Myasthenia Gravis: Classification and Outcome Measurements

  • Gil I. Wolfe
  • Richard J. Barohn
Part of the Current Clinical Neurology book series (CCNEU)


Myasthenia gravis is the best characterized and understood autoimmune disease of the nervous system (1). It is the most common neuromuscular transmission disorder followed in neurology clinics. Nevertheless, standardized classification and grading systems and outcome measures for MG were not developed until the last decade and continue to be refined. In 1997 the Medical Scientific Advisory Board (MSAB) of the Myasthenia Gravis Foundation of America (MGFA) formed a task force to design classification and outcome measures for the disease (2). The task force’s primary charge was to create a system of uniformity in recording and reporting clinical data and outcomes research. Chairing the project was Dr. Alfred Jaretzki III, a cardiothoracic surgeon who had published extensively with colleagues at Columbia Presbyterian Medical Center on thymectomy for MG (3, 4). He expressed concern that published outcomes following thymectomy could not be reliably compared across studies due...


Amyotrophic Lateral Sclerosis Mycophenolate Mofetil Manual Muscle Testing Score Static Fatigue Testing Complete Stable Remission 
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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Gil I. Wolfe
    • 1
  • Richard J. Barohn
    • 2
  1. 1.Department of NeurologyUniversity of Texas Southwestern Medical SchoolDallas
  2. 2.Department of NeurologyUniversity of Kansas Medical CenterKansas City

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