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Imaging Tumor Biology

Physiological and Molecular Insights

  • Chapter
High-Grade Gliomas

Part of the book series: Current Clinical Oncology ((CCO))

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Abstract

Anatomic medical imaging offers the ability to detect and delineate brain tumors. In addition, emerging techniques (in particular MRI variants) offer insight into aspects of tumor physiology and metabolism, thus allowing characterization of tumor dysfunction, in principle, at a metabolic, cellular, and vascular level. This chapter will present advances in faster and higher resolution magnetic resonance spectroscopic imaging (MRSI) as a probe of abnormal metabolism; diffusion weighted imaging (DWI) as a measure of tumor cellularity, and the related technique of diffusion tensor imaging (DTI) as a measure of structural organization; and, imaging of tumor perfusion and vascular permeability, as a measure of vascularity and as an approach to the study of angiogenesis.

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Author information

Authors and Affiliations

  1. Department of Medical Imaging, University of Toronto, University Health Network; and Toronto Western Research Institute, Toronto, Ontario

    Timothy P. L. Roberts

  2. Department of Medical Imaging, University of Toronto, University Health Network, Toronto, Ontario

    Andrea Kassner

Authors
  1. Timothy P. L. Roberts
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  2. Andrea Kassner
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Editor information

Editors and Affiliations

  1. Department of Neurological Surgery Cleveland Clinic Foundation, Brain Tumor Institute, Cleveland, OH

    Gene H. Barnett MD

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© 2007 Humana Press Inc., Totowa, NJ

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Roberts, T.P.L., Kassner, A. (2007). Imaging Tumor Biology. In: Barnett, G.H. (eds) High-Grade Gliomas. Current Clinical Oncology. Humana Press. https://doi.org/10.1007/978-1-59745-185-7_8

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  • DOI: https://doi.org/10.1007/978-1-59745-185-7_8

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-511-8

  • Online ISBN: 978-1-59745-185-7

  • eBook Packages: MedicineMedicine (R0)

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