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Nano-Sized Carriers for Drug Delivery

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NanoBioTechnology

Abstract

Drug delivery is an important issue, especially with a new generation of therapeutics, which are either unstable in the biological environment, have poor transport properties across biological membranes, are insoluble in water, or have very low bioavailability. Nano-sized drug carriers can address some of the above issues and enhance their therapeutic efficacy. Different types of nano-sized carriers, such as nanoparticles, nanowires, nanocages, dendrimers, etc., are being developed for various drug-delivery applications. The challenge is to determine the therapeutic dose of the drug formulated in a system, which could be significantly different from that of the drug nanocarrier. In this regard, a better understanding of the pathophysiology of the disease condition under consideration is critical so that one can select and design an appropriate drug carrier system that would deliver a therapeutic dose of the drug in the target tissue or a body compartment at a rate and for the duration that is therapeutically effective and can cure the disease.

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Authors and Affiliations

  1. Institute of Life Sciences, Nalco Square, Bhubaneswar, Orissa, India

    Sanjeeb K. Sahoo

  2. Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE

    Tapan K. Jain

  3. Department of Biomedical Engineering, Lemer Research Institute, Cleveland Clinic, Cleveland, OH

    Maram K. Reddy & Vinod Labhasetwar

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  1. Sanjeeb K. Sahoo
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  2. Tapan K. Jain
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  3. Maram K. Reddy
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  4. Vinod Labhasetwar
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Editors and Affiliations

  1. The Institute of Plant Science and Genetics in Agriculture and The Otto Warburg Center for Agricultural Biotechnology, The Hebrew University of Jerusalem, Rehovot, Israel

    Oded Shoseyov

  2. Intel Electronics, Intel Research Israel, Jerusalem, Israel

    Ilan Levy

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Sahoo, S.K., Jain, T.K., Reddy, M.K., Labhasetwar, V. (2008). Nano-Sized Carriers for Drug Delivery. In: Shoseyov, O., Levy, I. (eds) NanoBioTechnology. Humana Press. https://doi.org/10.1007/978-1-59745-218-2_13

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