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The Contribution of Bone Marrow-Derived Cells to Cerebrovascular Formation and Integrity

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The Cell Cycle in the Central Nervous System

Part of the book series: Contemporary Neuroscience ((CNEURO))

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Abstract

The contribution of bone marrow-derived circulating cells to the formation and maintenance of the vasculature, and the cerebrovasculature in particular, has been established. It is becoming evident that several different populations of cells including early progenitor-like cells, monocytic cells, and perhaps mesenchymal stem cells are responsible for the reported actions of “endothelial progenitor cells.” Large variation in the relative contribution of bone marrow-derived cells to formation and repair of the vasculature in different experimental systems illustrates some of the factors that influence the behavior of bone marrow-derived cells.

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Authors and Affiliations

  1. Department of Radiology, University of Washington School of Medicine, Seattle, WA

    David Kobiler PhD

  2. The Cancer Institute of New Jersey, New Brunswick, NJ

    John Glod MD, PhD

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  1. David Kobiler PhD
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  2. John Glod MD, PhD
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  1. The Cleveland Clinic Foundation, Cleveland, OH

    Damir Janigro PhD

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Kobiler, D., Glod, J. (2006). The Contribution of Bone Marrow-Derived Cells to Cerebrovascular Formation and Integrity. In: Janigro, D. (eds) The Cell Cycle in the Central Nervous System. Contemporary Neuroscience. Humana Press. https://doi.org/10.1007/978-1-59745-021-8_17

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