Abstract
Gastric polyps are a frequent incidental finding during endoscopy that occasionally present with bleeding, obstruction, or pain. The majority are non-neoplastic. The major epithelial polyps are fundic gland, hyperplastic, and adenomatous. Sporadic fundic gland polyps (FGPs) are benign and have no malignant potential. Hyperplastic and adenomatous polyps may arise in a background of Helicobacter pylori infection and have malignant potential; these should be endoscopically removed. Gastric polyps can also be seen as a manifestation of polyposis syndromes most notably familial adenomatous polyposis (FAP; FGPs and to a lesser degree adenomatous), Peutz Jegher’s syndrome (harmatomas), and juvenile polyposis (hamartomas). Patients with familial polyposis may be at an increased risk of gastric cancer, particularly those with Peutz-Jegher’s syndrome. Endoscopic polypectomy is safe and effective but carries a higher complication rate than polypectomy in the colon.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Ghazi A, Ferstenberg H, Shinya H. Endoscopic gastroduodenal polypectomy. Ann Surg 1984; 200:175–180.
Archimandritis A, Spiliadis C, Tzivras M, et al. Gastric epithelial polyps: a retrospective endoscopic study of 12974 symptomatic patients. Ital J Gastroenterol 1996; 28:387–390.
Dekker W. Clinical Relevance of gastric and duodenal polyps. Scand J Gastroenterol Suppl 1990; 178:7–12.
Stolte M, Sticht T, Eidt S, Ebert D, Finkenzeller G. Frequency, location, and age and sex distribution of various types of gastric polyp. Endoscopy1994; 26:659–665.
Haruma K, Sumii K, Yoshihara M, Watanabe C, Kajiyama G. Gastric mucosa in female patients with fundic gland polyps. J Clin Gastroenterol 1991; 13:565–569.
Watanabe H, Enjoji M, Yao T, Ohsato K. Gastric lesions in familial adenomatosis coli: their incidence and histologic analysis. Hum Pathol 1978; 9:269–283.
Church JM, McGannon E, Hull-Boiner S, et al. Gastroduodenal polyps in patients with familial adenomatous polyposis. Dis Colon Rectum 1992; 35:1170–1173.
Odze RD, Marcial MA, Antonioli D. Gastric fundic gland polyps: a morphological study including mucin histochemistry, stereometry, and MIB-1 immunohistochemistry. Hum Pathol 1996; 27: 896–903.
Abraham SC, Nobukawa B, Giardiello FM, Hamilton SR, Wu TT. Fundic gland polyps in familial adenomatous polyposis: neoplasms with frequent somatic adenomatous polyposis coli gene alterations. Am J Pathol 2000; 157:747–754.
Abraham SC, Nobukawa B, Giardiello FM, Hamilton SR, Wu TT. Sporadic fundic gland polyps: common gastric polyps arising through activating mutations in the beta-catenin gene. Am J Pathol 2001; 158:1005–1010.
Abraham SC, Park SJ, Mugartegui L, Hamilton SR, Wu TT. Sporadic fundic gland polyps with epithelial dysplasia: evidence for preferential targeting for mutations in the adenomatous polyposis coli gene. Am J Pathol 2002; 161:1735–1742.
Wu TT, Kornacki S, Rashid A, Yardley JH, Hamilton SR. Dysplasia and dysregulation of proliferation in foveolar and surface epithelia of fundic gland polyps from patients with familial adenomatous polyposis. Am J Surg Pathol 1998; 22:293–298.
Bertoni G, Sassatelli R, Nigrisoli E, et al. Dysplastic changes in gastric fundic gland polyps of patients with familial adenomatous polyposis. Ital J Gastroenterol Hepatol 1999; 31:192–197.
Coffey RJ Jr, Knight CD Jr, van Heerden JA, Weiland LH. Gastric adenocarcinoma complicating Gardner’s syndrome in a North American woman. Gastroenterology 1985; 88:1263–1266.
