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Nutritional Amblyopia and B Complex Vitamin Deficiencies

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Handbook of Nutrition and Ophthalmology

Part of the book series: Nutrition and Health ((NH))

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Abstract

Nutritional amblyopia is defined as retrobulbar optic neuropathy with bilateral visual loss, central or cecocentral scotomas, and dyschromatopsia due to dietary deficiency. The condition is generally reversible if treated with proper diet and vitamins within 2 or 3 mo of onset of visual loss, but the prognosis for visual recovery is worse with longstanding disease and atrophy of the papillomacular bundle. Associated findings may include skin, mucosal, neurological, gastrointestinal, and hematological signs and symptoms characteristic of specific or mixed B vitamin deficiencies involving thiamin, niacin, folate, vitamin B12 and/or riboflavin. Riboflavin deficiency has been linked with cataract.

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References

  1. Strachan H. Malarial multiple peripheral neuritis. Annu Univ Med Sci 1888;1:139–141.

    Google Scholar 

  2. Strachan H. On a form of multiple neuritis prevalent in the West Indies. The Practitioner (London) 1897;51:477–484.

    Google Scholar 

  3. Shimazono J. I. B-Avitaminosis und Beriberi. Mit Bemerkungen zur alimentären Anämie, Veränderung der Nervensubstanz durch Aufbrauch und zur zentralen Wirkung der Schilddrüsensubstanz usw. Ergebnisse der inneren Medizin und Kinderheilkunde 1931;39:1–68.

    Google Scholar 

  4. Hori M. Über Augenerkrankungen bei Kakke. Tokyo Igakkai Zasshi 1888;5:4–27.

    Google Scholar 

  5. Kono T. Über das Auftreten der centralen Sehschwäche im Verlaufe von Kakke. Tokyo Igakkai Zasshi 1896;10:255–262.

    Google Scholar 

  6. Komoto J. [On the ophthalmological symptoms in the patient suffering from kakke.] Tokyo Iji Shinsi 1898;1030:1–5.

    Google Scholar 

  7. Lowther AH. Ocular disturbances associated with malnutrition. General discussion. Trans Ophthalmol Soc UK 1946;66:104–107.

    Google Scholar 

  8. Ridley H. Ocular disturbances associated with malnutrition. Trans Ophthalmol Soc UK 1946;66:45–71.

    Google Scholar 

  9. Centers for Disease Control. Epidemic neuropathy—Cuba, 1991–1994. MMWR Morb Mortal Wkly Rep 1994;43:183, 189–192.

    Google Scholar 

  10. Carpenter KJ. Beriberi, White Rice, and Vitamin B: A Disease, a Cause, and a Cure. Berkeley, University of California Press, 2000.

    Google Scholar 

  11. Bondt, J de. De medicina Indorum. Lugdoni Batavorum, F. Hackium, 1642.

    Google Scholar 

  12. Takaki B. Three lectures on the preservation of health amongst personnel of the Japanese Navy and Army. Lancet 1906;1:1369–1374(lecture 1), 1451–1455 (lecture 2).

    Google Scholar 

  13. Eijkman C. Polyneuritis bij hoenders. Geneesk Tijdschr Nederl Indië 1890;30:295.

    Google Scholar 

  14. Eijkman C. Polyneuritis bij hoenders. Geneesk Tijdschr Nederl Indië 1893;32:353.

    Google Scholar 

  15. Eijkman C. Polyneuritis bij hoenders. Geneesk Tijdschr Nederl Indië 1896;36:214.

    Google Scholar 

  16. Fletcher W. Rice and beri-beri: preliminary report on an experiment conducted at the Kuala Lumpur Lunatic Asylum. Lancet 1907;1:1776–1779.

    Google Scholar 

  17. Fletcher W. Rice and beri-beri. J Trop Med Hyg 1909;12:127–135.

    CAS  Google Scholar 

  18. Vorderman AG. Onderzoek naar het verband tusschen den aard der rijstvoeding in de gevangenissen op Java en Madoera en het voorkomen van beri-beri onder de geïnterneerden. Batavia, Jav. Boekh. & Drukkerij, 1897.

    Google Scholar 

  19. Strong RF, Crowell BC. The etiology of beriberi. Phil J Sci 1912;7(B):271–411.

    Google Scholar 

  20. Fraser H, Stanton AT. An inquiry concerning the etiology of beriberi. Studies from the Institute for Medical Research, No. 10, 1909.

