Multifocal Motor Neuropathy

  • Michael Benatar


Multifocal motor neuropathy (MMN) is a relatively recently recognized clinical entity that was formally described by Parry and Clark in the mid-1980s (1,2). The clinical presentation in each of the patients in this original series had suggested a diagnosis of motor neuron disease, but nerve conduction studies showed multifocal conduction block in motor nerves. The recognition that this syndrome represented a form of a chronic demyelinating neuropathy has spawned much debate regarding its relationship to other chronic demyelinating neuropathies such as chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and the Lewis-Sumner syndrome, and has also raised the possibility that patients with the disorder might respond to immunosuppressive therapy. What are the clinical and electrophysiological features of MMN, and how does it differ from other chronic demyelinating neuropathies? What is the diagnostic accuracy of anti GM1 antibodies? Do patients with MMN respond to immunosuppressive therapy, and what is the long term prognosis for patients with this disorder? These and other questions are the focus of this chapter.


Nerve Conduction Study Conduction Block Multifocal Motor Neuropathy Chronic Inflammatory Demyelinating Polyradiculoneuropathy Progressive Muscular Atrophy 
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Copyright information

© Humana Press Inc., Totowa, NJ 2006

Authors and Affiliations

  • Michael Benatar
    • 1
  1. 1.Department of NeurologyEmory University School of MedicineAtlanta

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