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Molecular Imaging

Noninvasive Strategies to Visualize Gene Expression in Living Subjects

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Book cover Prostate Cancer

Part of the book series: Contemporary Cancer Research ((CCR))

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Abstract

Recent advances in molecular imaging techniques have opened the door to a new universe that allows for early detection and characterization of disease and evaluation of therapy. Noninvasive imaging of reporter gene expression using different imaging modalities has proved to be valuable for the in vivo assessment of molecular events in several areas including reporter gene expression, immune cell trafficking, protein—protein interactions, and cancer gene therapy. Multimodality imaging offers the advantage of monitoring the expression of multiple genes using different imaging modalities and finds applications in many areas of biology and medicine. In the coming years, molecular imaging will play a key role in the screening of novel drugs and in the understanding of disease progression at the cellular and molecular level. This chapter provides a comprehensive review of different reporter gene imaging strategies, imaging modalities, and applications of molecular imaging for cancer gene therapy. The chapter also includes a discussion of transcriptional targeting using tissue-specific promoters, including prostate cancer imaging. The final section includes a brief review of the developments in viral and nonviral gene delivery.

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Authors and Affiliations

  1. The Crump Institute for Molecular Imaging and Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA

    Meera Iyer PhD & Sanjiv S. Gambhir MD, PhD

  2. Departments of Radiology and Bioengineering Bio-X Program, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA

    Sanjiv S. Gambhir MD, PhD

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  1. Meera Iyer PhD
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  1. Emory University School of Medicine, Atlanta, GA

    Leland W. K. Chung PhD

  2. Johns Hopkins University School of Medicine, Baltimore, MD

    William B. Isaacs PhD

  3. Prostate Cancer Foundation, Santa Monica, CA

    Jonathan W. Simons MD

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Iyer, M., Gambhir, S.S. (2007). Molecular Imaging. In: Chung, L.W.K., Isaacs, W.B., Simons, J.W. (eds) Prostate Cancer. Contemporary Cancer Research. Humana Press. https://doi.org/10.1007/978-1-59745-224-3_12

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