Abstract
Centromeres are required for normal chromosome segregation in mitosis and meiosis, and a substantial proportion of human pathology stems from abnormalities of chromosome segregation, the underlying genomic basis and mechanism(s) of which are largely unknown. Human centromeres consist of megabases ofα-satelliteDNA, atandemlyrepeatedDNA family whose genomic organization, evolution, and function is increasingly well understood. The study of normal, abnormal, and engineered human chromosomes is providing insights into the nature of human centromeres and their mechanism of action, as well as enabling comparison with centromeres of other eukaryotic organisms and the identification of genomic elements required for normal centromere function.
Keywords
- Centromere Protein
- Centromere Function
- Human Artificial Chromosome
- Functional Centromere
- Human Centromere
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Willard, H.E., Rudd, M.K. (2006). Genomic Organization and Function of Human Centromeres. In: Lupski, J.R., Stankiewicz, P. (eds) Genomic Disorders. Humana Press. https://doi.org/10.1007/978-1-59745-039-3_8
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DOI: https://doi.org/10.1007/978-1-59745-039-3_8
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