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Electrical and Structural Remodeling in Atrial Fibrillation

The Role of Oxidant Stress and Systemic Inflammation

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Atrial Fibrillation

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

Intense research efforts since 1995 have sought to characterize the pathways that contribute to the occurrence and persistence of atrial fibrillation (AF). This chapter focuses on recent studies elucidating several of the molecular mechanisms that underlie the electrical and structural remodeling processes that promote persistent AF. Here there is a particular focus on the identification of signaling pathways that might be specifi cally and individually targeted for improved pharmacologic treatment or prevention of AF, perhaps simultaneously lowering the risk of stroke associated with AF.

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Acknowledgment

Supported by NIH RO1 HL65412 and the Atrial Fibrillation Innovation Center, an Ohio Wright Center Initiative.

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Authors and Affiliations

  1. Departments of Molecular Cardiology and Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH

    David R. Van Wagoner (Associate Staff, Associate Professor)

  2. Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH

    David R. Van Wagoner (Associate Staff, Associate Professor)

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  1. David R. Van Wagoner
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Editors and Affiliations

  1. Arrhythmia Institute, St. David's Medical Center, Austin, Texas, USA

    Andrea Natale MD (Executive Medical Director of the Texas Cardiac Arrhythmia Institute, Consulting Professor) (Executive Medical Director of the Texas Cardiac Arrhythmia Institute, Consulting Professor)

  2. Division of Cardiology, Stanford University, Palo Alto, CA, USA

    Andrea Natale MD (Executive Medical Director of the Texas Cardiac Arrhythmia Institute, Consulting Professor) (Executive Medical Director of the Texas Cardiac Arrhythmia Institute, Consulting Professor)

  3. University of Michigan, Ann Arbor, MI, USA

    José Jalife MD (Professor of Internal Medicine, The Cyrus and Jane Farrehi Professor of Cardiovascular Research, Professor of Molecular and Integrative Physiology) (Professor of Internal Medicine, The Cyrus and Jane Farrehi Professor of Cardiovascular Research, Professor of Molecular and Integrative Physiology)

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Wagoner, D.R. (2008). Electrical and Structural Remodeling in Atrial Fibrillation. In: Natale, A., Jalife, J. (eds) Atrial Fibrillation. Contemporary Cardiology. Humana Press. https://doi.org/10.1007/978-1-59745-163-5_5

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  • DOI: https://doi.org/10.1007/978-1-59745-163-5_5

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-856-0

  • Online ISBN: 978-1-59745-163-5

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