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Genomics of Helicobacter Species

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Bacterial Genomes and Infectious Diseases

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Abstract

Helicobacter pylori was the first bacterial species to have the genome of two independent strains completely sequenced. Infection with this pathogen, which may be the most frequent bacterial infection of humanity, causes peptic ulcer disease and gastric cancer. Other Helicobacter species are emerging as causes of infection, inflammation, and cancer in the intestine, liver, and biliary tract, although the true prevalence of these enterohepatic Helicobacter species in humans is not yet known. The murine pathogen Helicobacter hepaticus was the first enterohepatic Helicobacter species to have its genome completely sequenced. Here, we consider functional genomics of the genus Helicobacter, the comparative genomics of the genus Helicobacter, and the related genera Campylobacter and Wolinella.

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Author information

Authors and Affiliations

  1. Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA

    Zhongming Ge

  2. Division of Comparative Medicine and Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA

    David B. Schauer

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  1. Zhongming Ge
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  2. David B. Schauer
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Editors and Affiliations

  1. Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada

    Voon L. Chan PhD

  2. Department of Paediatrics Department of Laboratory Medicine and Pathobiology Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

    Philip M. Sherman MD, FRCPC

  3. Children’s Research Center, Our Lady’s Hospital for Sick Children, School of Medicine and Medical Science, Dublin, Ireland

    Billy Bourke MD, FRCPI

  4. Conway Institute for Biomolecular and Biomedical Research, University College, Dublin, Ireland

    Billy Bourke MD, FRCPI

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© 2006 Humana Press Inc., Totowa, NJ

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Ge, Z., Schauer, D.B. (2006). Genomics of Helicobacter Species. In: Chan, V.L., Sherman, P.M., Bourke, B. (eds) Bacterial Genomes and Infectious Diseases. Humana Press. https://doi.org/10.1007/978-1-59745-152-9_6

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  • DOI: https://doi.org/10.1007/978-1-59745-152-9_6

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-496-8

  • Online ISBN: 978-1-59745-152-9

  • eBook Packages: MedicineMedicine (R0)

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