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Analytic Issues for Clinical Use of C-Reactive Protein

  • Nader Rifai
Part of the Contemporary Cardiology book series (CONCARD)

Abstract

The serum concentration of C-reactive protein (CRP) has historically been used to detect active infection and inflammation. Recent evidence has demonstrated that slight increases in CRP concentration, within the normal range, can predict future vascular events, thus reflecting the inflammatory component of atherosclerosis. It was necessary to develop new high-sensitivity methods for this clinical application, and to establish cut points for risk assessment of cardiovascular risk. To avoid misclassification of individuals into inappropriate categories of risk, clinicians and investigators must have an understanding of preanalytic and analytic sources of errors in CRP measurement. This chapter addresses issues that contribute to the reliability of CRP evaluation such as physiological variability, appropriate sample handling, and method standardizations.

Key Words

C-reactive protein measurement standardization interpretation 

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Copyright information

© Humana Press Inc., Totowa, NJ 2006

Authors and Affiliations

  • Nader Rifai
    • 1
    • 2
  1. 1.Children’s HospitalBoston
  2. 2.Harvard Medical SchoolBoston

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