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Cardiovascular Biomarkers pp 467–485Cite as

Measures of Platelet Activation and Aggregation

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Part of the book series: Contemporary Cardiology ((CONCARD))

Abstract

Platelets play a key role in the pathophysiology of cardiovascular disease. Disrupting platelet activation and aggregation with antiplatelet agents is effective both for primary and secondary prevention of atherothrombotic events, and has become a cornerstone of cardiovascular disease management nowadays. Identifying hyperactive platelets as predictors of a thrombotic tendency and monitoring the response to antiplatelet agents have become the key objectives of platelet function monitoring. We have learned more about the variable response to antiplatelet drugs as more accurate and reliable platelet function assays have been developed. However, there are currently no data establishing a cause-and-effect relationship or allowing for the establishment of an algorithm for treatment in response to measured platelet function inhibition.

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Author information

Authors and Affiliations

  1. Institut de Cardiologie, Hôpital Pitié-Salpêtriére, Paris, France

    Jean-Philippe Collet MD, PhD (Doctor) & Gilles Montalescot MD, PhD (Professor of Medicine)

Authors
  1. Jean-Philippe Collet MD, PhD
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  2. Gilles Montalescot MD, PhD
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Editors and Affiliations

  1. Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

    David A. Morrow MD, MPH

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© 2006 Humana Press Inc., Totowa, NJ

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Collet, JP., Montalescot, G. (2006). Measures of Platelet Activation and Aggregation. In: Morrow, D.A. (eds) Cardiovascular Biomarkers. Contemporary Cardiology. Humana Press. https://doi.org/10.1007/978-1-59745-051-5_27

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  • DOI: https://doi.org/10.1007/978-1-59745-051-5_27

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-526-2

  • Online ISBN: 978-1-59745-051-5

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