    Google Scholar 

  21. Funk C. On the chemical nature of the substance which cures polyneuritis in birds induced by a diet of polished rice. J Physiol 1911;43:395–400.

    CAS  Google Scholar 

  22. Suzuki U, Shimamura T, Odake S. Über Oryzanin, ein Bestandteil der Reiskleie und seine physiologische Bedeutung. Biochemische Zeitschrift 1912;43:89–153.

    CAS  Google Scholar 

  23. Jansen BCP, Donath WF. Antineuritische Vitamine. Chem Weekbl 1926;23:1387–1409.

    Google Scholar 

  24. Williams RR, Cline JK. Synthesis of vitamin B1. J Am Chem Soc 1936;58:1504–1505.

    CAS  Google Scholar 

  25. Wilder RM, Williams RR. Enrichment of Flour and Bread: A History of the Movement. Bulletin of the National Research Council No. 110. Washington, D.C., National Academy of Sciences, 1944.

    Google Scholar 

  26. Ma JJ, Truswell AS. Wernicke-Korsakoff syndrome in Sydney hospitals: before and after thiamine enrichment of flour. Med J Aust 1995;163:531–534.

    CAS  Google Scholar 

  27. Harper CG, Sheedy DL, Lara AI, Garrick TM, Hilton JM, Raisanen J. Prevalence of Wernicke-Korsakoff syndrome in Australia: has thiamine fortification made a difference? Med J Aust 1998;168:542–545.

    CAS  Google Scholar 

  28. Vedder EB. Beriberi. New York, William Wood and Company, 1913.

    Google Scholar 

  29. Williams RR. Toward the Conquest of Beriberi. Cambridge, Harvard University Press, 1961.

    Google Scholar 

  30. Shimazono N, Katsura E. Review of Japanese Literature on Beriberi and Thiamine. Tokyo, Vitamin B Research Committee of Japan, 1965.

    Google Scholar 

  31. Rindi G, de Giuseppi L. The content of thiamine and its mono-, di-and triphosphoric esters in different biological materials. Int Z Vitamin Forsch 1961;31:321–326.

    CAS  Google Scholar 

  32. U. S. Department of Agriculture National Nutrient Database for Standard Reference (http://www.nal. usda.gov/fnic/foodcomp/search)

    Google Scholar 

  33. Gregory JF III. Bioavailability of thiamin. Eur J Clin Nutr 1997;51(suppl 1):S34–S37.

    Google Scholar 

  34. Rindi G, Ferrari G. Thiamine transport by human intestine in vitro. Experientia 1977;33:211–213.

    CAS  Google Scholar 

  35. Rindi G, Laforenza U. Thiamine intestinal transport and related issues: recent aspects. Proc Soc Exp Biol Med 2000;224:246–255.

    CAS  Google Scholar 

  36. Friedemann TE, Kmieciak TC, Keegan PK, Sheft BB. The absorption, destruction, and excretion of orally administered thiamin by human subjects. Gastroenterology 1948;11:100–114.

    CAS  Google Scholar 

  37. Morrison AB, Campbell JA. Vitamin absorption studies. I. Factors influencing the excretion of oral tst doses of thiamine and riboflavin by human subjects. J Nutr 1960;72:435–440.

    CAS  Google Scholar 

  38. Thomson AD, Leevy CM. Observations on the mechanism of thiamine hydrochloride absorption in man. Clin Sci 1972;43:153–163.

    CAS  Google Scholar 

  39. Picciano MF. Vitamins in milk. A. Water-soluble vitamins in human milk. In: Jensen RG (ed). Handbook of Milk Composition. San Diego, Academic: 1995; pp. 675–688.

    Google Scholar 

  40. Howard L, Wagner C, Schenker S. Malabsorption of thiamin in folate-deficient rats. J Nutr 1974;104:1024–1032.

    CAS  Google Scholar 

  41. Thomson AD, Baker H, Leevy CM. Patterns of 35S-thiamine hydrochloride absorption in the malnourished alcoholic patient. J Lab Clin Med 1970;76:34–45.

