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The Intrarenal Renin-Angiotensin System

  • Chapter
Hypertension and Hormone Mechanisms

Part of the book series: Contemporary Endocrinology ((COE))

Abstract

We enter a new phase in our understanding of the intrarenal renin-angiotensin system (RAS) in which its intriguing complexities are appreciated. Indeed, it is apparent that the RAS with its multiple components operates in autocrine and intracrine manners as well as an endocrine system. The new developments have raised our awareness of distinct regulatory mechanisms for the intratubular and intracellular as well as the interstitial RAS in the kidney. In this chapter, we will briefly review the current understanding of the intrarenal RAS and discuss how its inappropriate activation alters the capability of the kidney to maintain an adequate sodium and fluid balance at normal arterial pressures, thus setting the stage for the development of hypertension.

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Authors and Affiliations

  1. Section of Diabetes, Hypertension, and Metabolism, Department of Medicine, University of Arizona, Tucson, AZ

    Minolfa C. Prieto-Carrasquero MD, PhD

  2. Departments of Physiology and Medicine, Molecular Core in Hypertension and Renal COE, Tulane University Health Sciences Center, New Orleans, LA

    Hiroyuki Kobori MD, PhD

  3. Department of Physiology, Tulane University Health Sciences Center, New Orleans, LA

    L. Gabriel Navar PhD

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  1. Minolfa C. Prieto-Carrasquero MD, PhD
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  2. Hiroyuki Kobori MD, PhD
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  3. L. Gabriel Navar PhD
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Editors and Affiliations

  1. Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA

    Robert M. Carey MD, MACP (David A. Harrison III Distinguished Professor of Medicine) (David A. Harrison III Distinguished Professor of Medicine)

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Prieto-Carrasquero, M.C., Kobori, H., Navar, L.G. (2007). The Intrarenal Renin-Angiotensin System. In: Carey, R.M. (eds) Hypertension and Hormone Mechanisms. Contemporary Endocrinology. Humana Press. https://doi.org/10.1007/978-1-59259-987-5_1

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