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Autophagy and Autophagic Cell Death

  • Chapter
Apoptosis, Senescence, and Cancer

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Summary

Macroautophagy or autophagy is a degradative pathway terminating in the lysosomal compartment after the formation of a cytoplasmic vacuole that engulfs macromolecules and organelles. During the last decade, progress made in our understanding of the molecular controls of autophagy has uncovered the importance of tumor suppressor molecules in the stimulation of autophagy. Downexpression of autophagy is an early event during tumorigenesis. However, the relation between autophagy and tumor progression seems to be more complex because cancer cells are able to trigger autophagy in response to various situations including changes in their extracellular environment and cancer treatments. The role of autophagy in cancer cells balances between two apparently opposite outcomes. Autophagy as a stress response mechanism can protect cancer cells from various insults. But autophagy can eliminate cancer cells by triggering autophagic cell death. These two aspects of autophagy will be discussed in this review.

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Authors
  1. Mojgan Djavaheri-Mergny PhD
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  2. Joëlle Botti PhD
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  3. Patrice Codogno PhD
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Editor information

Editors and Affiliations

  1. Department of Pharmacology and Toxicology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA

    David A. Gewirtz

  2. Departments of Medicine, Pharmacology and Toxicology, Biochemistry and Massey Cancer Center, Virginia Commonwealth, Richmond, VA

    Shawn E. Holt

  3. Departments of Pathology, Human Genetics, Pharmacology and Toxicology, Biochemistry and Massey Cancer Center, Virginia Commonwealth, Richmond, VA

    Steven Grant

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© 2007 Humana Press Inc.

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Djavaheri-Mergny, M., Botti, J., Codogno, P. (2007). Autophagy and Autophagic Cell Death. In: Gewirtz, D.A., Holt, S.E., Grant, S. (eds) Apoptosis, Senescence, and Cancer. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-221-2_5

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  • DOI: https://doi.org/10.1007/978-1-59745-221-2_5

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-527-9

  • Online ISBN: 978-1-59745-221-2

  • eBook Packages: MedicineMedicine (R0)

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