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Neuroprotective Factors and Retinal Degenerations

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Book cover Retinal Degenerations

Part of the book series: Ophthalmology Research ((OPHRES))

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Abstract

Mammalian neurons are postmitotic and, in general, are nonrenewable, so an individual cell must be capable of surviving a wide range of environmental conditions for many decades, if not a lifetime. Retinal neurons are isolated to some extent from fluctuations in levels of many circulating molecules by a specific blood-retinal barrier, a structure analogous to the blood-brain barrier elsewhere in the central nervous system (CNS). This barrier provides protection to the retina by selectively transporting those molecules required for normal metabolism and filtering out components that could be detrimental to the health of the tissue.

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  1. Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT

    Joyce Tombran-Tink PhD & Colin J. Barnstable DPhil

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  1. Joyce Tombran-Tink PhD
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  2. Colin J. Barnstable DPhil
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  1. Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT

    Joyce Tombran-Tink PhD  & Colin J. Barnstable DPhil  & 

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Tombran-Tink, J., Barnstable, C.J. (2007). Neuroprotective Factors and Retinal Degenerations. In: Tombran-Tink, J., Barnstable, C.J. (eds) Retinal Degenerations. Ophthalmology Research. Humana Press. https://doi.org/10.1007/978-1-59745-186-4_23

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  • DOI: https://doi.org/10.1007/978-1-59745-186-4_23

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