Goodman AJ, Dundas SA, Scholefield JH, Johnson BF. Gastric carcinoma and familial adenomatous polyposis (FAP). Int J Colorectal Dis 1988; 3:201–203.
Zwick A, Munir M, Ryan CK, et al. Gastric adenocarcinoma and dysplasia in fundic gland polyps of a patient with attenuated adenomatous polyposis coli. Gastroenterology 1997; 113:659–663.
Hofgartner WT, Thorp M, Ramus MW, et al. Gastric adenocarcinoma associated with fundic gland polyps in a patient with attenuated familial adenomatous polyposis. Am J Gastroenterol 1999; 94:2275–2281.
Jung A, Vieth M, Maier O, Stolte M. Fundic gland polyps (Elster’s cysts) of the gastric mucosa. A marker for colorectal epithelial neoplasia? Pathol Res Pract 2002; 198:731–734.
Sakai N, Tatsuta M, Hirasawa R, et al. Low prevalence of H. pylori infection in patients with hamartomatous fundic polyps. Dig Dis Sci 1998; 43:766–772.
Watanabe N, Seno H, Nakajima T, et al. Regression of fundic gland polyps following acquisition of Helicobacter pylori. Gut 2002; 51:742–745.
el-Zimaity HM, Jackson FW, Graham DY. Fundic gland polyps developing during omeprazole therapy. Am J Gastroenterol 1997; 92:1858–1860.
Choudhry U, Boyce HW Jr, Coppola D. Proton pump inhibitor-associated gastric polyps: a retrospective analysis of their frequency, and endoscopic, histologic, and ultrastructural characteristics. Am J Clin Pathol 1998; 110:615–621.
Vieth M, Stolte M. Fundic gland polyps are not induced by proton pump inhibitor therapy. Am J Clin Pathol 2001; 116:716–20.
Weston BR, Helper DJ, Rex DK. Positive predictive value of endoscopic features deemed typical of gastric fundic gland polyps. J Clin Gastroenterol 2003; 36:399–402.
Kazantsev GB, Schwesinger WH, Heim-Hall J. Spontaneous resolution of multiple fundic gland polyps after cessation of treatment with lansoprazole and Nissen fundoplication: a case report. Gastrointest Endosc 2002; 55:600–602.
Eidt S, Stolte M. Gastric glandular cysts—investigations into their genesis and relationship to colorectal epithelial tumors. Z Gastroenterol 1989; 27:212–217.
Orlowska J, Jarosz D, Pachlewski J, Butruk E. Malignant transformation of benign epithelial gastric polyps. Am J Gastroenterol 1995; 90:2152–2159.
Oberhuber G Stolte M. Gastric polyps: an update of their pathology and biological significance. Virchows Arch 2000; 437: 581–590.
Cerwenka H, Bacher H, Mischinger HJ. Pyloric obstruction caused by prolapse of a hyperplastic gastric polyp. Hepatogastro-enterology 2002; 49:958–960.
Gencosmanoglu R, Sen-Oran E, Kurtkaya-Yapicier O, Tozun N. Antral hyperplastic polyp causing intermittent gastric outlet obstruction: case report. BMC Gastroenterol 2003; 3:16.
Ljubicic N Banic M, Kujundzic M, et al. The effect of eradicating Helicobacter pylori infection on the course of adenomatous and hyperplastic gastric polyps. Eur J Gastroenterol Hepatol 1999; 11:727–730.
Ohkusa T, Takashimizu I, Fujiki K, et al. Disappearance of hyperplastic polyps in the stomach after eradication of Helicobacter pylori. A randomized, clinical trial. Ann Intern Med 1998; 129:712–715.
Metz DC. Hyperplastic gastric polyps: medical management is feasible. Am J Gastroenterol 1999; 94:1977–1978.
Ohkusa T, Miwa H, Hojo M, et al. Endoscopic, histological and serologic findings of gastric hyperplastic polyps after eradication of Helicobacter pylori: comparison between responder and non-responder cases. Digestion 2003; 68:57–62.
