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The Origins and Characteristics of Asthma

  • Russell J. Hopp
  • Robert G. Townley
Part of the Current Clinical Practice book series (CCP)

Abstract

  • Asthma has become a common medical problem in the United States, especially among blacks.

  • Wheezing is a frequently encountered pediatric problem. When wheezing is recurrent, asthma is an important consideration.

  • Risk factors for pediatric asthma are strongly associated with genetics (parental) and being atopic.

  • Adult-onset asthma is more common in females, but other risk factors, as seen in children, are not as strongly associative.

  • Asthma many relapse after years of quiescence.

  • Asthma is characterized by bronchoconstriction, bronchial hyperresponsiveness, βadrenergic blockade, and inflammation.

  • Pulmonary eosinophilia is a common feature of asthma.

  • Increased exhaled nitric oxide is a marker of inflammation.

  • Specific T-cell cytokines are unique to asthma, including interleukin (IL)-4, IL-5, and IL-13.

  • IL-13 may play an important role in asthma pathogenesis.

Keywords

Nitric Oxide Allergic Rhinitis Airway Smooth Muscle Allergy Clin Immunol Behavioral Risk Factor Surveillance System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Humana Press Inc. 2006

Authors and Affiliations

  • Russell J. Hopp
    • 1
  • Robert G. Townley
    • 2
  1. 1.Department of Pediatrics and MedicineUniversity of Utah School of MedicineSalt Lake City
  2. 2.Department of PediatricsCreighton University School of MedicineOmaha

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