    CAS  Google Scholar 

  42. Tanphaichitr V. Thiamine. In: Rucker RB, Suttie JW, McCormick DB, Machlin LJ (eds). Handbook of Vitamins. Third edition. New York and Basel, Marcel Dekker: 2001; pp. 275–316.

    Google Scholar 

  43. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. A report of the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline, and Subcommittee on Upper Reference Levels of Nutrients. Washington, D.C., National Academy Press, 1998.

    Google Scholar 

  44. Elmadfa I, Majchrzak D, Rust P, Genser D. The thiamine status of adult humans depends on carbohydrate intake. Int J Vitam Nutr Res 2001;71:217–221.

    CAS  Google Scholar 

  45. Manore MM. Effect of physical activity on thiamine, riboflavin, and vitamin B-6 requirements. Am J Clin Nutr 2000;72(suppl):598S–606S.

    CAS  Google Scholar 

  46. Scheube B. Die Beriberi-Krankheit: Eine geographisch-medicinische Studie. Jena, Gustav Fischer, 1894.

    Google Scholar 

  47. Suter PM, Vetter W. Diuretics and vitamin B1: are diuretics a risk factor for thiamin malnutrition? Nutr Rev 2000;58:319–323.

    CAS  Google Scholar 

  48. Iber FL, Blass JP, Brin M, Leevy CM. Thiamin in the elderly—B relation to alcoholism and to neurological degenerative disease. Am J Clin Nutr 1982;36:1067–1082.

    CAS  Google Scholar 

  49. Vir SC, Love AHG. Thiamine status of institutionalised and non-institutionalised aged. Int J Vitam Nutr Res 1977;47:325–335.

    CAS  Google Scholar 

  50. Vir SC, Love AHG. Nutritional status of institutionalized and noninstitutionalized aged in Belfast, Northern Ireland. Am J Clin Nutt 1979;32:1934–1847.

    CAS  Google Scholar 

  51. Hoorn RKJ, Flikweert JP, Westerink D. Vitamin B-1, B-2, and B-6 deficiencies in geriatric patients, measured by coenzyme stimulation of enzyme activities. Clin Chim Acta 1975;61:151–162.

    CAS  Google Scholar 

  52. Boldorini R, Vago L, Lechi A, Tedeschi F, Trabattoni GR. Wernickeís encephalopathy: occurrence and pathological aspects in a series of 400 AIDS patients. Acta Biomed Atheneo Parmense 1992;63:43–49.

    CAS  Google Scholar 

  53. Sauberlich HE. Laboratory Tests for the Assessment of Nutritional Status. Second edition. Boca Raton, CRC Press, 1999.

    Google Scholar 

  54. Kawai C, Wakabayashi A, Matsumura T, Yui Y. Reappearance of beriberi heart disease in Japan. A study of 23 cases. Am J Med 1980;69:383–386.

    CAS  Google Scholar 

  55. Inouye K, Katsura E. Clinical signs and metabolism of beriberi patients. In: Shimazono N, Katsura E. Review of Japanese Literature on Beriberi and Thiamine. Tokyo, Vitamin B Research Committee of Japan: 1965; pp. 29–63.

    Google Scholar 

  56. Yamamoto Y. Über Centraskotom bei Kakke. Ophthalmol Klinik (Stuttgart) 1903;7:119.

    Google Scholar 

  57. Aoki T. Über Centralskotom bei Kakke (Beriberi). Ophthalmol Klinik (Stuttgart) 1903;7:118.

    Google Scholar 

  58. Tarissan. Le béribéri au Brésil. Faculté de Médecine de Paris, Thèse No. 110. Paris, A. Parent, 1881.

    Google Scholar 

  59. Fernando AS. The eye in beri-beri. Am J Ophthalmol 1923;6:385–388.

    Google Scholar 

  60. P’an C. Retrobulbar neuritis among the Chinese: a preliminary report. Chin Med J 1934;48:999–1004.

    Google Scholar 

  61. P’an C, Ling WP. Further observations on retrobulbar neuritis in the Chinese. Chin Med J 1936;50:1373–1380.

    Google Scholar 

  62. Lin CK. Retrobulbar neuritis among the Chinese: report of 53 cases. Chin Med J 1936;50:1345–1372.

    Google Scholar 

  63. Soriano FJ, Puiggari MI. Neuritis retro bulbar beriberica. Archivos de Oftalmología de Buenos Aires 1938;13:244–250.

    Google Scholar 

  64. Little JM. Beriberi. J Am Med Assoc 1914;63:1287–1290.

    Google Scholar 

  65. Little JM. Beriberi caused by fine white flour. J Am Med Assoc 1912;58:2029–2030.

    Google Scholar 

  66. Aykroyd WR. Beriberi and other food-deficiency diseases in Newfoundland and Labrador. J Hygiene 1930;30:357–386.

    CAS  Google Scholar 

  67. Kagawa S. Studies on the relationship of neuritis axialis to beriberi in Japan (first report). Jpn J Med Sci 1938;5:1–16.

