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The Prospect of a Novel Therapeutic, Bone Morphogenetic Protein-7, in Diabetic Nephropathy

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Book cover The Diabetic Kidney

Part of the book series: Contemporary Diabetes ((CDI))

Abstract

We are in the midst of a worldwide epidemic of diabetes and hypertension. In the United States, the overall incidence of end-stage kidney disease (ESKD) is increasing at an alarming rate due to this epidemic. Recently, the incidence of ESKD was estimated at 336 per million per year (1), such that the number of patients with ESKD may approach 2.24 million by 2030. Moreover, approx 11% of the population is estimated to have chronic kidney disease (CKD), with nearly half the patients with a glomerular filtration rate (GFR) less than 60 mL/min/1.73 m2 (2). Similar estimates for other countries have been described in Europe (3), Japan (4), and Australia (5). The most common form of CKD in all of these countries is diabetic nephropathy (DN), accounting for approx 40% of the new cases of ESKD in developed countries.

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Author information

Authors and Affiliations

  1. Department of Pediatrics, Washington University School of Medicine, St. Louis, MO

    Keith A. Hruska MD

  2. Departments of Pediatrics and Internal Medicine, Washington University School of Medicine, St. Louis, MO

    Laura Petris MD

  3. Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO

    Tingting Li MD

  4. Third Hospital of Beijing Medical University, Beijing, China

    Song Wang MD

  5. Department of Pediatrics, Washington University School of Medicine, St. Louis, MO

    Theresa Geurs BS & Frank Strebeck BS

  6. Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO

    Qing Chen

  7. Department of Pathology, Washington University, St. Louis, MO

    Helen Liapis MD

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  1. Keith A. Hruska MD
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  2. Laura Petris MD
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  4. Song Wang MD
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  5. Theresa Geurs BS
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  7. Qing Chen
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  8. Helen Liapis MD
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Editors and Affiliations

  1. Division of Nephrology and Hypertension, Department of Medicine, Henry Ford Hospital, Detroit, MI

    Pedro Cortes MD

  2. Department of Internal Medicine M (Diabetes and Endocrinology), Aarhus University Hospital, Aarhus, Denmark

    Carl Erik Mogensen MD

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© 2006 Humana Press Inc., Totowa, NJ

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Hruska, K.A. et al. (2006). The Prospect of a Novel Therapeutic, Bone Morphogenetic Protein-7, in Diabetic Nephropathy. In: Cortes, P., Mogensen, C.E. (eds) The Diabetic Kidney. Contemporary Diabetes. Humana Press. https://doi.org/10.1007/978-1-59745-153-6_18

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  • DOI: https://doi.org/10.1007/978-1-59745-153-6_18

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-624-5

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