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The Diabetic Kidney pp 419–436Cite as

Treatment in Advanced Renal Disease in Type 1 and Type 2 Diabetes

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Part of the book series: Contemporary Diabetes ((CDI))

Abstract

Not so long ago, terminal renal failure used to be a death sentence for the diabetic patient. In 1972, in a famous paper entitled “;The Sad Truth About Hemodialysis in Diabetic Nephropathy,”; Ghavamian arrived at the conclusion that “dialysis for such patients — carries little likelihood of long-term survival or improvement in quality of life” (1). Although survival of uremic diabetic patients has improved dramatically in recent years, such historical experience underlines the particular susceptibility of the diabetic patient to cardiovascular (CV) complications and infectious episodes.

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REFERENCES

  1. Ghavamian M, Gutch CF, Kopp KF, Kolff WJ. The sad truth about hemodialysis in diabetic nephropathy. JAMA 1972;222:1386–1389.

    Article  PubMed  CAS  Google Scholar 

  2. Lillehei RC, Simmons RL, Najarian JS, et al. Pancreatico-duodenal allotransplantation: experimental and clinical experience. Ann Surg 1970;172:405–436.

    Article  PubMed  CAS  Google Scholar 

  3. Becker BN, Brazy PC, Becker YT, et al. Simultaneous pancreas-kidney transplantation reduces excess mortality in type-1 diabetic patients with end-stage renal disease. Kidney Int 2000;57:2129–2135.

    Article  PubMed  CAS  Google Scholar 

  4. Van Biesen W, Vanholder RC, Veys N, Dhondt A, Lameire NH. An evaluation of an integrative care approach for end-stage renal disease patients. J Am Soc Nephrol 2000;11:116–125.

    PubMed  Google Scholar 

  5. Bojestig M, Arnqvist HJ, Hermansson G, Karlberg BE, Ludvigsson J. Declining incidence of nephropathy in insulin-dependent diabetes mellitus. N Engl J Med 1994;330:15–18.

    Article  PubMed  CAS  Google Scholar 

  6. Gaede P, Vedel P, Larsen N, Jensen GV, Parving HH, Pedersen O. Multifactorial intervention and cardiovascular disease in patients with type-2 diabetes. N Engl J Med 2003;348:383–393.

    Article  PubMed  Google Scholar 

  7. Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001;414:782–787.

    Article  PubMed  CAS  Google Scholar 

  8. Adler AI, Stevens RJ, Manley SE, Bilous RW, Cull CA, Holman RR. Development and progression of nephropathy in type-2 diabetes: the United Kingdom prospective diabetes study (UKPDS 64). Kidney Int 2003;63:225–232.

    Article  PubMed  Google Scholar 

  9. Yokoyama H, Okudaira M, Otani T, et al. Higher incidence of diabetic nephropathy in type 2 than in type 1 diabetes in early-onset diabetes in Japan. Kidney Int 2000;58:302–311.

    Article  PubMed  CAS  Google Scholar 

  10. Ritz E, Orth SR. Nephropathy in patients with type-2 diabetes mellitus. N Engl J Med 1999;341:1127–1133.

    Article  PubMed  CAS  Google Scholar 

  11. McBean AM, Li S, Gilbertson DT, Collins AJ. Differences in diabetes prevalence, incidence, and mortality among the elderly of four racial/ethnic groups: whites, blacks, hispanics, and asians. Diabetes Care 2004;27:2317–2324.

    Article  PubMed  Google Scholar 

  12. Stengel B, Billon S, Van Dijk PC, et al. Trends in the incidence of renal replacement therapy for end-stage renal disease in Europe, 1990-1999. Nephrol Dial Transplant 2003;18:1824–1833.

    Article  PubMed  Google Scholar 

  13. Ritz E, Stefanski A. Diabetic nephropathy in type II diabetes. Am J Kidney Dis 1996;27:167–194.

    PubMed  CAS  Google Scholar 

  14. Collins AJ, Kasiske B, Herzog C, et al. Excerpts from the United States renal data system 2003 annual data report: atlas of end-stage renal disease in the United States. Am J Kidney Dis 2003;42:A5–A7.

