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Vasculogenesis and Angiogenesis

  • Chapter
The Cell Cycle in the Central Nervous System

Part of the book series: Contemporary Neuroscience ((CNEURO))

Abstract

Vasculogenesis, angiogenesis, and arteriogenesis are terms used to describe the formation of blood vessels. Embryonic neovascularization by vasculogenesis refers to the formation of primitive blood vessels inside the embryo and its surrounding membranes and involves the in situ differentiation of mesoderm-derived angioblasts, which aggregate and form de novo blood vessels. Vascularization of the brain occurs primarily through angiogenesis. Angiogenesis involves the formation of new blood vessels via sprouting or splitting from pre-existing vessels and occurs both pre- and postnatally. Arteriogenesis refers to the enlargement of pre-existing collateral arterioles to form larger arteries. Specific angiogenic factor signaling systems choreograph each step of blood vessel formation. Vasculogenesis and angiogenesis are not exclusive processes but instead constitute complementary mechanisms for postnatal neovascularization.

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Author information

Authors and Affiliations

  1. Wilford Hall Medical Center, Lackland Air Force Base, TX

    Gerald A. Grant MD (Director of Pediatric Neurosurgery)

  2. Cerebrovascular Research Laboratory, Department of Neurosurgery, The Cleveland Clinic Foundation, Cleveland, OH

    Damir Janigro PhD

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  1. Gerald A. Grant MD
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  2. Damir Janigro PhD
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Editors and Affiliations

  1. The Cleveland Clinic Foundation, Cleveland, OH

    Damir Janigro PhD

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© 2006 Humana Press Inc., Totowa, NJ

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Grant, G.A., Janigro, D. (2006). Vasculogenesis and Angiogenesis. In: Janigro, D. (eds) The Cell Cycle in the Central Nervous System. Contemporary Neuroscience. Humana Press. https://doi.org/10.1007/978-1-59745-021-8_4

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