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C-Reactive Protein as a Tool for Risk Assessment in Primary Prevention

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Cardiovascular Biomarkers

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

High-sensitivity C-reactive protein (hsCRP) is a marker of inflammation that predicts incident myocardial infarction, stroke, peripheral arterial disease, and sudden cardiac death among healthy persons without a history of cardiovascular disease, as well as recurrent events and death in patients with acute or stable coronary syndromes. hsCRP adds prognostic value at all levels of low-density lipoprotein cholesterol, Framingham coronary risk score, severity of the metabolic syndrome, and blood pressure, and in those with and without subclinical atherosclerosis. Among apparently healthy men and women, hsCRP levels of less than 1, 1 to 3, and greater than 3 mg/L distinguish those at low, moderate, and high risk for future cardiovascular disease, respectively. In clinical settings, hsCRP should be used in conjunction with lipid evaluation as part of global risk assessment. Improved knowledge of cardiovascular risk should lead to better compliance with lifestyle and pharmacological interventions designed to prevent future cardiovascular events.

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Authors and Affiliations

  1. Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

    Shari S. Bassuk ScD (Epidemiologist)

  2. Division of Cardiovascular Disease Prevention, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

    Paul M. Ridker MD, MPH (Eugene Braunwald Professor of Medicine, Director)

  3. Center for Cardiovascular Disease Prevention, Donald W. Reynolds Center for Cardiovascular Research, Boston, MA

    Paul M. Ridker MD, MPH (Eugene Braunwald Professor of Medicine, Director)

Authors
  1. Shari S. Bassuk ScD
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  2. Paul M. Ridker MD, MPH
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Editors and Affiliations

  1. Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

    David A. Morrow MD, MPH

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© 2006 Humana Press Inc., Totowa, NJ

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Bassuk, S.S., Ridker, P.M. (2006). C-Reactive Protein as a Tool for Risk Assessment in Primary Prevention. In: Morrow, D.A. (eds) Cardiovascular Biomarkers. Contemporary Cardiology. Humana Press. https://doi.org/10.1007/978-1-59745-051-5_16

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  • DOI: https://doi.org/10.1007/978-1-59745-051-5_16

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-526-2

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