    Article  PubMed  Google Scholar 

  15. Schwenger V, Mussig C, Hergesell O, Zeier M, Ritz E. Incidence and clinical characteristics of renal insufficiency in diabetic patients. Dtsch Med Wochenschr 2001;126:1322–1326.

    Article  PubMed  CAS  Google Scholar 

  16. Koch M, Thomas B, Tschope W, Ritz E. Survival and predictors of death in dialysed diabetic patients. Diabetologia 1993;36:1113–1117.

    Article  PubMed  CAS  Google Scholar 

  17. Koch M, Kutkuhn B, Trenkwalder E, et al. Apolipoprotein B, fibrinogen, HDL cholesterol, and apolipoprotein(a) phenotypes predict coronary artery disease in hemodialysis patients. J Am Soc Nephrol 1997;8:1889–1898.

    PubMed  CAS  Google Scholar 

  18. Wanner C, Krane V, Ruf G, Marz W, Ritz E. Rationale and design of a trial improving outcome of type-2 diabetics on hemodialysis. Die Deutsche Diabetes Dialyse Studie Investigators. Kidney Int Suppl 1999;71:S222–S226.

    Article  PubMed  CAS  Google Scholar 

  19. Dikow R, Adamczak M, Henriquez DE, Ritz E. Strategies to decrease cardiovascular mortality in patients with end-stage renal disease. Kidney Int 2002;64:5–10.

    Article  Google Scholar 

  20. Dikow R, Ritz E. Cardiovascular complications in the diabetic patient with renal disease: an update in 2003. Nephrol Dial Transpl 2003;18:1993–1998.

    Article  Google Scholar 

  21. Iseki K, Tozawa M, Iseki C, Takishita S, Ogawa Y. Demographic trends in the Okinawa dialysis study (OKIDS registry 1971-2000. Kidney Int 2002;61:668–675.

    Article  PubMed  Google Scholar 

  22. Gilbertson DT XJL, Collins AJ. The increasing burden of diabetes in United States ESRD patients. J Am Soc Nephrol 13:646a, 2002.

    Google Scholar 

  23. Chantrel F, Enache I, Bouiller M, et al. Abysmal prognosis of patients with type-2 diabetes entering dialysis. Nephrol Dial Transpl 1999;14:129–136.

    Article  CAS  Google Scholar 

  24. Schwenger V, Hofmann A, Khalifeh N, et al. Uremic patients-late referral, early death. Dtsch Med Wochenschr 2003;128:1216–1220.

    Article  PubMed  CAS  Google Scholar 

  25. Stack AG, Bloembergen WE. A cross-sectional study of the prevalence and clinical correlates of congestive heart failure among incident US dialysis patients. Am J Kidney Dis 2001;38:992–1000.

    PubMed  CAS  Google Scholar 

  26. Levin A, Djurdjev O, Barrett B, et al. Cardiovascular disease in patients with chronic kidney disease: getting to the heart of the matter. Am J Kidney Dis 2001;38:1398–1407.

    PubMed  CAS  Google Scholar 

  27. Foley RN, Culleton BF, Parfrey PS, et al. Cardiac disease in diabetic end-stage renal disease. Diabetologia 1997;40:1307–1312.

    Article  PubMed  CAS  Google Scholar 

  28. Hypolite IO, Bucci J, Hshieh P, et al. Acute coronary syndromes after renal transplantation in patients with end-stage renal disease resulting from diabetes. Am J Transpl 2002;2:274–281.

    Article  Google Scholar 

  29. Herzog CA, Ma JZ, Collins AJ. Poor long-term survival after acute myocardial infarction among patients on long-term dialysis. N Engl J Med 1998;339:799–805.

    Article  PubMed  CAS  Google Scholar 

  30. Shlipak MG, Fried LF, Crump C, et al. Cardiovascular disease risk status in elderly persons with renal insufficiency. Kidney Int 2002;62:997–1004.

    Article  PubMed  Google Scholar 

  31. Foley RN, Parfrey PS, Sarnak MJ. Epidemiology of cardiovascular disease in chronic renal disease. J Am Soc Nephrol 1998;9:S16–S23.

    Article  PubMed  CAS  Google Scholar 

  32. Standl E, Schnell O. A new look at the heart in diabetes mellitus: from ailing to failing. Diabetologia 2000;43:1455–1469.

