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Pathological Anatomy of Restenosis

  • Chapter
Essentials of Restenosis

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

Until recently, in-stent restenosis remained the “Achilles Heal” for interventional cardiologists. The introduction of drug-eluting stents (DES) [CYPHER, Cordis J&J, NJ (sirolimus) and TAXUS, Boston Scientific Corp. Boston (paclitaxel)] however, has made a tremendous impact on rates of in-stent restenosis with dramatic reductions fro 30 to 40% in bare metal stent to 0 to 9% with DES ((1)–(4)).The compelling results from large clinical trial with DES stents involve mostly simple lesion morphologies with follow-up of only 6–12 mo; it is still unclear whether a sustained benefit will be reached in more complex lesions and high-risk patients such as diabetics (5). In this review, the stages of healing in response to bare metal stents implants in animals and humans will be discussed as a bases for understanding the localized effects of polymers and/or drugs on these natural biological processes.

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Author information

Authors and Affiliations

  1. Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC

    Renu Virmani MD & Frank D. Kolodgie PhD

  2. Cardiac Unit, Department of Internal Medicine, Massachusetts General Hospital, Boston, MA

    Aloke V. Finn MD & Herman K. Gold MD

Authors
  1. Renu Virmani MD
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  2. Frank D. Kolodgie PhD
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  3. Aloke V. Finn MD
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  4. Herman K. Gold MD
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Editor information

Editors and Affiliations

  1. Thoraxcenter, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands

    Henricus J. Duckers MD, PhD  & Patrick W. Serruys MD, PhD  & 

  2. The Nabel Lab, Genome Technology Branch, NHGRI Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD

    Elizabeth G. Nabel MD

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© 2007 Humana Press Inc.

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Virmani, R., Kolodgie, F.D., Finn, A.V., Gold, H.K. (2007). Pathological Anatomy of Restenosis. In: Duckers, H.J., Nabel, E.G., Serruys, P.W. (eds) Essentials of Restenosis. Contemporary Cardiology. Humana Press. https://doi.org/10.1007/978-1-59745-001-0_4

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  • DOI: https://doi.org/10.1007/978-1-59745-001-0_4

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-491-3

  • Online ISBN: 978-1-59745-001-0

  • eBook Packages: MedicineMedicine (R0)

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