Abstract
Restless legs syndrome (RLS) is a sensorimotor disorder that affects sleep in up to 15% of the population. Individuals experience uncomfortable sensations of the extremities, which occur with inactivity and are relieved with activity. Because of the circadian rhythmicity of these symptoms, RLS symptoms can interfere with sleep onset. Symptom descriptors are varied; some commonly used terms are “creepy-crawly,” “uncomfortable,” “pins and needles,” and “internal itch.” Regardless of the descriptor, symptoms of RLS include a compelling urge to move, as they are usually improved with movement, and patients frequently resort to flexing, stretching, and vigorous movement. The end result is typically poor quality of sleep, leading to excessive daytime somnolence and feelings of fatigue. Althugh the disorder affects both genders, it is more common in women (in most populations studied) and is associated with several medical conditions including uremia, anemia, diabetes, pregnancy, and menopause.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ekbom K., Restless legs: a clinical study. Ada Med Scand Suppl, 1945;158:1–123.
Walters A.S., Toward a better definition of the restless legs syndrome. The International Restless Legs Syndrome Study Group. Mov Disord, 1995;10(5):634–642.
Montplaisir J., M. Michaud, R. Denesle, and A. Gosselin, Periodic leg movements are not more prevalent in insomnia or hypersomnia but are specifically associated with sleep disorders involving a dopaminergic impairment. Sleep Med, 2000;l(2):163–167.
Dorsey CM., S.E. Lukas, and S.L. Cunningham, Fluoxetine-induced sleep disturbance in depressed patients. Neuropsychopharmacology, 1996;14(6):437–442.
Nofzinger E.A., A. Fasiczka, S. Berman, and M.E. Thase, Bupropion SR reduces periodic limb movements associated with arousals from sleep in depressed patients with periodic limb movement disorder. J Clin Psychiatry, 2000;61(11):858–862.
Fantini M.L., M. Michaud, N. Gosselin, G. Lavigne, and J. Montplaisir, Periodic leg movements in REM sleep behavior disorder and related autonomic and EEG activation. Neurology, 2002;59(12):1889–1894.
Exar E.N. and N.A. Collop, The association of upper airway resistance with periodic limb movements. Sleep, 2001;24(2):188–192.
Baran A.S., A.C. Richert, A.B. Douglass, W. May, and K. Ansarin, Change in periodic limb movement index during treatment of obstructive sleep apnea with continuous positive airway pressure. Sleep, 2003;26(6):717–720.
Phillips B., T. Young, L. Finn, K. Asher, W.A. Hening, and C. Purvis, Epidemiology of restless legs symptoms in adults. Arch Intern Med, 2000;60(14):2137–2141.
Nichols D.A., R.P. Allen, J.H. Grauke, et al., Restless legs syndrome symptoms in primary care: a prevalence study. Arch Intern Med, 2003;63(19):2323–2329.
Berger K, J. Luedemann, C. Trenkwalder, U. John, and C. Kessler, Sex and the risk of restless legs syndrome in the general population. Arch Intern Med, 2004;164(2):196–202.
Kutner N.G. and D.L. Bliwise, Restless legs complaint in African-American and Caucasian hemodialysis patients. Sleep Med, 2002;3(6):497–500.
Tan E.K., A. Seah, S.J. See, E. Lim, M.C. Wong, and K.K. Koh, Restless legs syndrome in an Asian population: a study in Singapore. Mov Disord, 2001;16(3):577–579.
Kageyama T, M. Kabuto H. Nitta, et al., Prevalences of periodic limb movement-like and restless legs-like symptoms among Japanese adults. Psychiatry Clin Neurosci, 2000;4(3):296–298.
Bhowmik D., M. Bhatia, S. Gupta, S.K. Agarwal, S.C. Tiwari, and S.C. Dash, Restless legs syndrome in hemodialysis patients in India: a case controlled study. Sleep Med, 2003;4(2):143–146.
Rajaram S.S., A.S. Walters, S.J. England, D. Mehta, and F. Nizam, Some children with growing pains may actually have restless legs syndrome. Sleep, 2004;27(4):767–773.
Walters A.S., D.L. Picchietti, B.L. Ehrenberg, and M.L. Wagner, Restless legs syndrome in childhood and adolescence. Pediatr Neurol, 1994;11(3):241–245.
Hening W., R. Allen, C. Earley, C. Kushida, D. Icchietti, and M. Silber, The treatment of restless legs syndrome and periodic limb movement disorder. An American Academy of Sleep Medicine Review. Sleep, 1999;22(7):970–999.
Ekbom K.A., Restless legs syndrome. Neurology, 1960;10:868–873.
O’Keeffe S.T., K. Gavin, and J.N. Lavan, Iron status and restless legs syndrome in the elderly. Age Ageing, 1994;23(3):200–203.
Sun E.R., C.A. Chen, G. Ho, C.J. Earley, and R.P. Allen, Iron and the restless legs syndrome. Sleep, 1998;21(4):371–377.
Allen R.P., P.B. Barker, F. Wehrl, H.K. Song, and C.J. Earley, MRI measurement of brain iron in patients with restless legs syndrome. Neurology, 2001;56(2):263–265.
Tarquini B., Iron metabolism: clinical chroniological aspects. Chronobiologia, 1978;5:315–336.
Ruottinen H.M., M. Partinen, C. Hublin, et al., An FDOPA PET study in patients with periodic limb movement disorder and restless legs syndrome. Neurology, 2000;54(2):502–504.
