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Endothelial Precursor Cells

  • Chapter
Antiangiogenic Agents in Cancer Therapy

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Summary

The recognition that blood vessel growth is a critical process in developing tumors has led to the increased study of tumor vasculature. Originally, it was considered that only nearby host vasculature provided the necessary cellular components that comprise blood vessels, endothelial cells (EC), and pericytes. Data gathered in recent years have supported the notion that endothelial precursor cells (EPC) exist postnatal and that EPC can also contribute to both physiological and pathological angiogenic processes including wound healing and cancer. EPC possess or can acquire many of the characteristics of mature, fully differentiation EC such as the ability to form tubes, to incorporate into developing vasculature, and to express many EC markers such as vascular endothelial growth factor 2 (VEGFR2) or von Willebrand factor (vWF). The most primitive EPC exhibit properties of progenitor cells that are denoted by expression of the hematopoietic stem cell marker CD34 and typically co-expressing CD133. Experiments in genetically engineered mice have demonstrated recruitment of cells from bone marrow to tumor vasculature. Studies in humans have also proven the existence of EPC. Although EPC represent a small percentage of the EC population, these progenitor cells offer new insights into tumor biology and may reveal novel targets for drug development.

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  1. Rebecca G. Bagley MS
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  1. Genzyme Corporation, Framingham, MA

    Beverly A. Teicher PhD

  2. M. D. Anderson Cancer Center, The University of Texas, Houston, TX

    Lee M. Ellis MD

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© 2008 Humana Press

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Bagley, R.G. (2008). Endothelial Precursor Cells. In: Teicher, B.A., Ellis, L.M. (eds) Antiangiogenic Agents in Cancer Therapy. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-184-0_6

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  • DOI: https://doi.org/10.1007/978-1-59745-184-0_6

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