google Scholar 

  285. Wallis CB, Coventry DM. Anaesthetic experience with laparoscopic cryotherapy. A new technique for treating liver metastases. Surg Endosc 1997;11:979–981.

    Article  PubMed  CAS  Google Scholar 

  286. Iannitti DA, Heniford T, Hale J, Grundfest-Broniatowski S, Gagner M. Laparoscopic cryoablation of hepatic metastases. Arch Surg 1998;133:1011–1015.

    Article  PubMed  CAS  Google Scholar 

  287. Soon PS, Glenn D, Jorgensen J, Morris DL. Fluorodeoxyuridine causes bilomas after hepatic cryotherapy. J Surg Oncol 1998;69:45–50.

    Article  PubMed  CAS  Google Scholar 

  288. Seifert JK, Morris DL. World survey on the complications of hepatic and prostate cryotherapy. World J Surg 1999;23:109–113; discussion 13-14.

    Article  PubMed  CAS  Google Scholar 

  289. Seifert JK, Stewart GJ, Hewitt PM, Bolton EJ, Junginger T, Morris DL. Interleukin-6 and tumor necrosis factor-alpha levels following hepatic cryotherapy: association with volume and duration of freezing. World J Surg 1999;23:1019–1026.

    Article  PubMed  CAS  Google Scholar 

  290. Ng KK, Lam CM, Poon RT, et al. Comparison of systemic responses of radiofrequency ablation, cryotherapy and surgical resection in a porcine liver model. Ann Surg Oncol 2004;11:650–657.

    Article  PubMed  Google Scholar 

  291. Garcea G, Polomenovi N, O’Leary E, Lloyd TD, Dennison A, Berry DP. Two-stage liver resection and chemotherapy for bilobar liver metastases. Eur J Surg Oncology 2004;30:759–764.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. The Robert Kilpatrick Clinical Sciences Building, The Leicester Royal Infirmary, Leicester, UK

    Giuseppe Garcea MD

  2. National Cancer Institute, Bethesda, MD

    David P. Berry MD

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Editors and Affiliations

  1. Robert-Rössle-Hospital and Tumor Institute, Charité University of Medicine, Berlin

    Peter M. Schlag MD (Professor and Head of Surgical Oncology) (Professor and Head of Surgical Oncology)

  2. Max-Delbrück-Center for Molecular Medicine, Berlin, Germany

    Peter M. Schlag MD (Professor and Head of Surgical Oncology) & Ulrike Stein PhD (Assistant Professor) (Professor and Head of Surgical Oncology) &  (Assistant Professor)

  3. Tumor Metastasis and Therapy Response Program, Robert-Rössle-Hospital and Tumor Institute, Charité University of Medicine, Berlin

    Ulrike Stein PhD (Assistant Professor) (Assistant Professor)

  4. Erasmus University MC—Daniel den Hoed Cancer Center, Rotterdam, The Netherlands

    Alexander M. M. Eggermont MD, PhD (Professor and Head of Surgical Oncology) (Professor and Head of Surgical Oncology)

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Garcea, G., Berry, D.P. (2007). Focal Liver Ablation Techniques in Primary and Secondary Liver Tumors. In: Schlag, P.M., Stein, U., Eggermont, A.M.M. (eds) Regional Cancer Therapy. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-225-0_14

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