The Origins and Characteristics of Asthma
Asthma has become a common medical problem in the United States, especially among blacks.
Wheezing is a frequently encountered pediatric problem. When wheezing is recurrent, asthma is an important consideration.
Risk factors for pediatric asthma are strongly associated with genetics (parental) and being atopic.
Adult-onset asthma is more common in females, but other risk factors, as seen in children, are not as strongly associative.
Asthma many relapse after years of quiescence.
Asthma is characterized by bronchoconstriction, bronchial hyperresponsiveness, βadrenergic blockade, and inflammation.
Pulmonary eosinophilia is a common feature of asthma.
Increased exhaled nitric oxide is a marker of inflammation.
Specific T-cell cytokines are unique to asthma, including interleukin (IL)-4, IL-5, and IL-13.
IL-13 may play an important role in asthma pathogenesis.
KeywordsNitric Oxide Allergic Rhinitis Airway Smooth Muscle Allergy Clin Immunol Behavioral Risk Factor Surveillance System
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