    CAS  Google Scholar 

  68. Kageshima S. [On the anatomical change of eyes, especially of the optic nerves in beriberi.] Acta Soc Ophthal Jpn 1918;22:1069.

    Google Scholar 

  69. Hagedoorn A. Defizienz-Neuritis. Klin Monatsbl Augenh 1939;102:726.

    Google Scholar 

  70. Victor M, Adams RD, Collins GH. The Wernicke-Korsakoff syndrome and related neurologic disorders due to alcoholism and malnutrition. Second edition. Philadelphia, F. A. Davis Company, 1989.

    Google Scholar 

  71. Victor M, Mancall EL, Dreyfus PM. Deficiency amblyopia in the alcoholic patient. A clinicopathologic study. Arch Ophthalmol 1960;64:1–33.

    CAS  Google Scholar 

  72. Victor M, Dreyfus PM. Tobacco-alcohol amblyopia: further comments on its pathology. Arch Ophthalmol 1965;74:649–657.

    CAS  Google Scholar 

  73. Leigh D. Subacute necrotizing encephalomyelopathy in an infant. J Neurol Neurosurg Psychiatry 1951;14:216–221.

    CAS  Google Scholar 

  74. Kretzschmar HA, DeArmond SJ, Koch TK, et al. Pyruvate dehydrogenase complex deficiency as a cause of subacute necrotizing encephalopathy (Leigh disease). Pediatrics 1987;79:370–373.

    CAS  Google Scholar 

  75. Willems JL, Monnens LAH, Trijbels JMF, et al. Leigh’s encephalomyelopathy in a patient with cytochrome c oxidase deficiency in muscle tissue. Pediatrics 1977;60:850–857.

    CAS  Google Scholar 

  76. Van Erven PMM, Gabreëls FJM, Ruitenbeek W, Renier WO, Fischer JC. Mitochondrial encephalomyopathy: association with an NADH dehydrogenase deficiency. Arch Neurol 1987;44:775–778.

    Google Scholar 

  77. Howard RO, Albert DM. Ocular manifestations of subacute necrotizing encephalomyelopathy (Leigh’s disease). Am J Ophthalmol 1972;74:386–392.

    CAS  Google Scholar 

  78. Hayashi N, Geraghty MT, Green WR. Ocular histopathologic study of a patient with the T 8993-G point mutation in Leigh’s syndrome. Ophthalmology 2000;107:1397–1402.

    CAS  Google Scholar 

  79. Pastoris O, Savasta S, Foppa P, Catapano M, Dossena M. Pyruvate dehydrogenase deficiency in a child responsive to thiamine treatment. Acta Paediatr 1996;85:625–628.

    CAS  Google Scholar 

  80. Di Rocco M, Lamba LD, Minniti G, Caruso U, Naito E. Outcome of thiamine treatment in a child with Leigh disease due to thiamine-responsive pyruvate dehydrogenase deficiency. Eur J Paediatr Neurol 2000;4:115–117.

    Google Scholar 

  81. Carelli V, Sadun AA. Optic neuropathy in Lhon and Leigh syndrome. Ophthalmology 2001;108:1172–1173.

    CAS  Google Scholar 

  82. Barletta V. Chiasma e nervi ottici nel beri-beri sperimentale del colombo. (Richerche isto-patologiche). Rass Ital Ott 1932;1:210–227.

    Google Scholar 

  83. Marchesini E, Papagno M. Contributo clinico ed anatomo-patologigo alle manifestazioni oculari nel beri-beri aviario sperimentale. Ann Ottal Clin Ocul 1935;63:81–97.