    Article  PubMed  CAS  Google Scholar 

  33. Amann K, Ritz E. Microvascular disease-the Cinderella of uraemic heart disease. Nephrol Dial Transplant 2000;15:1493–1503.

    Article  PubMed  CAS  Google Scholar 

  34. Aviles RJ, Askari AT, Lindahl B, et al. Troponin T levels in patients with acute coronary syndromes, with or without renal dysfunction. N Engl J Med 2002;346:2047–2052.

    Article  PubMed  CAS  Google Scholar 

  35. Mallamaci F, Zoccali C, Parlongo S, et al. Troponin is related to left ventricular mass and predicts all-cause and cardiovascular mortality in hemodialysis patients. Am J Kidney Dis 2002;40:68–75.

    Article  PubMed  CAS  Google Scholar 

  36. Manske CL, Wang Y, Rector T, Wilson RF, White CW. Coronary revascularisation in insulin-dependent diabetic patients with chronic renal failure. Lancet 1992;340:998–1002.

    Article  PubMed  CAS  Google Scholar 

  37. Herzog CA, Ma JZ, Collins AJ. Long-term outcome of dialysis patients in the United States with coronary revascularization procedures. Kidney Int 1999;56:324–332.

    Article  PubMed  CAS  Google Scholar 

  38. Herzog CA, Ma JZ, Collins AJ. Comparative survival of dialysis patients in the United States after coronary angioplasty, coronary artery stenting, and coronary artery bypass surgery and impact of diabetes. Circulation 2002;106:2207–2211.

    Article  PubMed  Google Scholar 

  39. Zuanetti G, Maggioni AP, Keane W, Ritz E. Nephrologists neglect administration of betablockers to dialysed diabetic patients. Nephrol Dial Transpl 1997;12:2497–2500.

    Article  CAS  Google Scholar 

  40. Cice G, Ferrara L, D’Andrea A, et al. Carvedilol increases two-year survivalin dialysis patients with dilated cardiomyopathy: a prospective, placebo-controlled trial. J Am Coll Cardiol 2003;41:1438–1444.

    Article  PubMed  CAS  Google Scholar 

  41. Tschope W, Koch M, Thomas B, Ritz E. Serum lipids predict cardiac death in diabetic patients on maintenance hemodialysis. Results of a prospective study. The German Study Group Diabetes and Uremia. Nephron 1993;64:354–358.

    Article  PubMed  CAS  Google Scholar 

  42. Liu Y, Coresh J, Eustace JA, et al. Association between cholesterol level and mortality in dialysis patients: role of inflammation and malnutrition. JAMA 2004;291:451–459.

    Article  PubMed  CAS  Google Scholar 

  43. Foley RN, Herzog CA, Collins AJ. Smoking and cardiovascular outcomes in dialysis patients: The United States Renal Data System Wave 2 Study. Kidney Int 2003;63:1462–1467.

    Article  PubMed  Google Scholar 

  44. Wu MS, Yu CC, Yang CW, et al. Poor pre-dialysis glycaemic control is a predictor of mortality in type II diabetic patients on maintenance haemodialysis. Nephrol Dial Transpl 1997;12:2105–2110.

    Article  CAS  Google Scholar 

  45. Morioka T, Emoto M, Tabata T, et al. Glycemic control is a predictor of survival for diabetic patients on hemodialysis. Diabetes Care 2001;24:909–913.

    Article  PubMed  CAS  Google Scholar 

  46. Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G. Effects of an angiotensin-convertingenzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med 2000;342:145–153.

    Article  PubMed  CAS  Google Scholar 

  47. Brenner BM, Cooper ME, de Zeeuw D, et al. Effects of losartan on renal and cardiovascular outcomes in patients with type-2 diabetes and nephropathy. N Engl J Med 2001;345:861–869.

    Article  PubMed  CAS  Google Scholar 

  48. Lewis EJ, Hunsicker LG, Bain RP, Rohde RD. The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group. N Engl J Med 1993;329:1456–1462.

    Article  PubMed  CAS  Google Scholar 

  49. Lewis EJ, Hunsicker LG, Clarke WR, et al. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type-2 diabetes. N Engl J Med 2001;345:851–860.

