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Fatty Acids, Cell Signaling, and Cardiovascular Risk

  • Chapter
Hypertension and Hormone Mechanisms

Part of the book series: Contemporary Endocrinology ((COE))

Abstract

Abdominal obesity is linked to increased non-esterified fatty acid (NEFA) concentrations and turnover that are resistant to suppression by insulin (1,2). Similarly, physical activity and maximal oxygen consumption, a marker of physical fitness, are inversely associated with plasma NEFA concentrations measured as the area under-the-curve during a standard 2-h oral glucose tolerance test (3). Familial combined hyperlipidemia, a relatively common autosomal dominant trait, is associated with high plasma NEFAs as well as greater and more prolonged elevation of NEFAs following a fat load (4). Obesity, sedentary lifestyles, and familial combined hyperlipidemia are associated with high blood pressure, abnormal glucose and lipid metabolism, and more cardiovascular events including sudden death (5–7).

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  1. Department of General Internal Medicine and Hypertension, Medical University of South Carolina, Charleston, SC

    Brent M. Egan MD

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  1. Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA

    Robert M. Carey MD, MACP (David A. Harrison III Distinguished Professor of Medicine) (David A. Harrison III Distinguished Professor of Medicine)

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Egan, B.M. (2007). Fatty Acids, Cell Signaling, and Cardiovascular Risk. In: Carey, R.M. (eds) Hypertension and Hormone Mechanisms. Contemporary Endocrinology. Humana Press. https://doi.org/10.1007/978-1-59259-987-5_12

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  • DOI: https://doi.org/10.1007/978-1-59259-987-5_12

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