Geller A, Gostout CJ, Balm RK. Development of hyperplastic polyps following laser therapy for watermelon stomach. Gastrointest Endosc 1996; 43:54–56.
Yoshikane H, Asai T, Sakakibara A, et al. Gastric hyperplastic polyp occurring at the resection site of gastric adenoma. Endoscopy 1999; 31:563–565.
Amaro R, Neff GW, Karnam US, Tzakis AG, Raskin JB. Acquired hyperplastic gastric polyps in solid organ transplant patients. Am J Gastroenterol 2002; 97:2220–2224.
Daibo M, Itabashi M, Hirota T. Malignant transformation of gastric hyperplastic polyps. Am J Gastroenterol 1987; 82:1016–1025.
Zea-Iriarte WL, Sekine I, Itsuno M, et al. Carcinoma in gastric hyperplastic polyps. A phenotypic study. Dig Dis Sci 1996; 41:377–386.
Ginsberg GG, Al-Kawas FH, Fleischer DE, Reilly HF, Benjamin SB. Gastric polyps: relationship of size and histology to cancer risk. Am J Gastroenterol 1996 91:714–717.
Deppisch LM, Rona VT. Gastric epithelial polyps. A 10-year study. J Clin Gastroenterol 1989; 11:110–115.
Snover DC. Benign epithelial polyps of the stomach. Pathol Annu 1985; 20:303–329.
Seifert E, Gail K, Weismuller J. Gastric polypectomy. Long-term results (survey of 23 centres in Germany). Endoscopy 1983; 15:8–11.
Harju E. Gastric polyposis and malignancy. Br J Surg 1986; 73:532–533.
Rattan J, Arber N, Tiomny E, et al. Gastric polypoid lesions—an eight-year study. Hepatogastroenterology 1993 40:107–109.
Nakamura K, Sakaguchi H, Enjoji M. Depressed adenocarcinoma of the stomach. Cancer1988; 62:2197–202.
Abraham SC, Montgomery EA, Singh VK, Yardley JH, Wu TT. Gastric adenomas: intestinal-type and gastric-type adenomas differ in the risk of adenocarcinoma and presence of background mucosal pathology. Am J Surg Pathol 2002; 26:1276–1285.
Vieth M, Kushima R, Borchard F, Stolte M. Pyloric gland adenoma: a clinico-pathological analysis of 90 cases. Virchows Arch 2003; 442(4):317–321.
Nakamura T, Nakano G. Histopathological classification and malignant change in gastric polyps. J Clin Pathol 1985; 38:754–764.
Kolodziejczyk P, Yao T, Oya M, et al. Long-term follow-up study of patients with gastric adenomas with malignant transformation. An immunohistochemical and histochemical analysis. Cancer 1994; 74:2896–2907.
Stolte M. Clinical consequences of the endoscopic diagnosis of gastric polyps. Endoscopy 1995; 27:32–37; discussion 59,60.
Park DI, Rhee PL, Kim JE, et al. Risk factors suggesting malignant transformation of gastric adenoma: univariate and multivariate analysis. Endoscopy 2001; 33:501–506.
Tomasulo J. Gastricpolyps. Histologic types and their relationship to gastric carcinoma. Cancer 1971; 27:1346–1355.
Cristallini EG, Ascani S, Bolis GB. Association between histologic type of polyp and carcinoma of the stomach. Gastrointest Endosc 1992; 38:481–484.
Antonioli DA. Precursors of gastric carcinoma: a critical review with a brief description of early (curable) gastric cancer. Hum Path 1994 25:994–1005.
Offerhaus GJ, Giardiello FM, Krush AJ, et al. The risk of upper gastrointestinal cancer in familial adenomatous polyposis. Gastroenterology 1992; 102:1980–1982.
Marcello PW, Asbun HJ, Veidenheimer MC, et al. Gastroduodenal polyps in familial adenomatous polyposis. Surg Endosc 1996; 10:418–421.