    Article  PubMed  CAS  Google Scholar 

  50. Palmer BF. Renal dysfunction complicating the treatment of hypertension. N Engl J Med 2002;347:1256–1261.

    Article  PubMed  Google Scholar 

  51. Wolf G, Ritz E. Diabetic nephropathy in type-2 diabetes prevention and patient management. J Am Soc Nephrol 2003;14:1396–1405.

    Article  PubMed  Google Scholar 

  52. Kalantar-Zadeh K, Block G, Humphreys MH, Kopple JD. Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients. Kidney Int 2003;63:793–808.

    Article  PubMed  Google Scholar 

  53. Bosman DR, Winkler AS, Marsden JT, Macdougall IC, Watkins PJ. Anemia with erythropoietin deficiency occurs early in diabetic nephropathy. Diabetes Care 2001;24:495–499.

    Article  PubMed  CAS  Google Scholar 

  54. Thomas MC, MacIsaac RJ, Tsalamandris C, et al. Anemia in patients with type-1 diabetes. J Clin Endocrinol Metab 2004;89:4359–4363.

    Article  PubMed  CAS  Google Scholar 

  55. Ishimura E, Nishizawa Y, Okuno S, et al. Diabetes mellitus increases the severity of anemia in non-dialyzed patients with renal failure. US J Nephrol 1998;11:83–86.

    CAS  Google Scholar 

  56. Dikow R, Schwenger V, Schomig M, Ritz E. How should we manage anaemia in patients with diabetes? Nephrol Dial Transpl 2002;171:67–72.

    Article  Google Scholar 

  57. Friedman EA, L’Esperance FA, Brown CD, Berman DH. Treating azotemia-induced anemia with erythropoietin improves diabetic eye disease. Kidney Int Suppl 2003;S57–S63.

    Google Scholar 

  58. Sinclair SH, DelVecchio C, Levin A. Treatment of anemia in the diabetic patient with retinopathy and kidney disease. Am J Ophthalmol 2003;135:740–743.

    Article  PubMed  Google Scholar 

  59. Hassan K, Simri W, Rubenchik I, et al. Effect of erythropoietin therapy on polyneuropathy in predialytic patients. J Nephrol 2003;16:121–125.

    PubMed  CAS  Google Scholar 

  60. Wakeen M, Zimmerman SW. Association between human recombinant EPO and peripheral vascular disease in diabetic patients receiving peritoneal dialysis. Am J Kidney Dis 1998;32:488–493.

    PubMed  CAS  Google Scholar 

  61. Spaia S, Pangalos M, Askepidis N, et al. Effect of short-term rHuEPO treatment on insulin resistance in haemodialysis patients. Nephron 2000;84:320–325.

    Article  PubMed  CAS  Google Scholar 

  62. Rigalleau V, Blanchetier V, Aparicio M, et al. Erythropoietin can deteriorate glucose control in uraemic non-insulin-dependent diabetic patients. Diabetes Metab 1998;24:62–65.

    PubMed  CAS  Google Scholar 

  63. Goldsmith D, Ritz E, Covic A. Vascular calcification: a stiff challenge for the nephrologist: does preventing bone disease cause arterial disease? Kidney Int 2004;66:1315–1333.

    Article  PubMed  Google Scholar 

  64. Procopio M, Borretta G. Derangement of glucose metabolism in hyperparathyroidism. J Endocrinol Invest 2003;26:1136–1142.

    PubMed  CAS  Google Scholar 

  65. Kuhlmann A, Haas CS, Gross ML, et al. 1,25-Dihydroxyvitamin D3 decreases podocyte loss and podocyte hypertrophy in the subtotally nephrectomized rat. Am J Physiol Renal Physiol 2004;286:F526–F533.

    Article  PubMed  CAS  Google Scholar 

  66. Block GA, Martin KJ, de Francisco AL, et al. Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis. US N Engl J Med 2004;350:1516–1525.

    Article  CAS  Google Scholar 

  67. Konner K, Nonnast-Daniel B, Ritz E. The arteriovenous fistula. J Am Soc Nephrol 2003;14:1669–1680.

    Article  PubMed  Google Scholar 

  68. Konner K. Primary vascular access in diabetic patients: an audit. Nephrol Dial Transpl 2000;15:1317–1325.

    Article  CAS  Google Scholar 

  69. Dixon BS, Novak L, Fangman J. Hemodialysis vascular access survival: upper-arm native arteriovenous fistula. Am J Kidney Dis 2002;39:92–101.

