Abstract
The centromere repositioning phenomenon consists in the move of the centromere along the chromosome during evolution. This phenomenon is relatively frequent, and has been documented in primates, nonprimate mammals, and birds. It implies the inactivation of the old centromere and the rapid progression of the newly seeded centromere toward the complex organization that probably stabilizes its activity. Both events have a huge impact on chromosomal architecture. The segmental duplicon clusters at 6p22.1 and 15q24-26 are clear examples of remains of inactivated ancestral centromeres. These duplicons are dispersed in a relatively large area (approx 10 Mb), and contribute to the bulk of nonpericentromeric segmental duplications that constitute approx 5% of the human genome.
Keywords
- Bacterial Artificial Chromosome
- Bacterial Artificial Chromosome Clone
- Segmental Duplication
- Radiation Hybrid
- Common Marmoset
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© 2006 Humana Press Inc., Totowa, NJ
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Rocchi, M., Archidiacono, N. (2006). Genome Plasticity in Evolution. In: Lupski, J.R., Stankiewicz, P. (eds) Genomic Disorders. Humana Press. https://doi.org/10.1007/978-1-59745-039-3_10
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DOI: https://doi.org/10.1007/978-1-59745-039-3_10
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