Jagelman DG, DeCosse JJ, Bussey HJ. Upper gastrointestinal cancer in familial adenomatous polyposis. Lancet 1988; 1(8595): 1149–1151.
Yamagata S, Hisamichi S. Precancerous lesions of the stomach. World J Surg 1979; 3:671–673.
Laxen F. Gastric carcinoma and pernicious anemia in long-term endoscopic follow-up of subjects with gastric polyps. Scand J Gastroenterol 1984; 19:535–540.
Shalom A, Wasserman I, Segal M, Orda R. Inflammatory fibroid polyp and Helicobacter pylori. Aetiology or coincidence? Eur J Surg 2000; 166:54–57.
Stolte M, Finkenzeller G. Inflammatory fibroid polyp of the stomach. Endoscopy 1990; 22:203–207.
Adachi MM, Iida M, Tsuneyoshi M, Sugimachi K. Inflammatory fibroid polyp of the stomach. Report of three unusual cases. J Clin Gastroenterol 1992; 15:154–158.
Shigeno T, Fujimori K, Nakatsuji Y, Kaneko Y, Maejima T. Gastric inflammatory fibroid polyp manifesting massive bleeding and marked morphological changes for a short period. J Gastroenterol 2003; 38:611,612.
Tada S, Iida M, Yao T, et al. Endoscopic removal of inflammatory fibroid polyps of the stomach. Am J Gastroenterol 1991; 86: 1247–1250.
Schmeck-Lindenau HJ, Kurtz W, Heine M. Inflammatory polyps: an unreported side effect of argon plasma coagulation. Endoscopy 1998; 30:S93,S94.
Varis O, Laxen F, Valle J. Helicobacter pylori infection and fasting serum gastrin levels in a series of endoscopically diagnosed gastric polyps. Acta Path Micro Immunol Scand 1994; 102:759–764.
Mori M, Tamura S, Enjoji M, Sugimachi K. Concomitant presence of inflammatory fibroid polyp and carcinoma or adenoma in the stomach. Arch Pathol Lab Med 1988; 112:829–832.
Hizawa K, Iida M, Tada S, et al. Endoscopic evaluation of gastric inflammatory fibroid polyp. Surg Endosc 1995; 9:397–400.
Matsushita M, Hajiro K, Okazaki K, Takakuwa H. Gastric inflammatory fibroid polyps: endoscopic ultrasonographic analysis in comparison with the histology. Gastrointest Endosc 1997; 46:53–57.
Zinkiewicz K, Zgodzinski W, Dabrowski A, Szumilo J, Cwik G, Wallner G. Recurrent inflammatory fibroid polyp of cardia: a case report. World J Gastroenterol 2004; 10:767,768.
Jarvinen HJ, Sipponen P. Gastroduodenal polyps in familial adenomatous and juvenile polyposis. Endoscopy 1986; 18:230–234.
Jarvinen H, Nyberg M, Peltokallio P. Upper gastrointestinal tract polyps in familial adenomatosis coli. Gut 1983; 24:333–339.
Domizio P, Talbot IC, Spigelman AD, Williams CB, Phillips RK. Upper gastrointestinal pathology in familial adenomatous polyposis: results from a prospective study of 102 patients. J Clin Pathol 1990; 43:738–743.
Goedde TA, Rodriguez-Bigas MA, Herrera L, Petrelli NJ. Gastroduodenal polyps in familial adenomatous polyposis. Surg Oncol 1992; 1:357–361.
Giardiello FM, Offerhaus GJ, DuBois RN. The role of nonsteroidal anti-inflammatory drugs in colorectal cancer prevention. Eur J Cancer 1995; 31A:1071–1076.
Steinbach G, Lynch PM, Phillips RK, et al. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N Engl J Med 2000; 342:1946–1952.
