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A Multimarker Approach to Evaluation of Patients With Acute Coronary Syndrome

  • Chapter
Cardiovascular Biomarkers

Part of the book series: Contemporary Cardiology ((CONCARD))

Abstract

The clinical application of biomarkers in patients with acute ischemic heart disease has evolved substantially. No longer is their use limited to the diagnosis of myocardial necrosis. Cardiac biomarkers may now be used as convenient and noninvasive tools to gain insight into the underlying causes and consequences of acute coronary syndrome (ACS) that mediate the risk of recurrent events and may be targets for therapeutic interventions. The emergence of novel biomarkers of inflammation, thrombosis, and hemodynamic stress have made possible an expanded role of multiple biomarkers, some old, others new, in the classification of patients with ACS. As proof of principle, a simple multimarker strategy using cardiac troponin, B-type natriuretic peptide, and C-reactive protein has been shown to enhance risk assessment. More work is needed to define the appropriate therapeutic responses to elevation of these novel markers. Moreover, as the understanding of the pathogenesis of ACS advances and new markers and therapies are discovered, the potential of multimarker strategies to add to present tools for clinical decision making and risk stratification will continue to evolve. This chapter describes the genesis and initial evaluation of the multimarker paradigm.

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Authors and Affiliations

  1. Cardiovascular Division, Department of Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA

    David A. Morrow MD, MPH (Assistant Professor of Medicine)

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  1. David A. Morrow MD, MPH
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Editors and Affiliations

  1. Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

    David A. Morrow MD, MPH

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© 2006 Humana Press Inc., Totowa, NJ

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Morrow, D.A. (2006). A Multimarker Approach to Evaluation of Patients With Acute Coronary Syndrome. In: Morrow, D.A. (eds) Cardiovascular Biomarkers. Contemporary Cardiology. Humana Press. https://doi.org/10.1007/978-1-59745-051-5_31

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  • DOI: https://doi.org/10.1007/978-1-59745-051-5_31

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-526-2

  • Online ISBN: 978-1-59745-051-5

  • eBook Packages: MedicineMedicine (R0)

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