    PubMed  Google Scholar 

  70. Gefen JY, Fox D, Giangola G, Ewing DR, Meisels IS. The transposed forearm loop arteriovenous fistula: a valuable option for primary hemodialysis access in diabetic patients. Ann Vasc Surg 2002;16:89–94.

    Article  PubMed  Google Scholar 

  71. Yeager RA, Moneta GL, Edwards JM, et al. Relationship of hemodialysis access to finger gangrene in patients with end-stage renal disease. J Vasc Surg 2002;36:245–249; discussion 249.

    Article  PubMed  Google Scholar 

  72. Daugirdas JT. Pathophysiology of dialysis hypotension: an update. Am J Kidney Dis 2001;38:S11–S17.

    PubMed  CAS  Google Scholar 

  73. Karnik JA, Young BS, Lew NL, et al. Cardiac arrest and sudden death in dialysis units. Kidney Int 2001;60:350–357.

    Article  PubMed  CAS  Google Scholar 

  74. Joy MS, Cefalu WT, Hogan SL, Nachman PH. Long-term glycemic control measurements in diabetic patients receiving hemodialysis. Am J Kidney Dis 2002;39:297–307.

    PubMed  Google Scholar 

  75. Ritz E, Koch M. Morbidity and mortality due to hypertension in patients with renal failure. Am J Kidney Dis 1993;21:113–118.

    PubMed  CAS  Google Scholar 

  76. Malmberg K, Norhammar A, Ryden L. Insulin treatment post myocardial infarction: the DIGAMI study. Adv Exp Med Biol 2001;498:279–284.

    PubMed  CAS  Google Scholar 

  77. van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med 2001;345:1359–1367.

    Article  PubMed  Google Scholar 

  78. Okuno S, Ishimura E, Kim M, et al. Changes in body fat mass in male hemodialysis patients: a comparison between diabetics and nondiabetics. Am J Kidney Dis 2001;38:S208–S211.

    PubMed  CAS  Google Scholar 

  79. Saraheimo M, Teppo AM, Forsblom C, Fagerudd J, Groop PH. Diabetic nephropathy is associated with low-grade inflammation in Type-1 diabetic patients. Diabetologia 2003;46:1402–1407.

    Article  PubMed  CAS  Google Scholar 

  80. Suliman ME, Stenvinkel P, Heimburger O, Barany P, Lindholm B, Bergstrom J. Plasma sulfur amino acids in relation to cardiovascular disease, nutritional status, and diabetes mellitus in patients with chronic renal failure at start of dialysis therapy. Am J Kidney Dis 2002;40:480–488.

    Article  PubMed  CAS  Google Scholar 

  81. Cano NJ, Roth H, Aparicio M, et al. Malnutrition in hemodialysis diabetic patients: evaluation and prognostic influence. Kidney Int 2002;62:593–601.

    Article  PubMed  Google Scholar 

  82. Sehgal AR, Leon JB, Siminoff LA, Singer ME, Bunosky LM, Cebul RD. Improving the quality of hemodialysis treatment: a community-based randomized controlled trial to overcome patient-specific barriers. JAMA 2002;287:1961–1967.

    Article  PubMed  Google Scholar 

  83. Heaf JG, Lokkegaard H, Madsen M. Initial survival advantage of peritoneal dialysis relative to haemodialysis. Nephrol Dial Transpl 2002;17:112–117.

    Article  Google Scholar 

  84. Winkelmayer WC, Glynn RJ, Mittleman MA, Levin R, Pliskin JS, Avorn J. Comparing mortality of elderly patients on hemodialysis versus peritoneal dialysis: a propensity score approach. J Am Soc Nephrol 2002;13:2353–2362.

    Article  PubMed  Google Scholar 

  85. Suzuki H, Kanno Y, Sugahara S, Okada H, Nakamoto H. Effects of an angiotensin II receptor blocker, valsartan, on residual renal function in patients on CAPD. Am J Kidney Dis 2004;43:1056–1064.