Labayle D, Fischer D, Vielh P, et al. Sulindac causes regression of rectal polyps in familial adenomatous polyposis. Gastroenterology 1991; 101:635–639.
Nugent KP, Farmer KC, Spigelman AD, Williams CB, Phillips RK. Randomized controlled trial of the effect of sulindac on duodenal and rectal polyposis and cell proliferation in patients with familial adenomatous polyposis. Br J Surg 1993; 80:1618, 1619.
Seow-Choen F, Vijayan V, Keng V. Prospective randomized study of sulindac versus calcium and calciferol for upper gastrointestinal polyps in familial adenomatous polyposis. Br J Surg 1996; 83:1763–1766.
Anonymous. The role of endoscopy in the surveillance of prema-lignant conditions of the upper gastrointestinal tract. American Society for Gastrointestinal Endoscopy. Gastrointest Endosc 1998; 48:663–668.
Utsunomiya J, Gocho H, Miyanaga T, Hamaguchi E, Kashimure A. Peutz-Jeghers syndrome: its natural course and management. Johns Hopkins Med J 1975; 136:71–82.
Konishi F, Wyse NE, Muto T, et al. Peutz-Jeghers polyposis associated with carcinoma of the digestive organs. Report of three cases and review of the literature. Dis Colon Rectum 1987; 30:790–799.
Perzin KH, Bridge MF. Adenomatous and carcinomatous changes in hamartomatous polyps of the small intestine (Peutz-Jeghers syndrome): report of a case and review of the literature. Cancer 1982; 49:971–983.
Defago MR, Higa AL, Campra JL, et al. Carcinoma in situ arising in a gastric hamartomatous polyp in a patient with Peutz-Jeghers syndrome. Endoscopy 1996; 28:267.
Linos DA, Dozois RR, Dahlin DC, Bartholomew LG. Does Peutz-Jeghers syndrome predispose to gastrointestinal malignancy? A later look. Arch Surg 1981; 116:1182–1184.
Spigelman AD, Murday V, Phillips RK. Cancer and the Peutz-Jeghers syndrome. Gut 1989; 30:1588–1590.
Giardiello FM, Welsh SB, Hamilton SR, et al. Increased risk of cancer in the Peutz-Jeghers syndrome. N Engl J Med 1987; 316:1511–1514.
Foley TR, McGarrity TJ, Abt AB. Peutz-Jeghers syndrome: a clinicopathologic survey of the “Harrisburg family” with a 49-year follow-up. Gastroenterology 1988; 95:1535–1540.
Dunlop MG, British Society for Gastroenterology. Association of Coloproctology for Great Britain and Ireland. Guidance on gastrointestinal surveillance for hereditary non-polyposis colorectal cancer, familial adenomatous polyposis, juvenile polyposis, and Peutz-Jeghers syndrome. Gut 2002; 51(Suppl 5):V21–V27.
Woodford-Richens K, Bevan S, Churchman M, et al. Analysis of genetic and phenotypic heterogeneity in juvenile polyposis. Gut 2000; 46:656–660.
Goodman ZD, Yardley JH, Milligan FD. Pathogenesis of colonic polyps in multiple juvenile polyposis: report of a case associated with gastric polyps and carcinoma of the rectum. Cancer 1979; 43:1906–1913.
Hizawa K, Iida M, Yao T, Aoyagi K, Fujishima M. Juvenile polyposis of the stomach: clinicopathological features and its malignant potential. J Clin Pathol 1997; 50:771–774.
Howe JR, Mitros FA, Summers RW. The risk of gastrointestinal carcinoma in familial juvenile polyposis. Ann Surg Oncol 1998:751–756.
Scott-Conner CE, Hausmann M., Hall TJ, Skelton DS. Anglin BL. Subramony C. Familial juvenile polyposis: patterns of recurrence and implications for surgical management. J Am Coll Surg 1995; 181:407–413.
Taylor AJ, Dodds WJ, Stewart ET. Alimentary tract lesions in Cowden’s disease. Br J Radiol 1989; 62:890–892.
