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Troxacitabine (Troxatyl ™)

A Deoxycytidine Nucleoside Analog With Potent Antitumor Activity
  • Henriette Gourdeau
  • Jacques Jolivet
Part of the Cancer Drug Discovery and Development book series (CDD&D)

Abstract

Nucleoside analogs are commonly used in the treatment of hematological malignancies and solid tumors. As antimetabolites, these drugs act by disrupting DNA synthesis and inducing apoptosis following their incorporation into DNA. Troxacitabine (Troxatyl™ Shire Biochem, Inc., exclusively licensed to SGX Pharmaceuticals, Inc.) is the first nucleoside analog with anticancer activity that has an unnatural stereochemical configuration. Its broad preclinical antineoplastic spectrum led to its clinical development. Summaries of the preclinical data and of the initial phase I and II clinical trials are presented.

Key Words

Chemotherapy clinical treatment hematological malignancies solid tumors troxacitabine 

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Copyright information

© Humana Press Inc., Totowa, NJ 2006

Authors and Affiliations

  • Henriette Gourdeau
    • 1
  • Jacques Jolivet
    • 2
  1. 1.Pharmacology/ToxicologyEcopia BioSciences Inc.Ville Saint-LaurentCanada
  2. 2.Aegera Therapeutics Inc.MontrealCanada

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