    Article  PubMed  CAS  Google Scholar 

  86. Nevalainen PI, Lahtela JT, Mustonen J, Pasternack A. Subcutaneous and intraperitoneal insulin therapy in diabetic patients on CAPD. Perit Dial Int 1996;161:S288–S2291.

    Google Scholar 

  87. Wolfe RA, Ashby VB, Milford EL, et al. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med 1999;341:1725–1730.

    Article  PubMed  CAS  Google Scholar 

  88. Mieghem AV, Fonck C, Coosemans W, et al. Outcome of cadaver kidney transplantation in 23 patients with type-2 diabetes mellitus. Nephrol Dial Transpl 2001;16:1686–1691.

    Article  CAS  Google Scholar 

  89. Manske CL, Thomas W, Wang Y, Wilson RF. Screening diabetic transplant candidates for coronary artery disease: identification of a low risk subgroup. Kidney Int 1993;44:617–621.

    Article  PubMed  CAS  Google Scholar 

  90. Kelly WD, Lillehei RC, Merkel FK, Idezuki Y, Goetz FC. Allotransplantation of the pancreas and duodenum along with the kidney in diabetic nephropathy. Surgery 1967;61:827–837.

    PubMed  CAS  Google Scholar 

  91. Tyden G, Bolinder J, Solders G, Brattstrom C, Tibell A, Groth CG. Improved survival in patients with insulin-dependent diabetes mellitus and end-stage diabetic nephropathy 10 years after combined pancreas and kidney transplantation. Transplantation 1999;67:645–648.

    Article  PubMed  CAS  Google Scholar 

  92. Solders G, Tyden G, Tibell A, Persson A, Groth CG. Improvement in nerve conduction 8 years after combined pancreatic and renal transplantation. Transplant Proc 1995;27:3091.

    Google Scholar 

  93. Hathaway DK, Abell T, Cardoso S, Hartwig MS, el Gebely S, Gaber AO. Improvement in autonomic and gastric function following pancreas-kidney versus kidney-alone transplantation and the correlation with quality of life. Transplantation 1994;57:816–822.

    Article  PubMed  CAS  Google Scholar 

  94. Kahl A, Bechstein WO, Frei U. Trends and perspectives in pancreas and simultaneous pancreas and kidney transplantation. Curr Opin Urol 2001;11:165–174.

    Article  PubMed  CAS  Google Scholar 

  95. Hariharan S, Pirsch JD, Lu CY, et al. Pancreas after kidney transplantation. J Am Soc Nephrol 2002;13:1109–1118.

    PubMed  Google Scholar 

  96. Rooney DP, Robertson RP. Hepatic insulin resistance after pancreas transplantation in type-I diabetes. Diabetes 1996;45:134–138.

    Article  PubMed  CAS  Google Scholar 

  97. Tyden G, Reinholt FP, Sundkvist G, Bolinder J. Recurrence of autoimmune diabetes mellitus in recipients of cadaveric pancreatic grafts. N Engl J Med 1996;335:860–863.

    Article  PubMed  CAS  Google Scholar 

  98. Luzi L, Perseghin G, Brendel MD, et al. Metabolic effects of restoring partial beta-cell function after islet allotransplantation in type 1 diabetic patients. Diabetes 2001;50:277–282.

    Article  PubMed  CAS  Google Scholar 

  99. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type-1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000;343:230–238.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, Ruperto Carola University, Heidelberg, Germany

    Eberhard Ritz MD

  2. Zentrum Innere Medizin, Medizinische Klinik IV, Universitätsklinikum Hamburg—Eppendorf, Hamburg, Germany

    Gunter Wolf MD

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  1. Eberhard Ritz MD
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Editors and Affiliations

  1. Division of Nephrology and Hypertension, Department of Medicine, Henry Ford Hospital, Detroit, MI

    Pedro Cortes MD

  2. Department of Internal Medicine M (Diabetes and Endocrinology), Aarhus University Hospital, Aarhus, Denmark

    Carl Erik Mogensen MD

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© 2006 Humana Press Inc., Totowa, NJ

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Ritz, E., Wolf, G. (2006). Treatment in Advanced Renal Disease in Type 1 and Type 2 Diabetes. In: Cortes, P., Mogensen, C.E. (eds) The Diabetic Kidney. Contemporary Diabetes. Humana Press. https://doi.org/10.1007/978-1-59745-153-6_24

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