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Bacterial Genomes and Infectious Diseases pp 63–90Cite as

Campylobacter

From Glycome to Pathogenesis

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Abstract

Genome sequencing of Campylobacter jejuni NCTC11168 identified an abundance of carbohydrate biosynthetic clusters comprising a large proportion of the genome. Many of these pathways were already under investigation including the lipooligosaccharide, flagellar O-linked protein glycosylation, and general N-linked protein glycosylation systems. Genome sequencing also identified a novel cluster of genes, which was subsequently shown to be involved in capsular polysaccharide biosynthesis. In order to fully understand the C. jejuni glycome, sophisticated analytical techniques were employed for functional characterization. We will describe these four important carbohydrate pathways highlighting the methods used to characterize these systems, the biological relevance the sugars play in campylobacter survival and pathogenesis, and the potential exploitation of the glycome for novel therapeutics against this common food-borne pathogen.

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Author information

Authors and Affiliations

  1. Institute for Biological Sciences, National Research Council, Ottawa, Ontario, Canada

    John Kelly, Jean-Robert Brisson, N. Martin Young, Harold C. Jarrell & Christine M. Szymanski

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  1. John Kelly
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  2. Jean-Robert Brisson
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  4. Harold C. Jarrell
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  5. Christine M. Szymanski
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Editors and Affiliations

  1. Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada

    Voon L. Chan PhD

  2. Department of Paediatrics Department of Laboratory Medicine and Pathobiology Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

    Philip M. Sherman MD, FRCPC

  3. Children’s Research Center, Our Lady’s Hospital for Sick Children, School of Medicine and Medical Science, Dublin, Ireland

    Billy Bourke MD, FRCPI

  4. Conway Institute for Biomolecular and Biomedical Research, University College, Dublin, Ireland

    Billy Bourke MD, FRCPI

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© 2006 Humana Press Inc., Totowa, NJ

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Kelly, J., Brisson, JR., Young, N.M., Jarrell, H.C., Szymanski, C.M. (2006). Campylobacter. In: Chan, V.L., Sherman, P.M., Bourke, B. (eds) Bacterial Genomes and Infectious Diseases. Humana Press. https://doi.org/10.1007/978-1-59745-152-9_5

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  • DOI: https://doi.org/10.1007/978-1-59745-152-9_5

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