Turjanski N., A.J. Lees, and D.J. Brooks, Striatal dopaminergic function in restless legs syndrome: 18F-dopa and 11 C-raclopride PET studies. Neurology, 1999;52(5):932–937.
Eisensehr I., T.C. Wetter, R. Linke, et al., Normal IPT and IBZM SPECT in drug-naive and levodopa-treated idiopathic restless legs syndrome. Neurology, 2001;57(7):1307–1309.
Michaud M., M. Dumont, B. Selmaoui, J. Paquet, M.L. Fantini, and J. Montplaisir, Circadian rhythm of restless legs syndrome: relationship with biological markers. Ann Neurol, 2004;55(3):372–380.
Kunz D., and F. Bes, Exogenous melatonin in periodic limb movement disorder: an open clinical trial and a hypothesis. Sleep, 2001;24(2):183–187.
Tribl G.G., F. Waldhauser, T. Sycha, E. Auff, and J. Zeitlhofer, Urinary 6-hydroxy-melatonin-sulfate excretion and circadian rhythm in patients with restless legs syndrome. J Pineal Res, 2003;35(4):295–296.
Ondo W. and J. Jankovic, Restless legs syndrome: clinicoetiologic correlates. Neurology, 1996;47(6):1435–1441.
Walters A.S., K. Hickey, J. Maltzman, et al., A questionnaire study of 138 patients with restless legs syndrome: the ‘Night-Walkers’ survey. Neurology, 1996;46(l):92–95.
Winkelmann J., T.C. Wetter, V. Collado-Seidel, et al., Clinical characteristics and frequency of the hereditary restless legs syndrome in a population of 300 patients. Sleep, 2000;23(5):597–602.
Bassetti C.L., D. Mauerhofer, M. Gugger, J. Mathis, and C.W. Hess, Restless legs syndrome: a clinical study of 55 patients. Eur Neurol, 2001;45(2):67–74.
Desai A.V., L.F. Cherkas, T.D. Spector, and A.J. Williams, Genetic influences in self-reported symptoms of obstructive sleep apnoea and restless legs: a twin study. Twin Res, 2004;7(6):589–595.
Ondo W.G., K.D. Vuong, and Q. Wang, Restless legs syndrome in monozygotic twins: clinical correlates. Neurology, 2000;55(9):1404–1406.
Desautels A., G. Turecki, J. Montplaisir, A. Sequeira, A. Vemer, and G.A. Rouleau, Identification of a major susceptibility locus for restless legs syndrome on chromosome 12q. Am J Hum Genet, 2001;69(6):1266–1270.
Bonati M.T., L. Ferini-Strambi, P. Aridon, A. Oldani, M. Zucconi, and G. Casari, Autosomal dominant restless legs syndrome maps on chromosome 14q. Brain, 2003;126(Pt 6):1485–1492.
Paulson G.W. Restless legs syndrome. How to provide symptom relief with drug and nondrug therapies. Geriatrics, 2000;55(4):35–47.
Trenkwalder C, D. Garcia-Borreguero, P. Montagna, et al., Ropinirole in the treatment of restless legs syndrome: results from the TREAT RLS 1 study, a 12 week, randomised, placebo controlled study in 10 European countries. JNeurol Neurosurg Psychiatry, 2004;75(l):92–97.
Adler C.H., R.A. Hauser, K. Seth, et al., Ropinirole for restless legs syndrome: a placebo-controlled crossover trial. Neurology, 2004;62(8):1405–1407.
Lin S.C., J. Kaplan, CD. Burger, and P.A. Fredrickson, Effect of pramipexole in treatment of resistant restless legs syndrome. Mayo Clin Proc, 1998;73(6):497–500.
Becker P.M., W. Ondo, and D. Sharon, Encouraging initial response of restless legs syndrome to pramipexole. Neurology, 1998;51(4):1221–1223.
Montplaisir J., R. Denesle, and D. Petit, Pramipexole in the treatment of restless legs syndrome: a follow-up study. Eur J Neurol, 2000;7(Suppl 1):27–31.
Winkelman J.W. and L. Johnston, Augmentation and tolerance with long-term pramipexole treatment of restless legs syndrome (RLS). Sleep Med, 2004;5(l):9–14.
Walters A.S., J. Winkelmann, C. Trenkwalder, et al., Long-term follow-up on restless legs syndrome patients treated with opioids. Mov Disord, 2001;16(6):1105–1109.
Garcia-Borreguero D., O. Larrosa, de la LY, K. Verger, X. Masramon, and G. Hernandez, Treatment of restless legs syndrome with gabapentin: a double-blind, cross-over study. Neurology, 2002;59(10):1573–1579.
Lee K.A., M.E. Zaffke, and K. Baratte-Beebe, Restless legs syndrome and sleep disturbance during pregnancy: the role of folate and iron. J Womens Health Gend Based Med, 2001;10(4):335–341.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Humana Press Inc., Totowa, NJ
About this chapter
Cite this chapter
Hiestand, D.M., Phillips, B. (2006). Restless Legs Syndrome. In: Attarian, H.P. (eds) Sleep Disorders in Women. Current Clinical Neurology. Humana Press. https://doi.org/10.1007/978-1-59745-115-4_8
Download citation
DOI: https://doi.org/10.1007/978-1-59745-115-4_8
Publisher Name: Humana Press
Print ISBN: 978-1-58829-592-7
Online ISBN: 978-1-59745-115-4
eBook Packages: MedicineMedicine (R0)