Marra G, Armelao F, Vecchio FM, Percesepe A, Anti M. Cowden’s disease with extensive gastrointestinal polyposis. J Clin Gastroenterol 1994; 18:42–47.
Hizawa K, Iida M, Matsumoto T, et al. Gastrointestinal manifestations of Cowden’s disease. Report of four cases. J Clin Gastroenterol 1994; 18:13–18.
Chilovi F, Zancanella L, Perino F, et al. Cowden’s disease with gastrointestinal polyposis. Gastrointest Endosc 1990; 36:323,324.
Daniel ES, Ludwig SL, Lewin KJ, Ruprecht RM, Rajacich GM, Schwabe AD. The Cronkhite-Canada Syndrome. An analysis of clinical and pathologic features and therapy in 55 patients. Medicine 1982; 61:203–309.
Burke AP, Sobin LH. The pathology of Cronkhite-Canada polyps. A comparison to juvenile polyposis. Am J Surg Pathol 1989; 13:940–946.
Sagara K, Fujiyama S, Kamuro Y, Tashiro A, Sato T. Cronkhite-canada syndrome associated with gastric cancer: report of a case. Gastroenterol Jpn 1983; 18:260–266.
Watanabe T, Kudo M, Shirane H, et al. Cronkhite-Canada syndrome associated with triple gastric cancers: a case report. Gastrointest Endosc 1999; 50:688–691.
Seifert E, Elster K. Gastric polypectomy. Am J Gastroenterol 1975; 63:451–456.
Fabry TL, Frankel A, Waye JD. Gastric polyps. J Clin Gastroenterol 1982; 4:23–27.
Muehldorfer SM, Stolte M, Martus P, Hahn EG, Ell C. Multicenter Study Group “Gastric Polyps”. Diagnostic accuracy of forceps biopsy versus polypectomy for gastric polyps: a prospective multi-centre study. Gut 2002; 50:465–470.
ReMine SG, Hughes RW Jr, Weiland LH. Endoscopic gastric polypectomies. Mayo Clin Proc 1981; 56:371–375.
Gyrtrup HJ, Siemsen M, Vilmann P, Mogensen AM. Endoscopic ultrasonography in the evaluation of gastric polyps in juvenile polyposis. Endoscopy 1997; 29:136,137.
Tursi A, Brandimarte G. Endoscopic polypectomy of large pedunculated gastric polyps using a new, safe, and effective technique. Endoscopy 2002; 34:673,674.
Lo CC, Hsu PI, Lo GH, et al. Endoscopic banding ligation can effectively resect hyperplastic polyps of stomach. World J Gastroenterol 2003; 9:2805–2808.
Wahab P, Mulder CJ, den Hartog G, Thies JE. Argon plasma coagulation in flexible gastrointestinal endoscopy: pilot experiences. Endoscopy 1997; 29:176–181.
Kamiya T, Morishita T, Asakura H, Munakata Y, Miura S, Tsuchiya M. Histoclinical long-standing follow-up study of hyperplastic polyps of the stomach. Am J Gastroenterol 1981; 75: 275–281.
Cappell MS, Fiest TC. A multicenter, multiyear, case-controlled study of the risk of colonic polyps in patients with gastric polyps. Are gastric adenomas a new indication for surveillance colonoscopy? J Clin Gastroenterol 1995; 21:198–202.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Humana Press, Totowa, NJ
About this chapter
Cite this chapter
Makar, G.A., Ginsberg, G.G. (2006). Gastric Polyps. In: Faigel, D.O., Kochman, M.L. (eds) Endoscopic Oncology. Humana Press. https://doi.org/10.1007/978-1-59745-172-7_10
Download citation
DOI: https://doi.org/10.1007/978-1-59745-172-7_10
Publisher Name: Humana Press
Print ISBN: 978-1-58829-532-3
Online ISBN: 978-1-59745-172-7
eBook Packages: MedicineMedicine (R0)