    Google Scholar 

  84. Swank RL, Prados M. Avian thiamine deficiency. II. Pathologic changes in the brain and cranial nerves (especially the vestibular) and their relation to the clinical behavior. Arch Neurol Psychiat 1942;47:97–131.

    CAS  Google Scholar 

  85. Chick H, Peters RA, Carter CW, et al. Discussion on avitaminosis (B group) in tropical and temperate countries. Proc Roy Soc Med 1933–1934;27:473–487.

    Google Scholar 

  86. McDermott W, Webster B, Baker R, Lockhart J, Tompsett R. Nutritional degeneration of the optic nerve in rats: its relation to tryparsamide amblyopia. J Pharmacol 1943;77:24–39.

    CAS  Google Scholar 

  87. Prickett CO. The effect of a deficiency of vitamin B1 upon the central and peripheral nervous systems of the rat. Am J Physiol 1934;107:459–470.

    CAS  Google Scholar 

  88. Leinfelder PJ, Robbie WA. Experimental studies in retrobulbar neuritis. Am J Ophthalmol 1947;30:1135–1143.

    Google Scholar 

  89. Rodger FC. Experimental thiamin deficiency as a cause of degeneration in the visual pathway of the rat. Br J Ophthalmol 1953;37:11–29.

    CAS  Google Scholar 

  90. Lee J, Sure B. Avitaminosis. XIX. Nerve degeneration in albino rats as studied by the freezing-drying method and polarized light with deficiency of vitamin A or of vitamin B. Arch Pathol 1937;24:430–442.

    CAS  Google Scholar 

  91. Collins GH. The morphology of myelin degeneration in thiamine deficiency. In: Gubler CJ, Fujiwara M, Dreyfus PM (eds). Thiamine. New York, John Wiley & Sons: 1976; pp. 261–269.

    Google Scholar 

  92. Kark RAP, Brown WJ, Edgerton VR, Reynolds SF, Gibson G. Experimental thiamine deficiency: neuropathic and mitochondrial changes induced in rat muscle. Arch Neurol 1975;32:818–825.

    CAS  Google Scholar 

  93. Tode G. [Experimental B-avitaminosis in man.] Nisshin Igaku 1923;13:775, 1267, and Nisshin Igaku 1926;16:81.

    Google Scholar 

  94. Kagawa S. Studies on the relation of neuritis optica axialis to beriberi in Japan (Third report). Jpn J Med Sci VIII Int Med Ped Psych 1938;5:43–60.

    CAS  Google Scholar 

  95. Williams RD, Mason HL, Wilder RM, Smith BF. Observations on induced thiamine (vitamin B1) deficiency in man. Arch Intern Med 1940;66:783–799.

    Google Scholar 

  96. Williams RD, Mason HL, Smith BF, Wilder RM. Induced thiamine (vitamin B1) deficiency and the thiamine requirement of man: further observations. Arch Intern Med 1942;69:721–738.

    CAS  Google Scholar 

  97. Williams RD, Mason HL, Power MH, Wilder RM. Induced thiamine (vitamin B1) deficiency in man. Relation of depletion of thiamine to development of biochemical defect and of polyneuropathy. Arch Intern Med 1943;71:38–53.

    CAS  Google Scholar 

  98. Hoyt CS III, Billson FA. Low-carbohydrate diet optic neuropathy. Med J Aust 1977;1:65–66.

    Google Scholar 

  99. Hoyt CS, Billson FA. Optic neuropathy in ketogenic diet. Br J Ophthalmol 1979;63:191–194.

    CAS  Google Scholar 

  100. Suzuki S, Kumanomido T, Nagata E, Inoue J, Niikawa O. Optic neuropathy from thiamine deficiency. Intern Med 1997;36:532.

    CAS  Google Scholar 

  101. Van Noort BAA, Bos BJM, Klopping C, Wilmink JM. Optic neuropathy from thiamine deficiency in a patient with ulcerative colitis. Docum Ophthalmol 1987;67:45–51.

    Google Scholar 

  102. Casal G. Historia natural, y médica del Principado de Asturias. Obra posthuma. Madrid, M. Martín and F. M. de Mena, 1762.

    Google Scholar 

  103. Thiérry [Thiéry] F. Description díune maladie appelée mal de la rosa. J Med Chir Pharm 1755;2:337–346.

    Google Scholar 

  104. Roussel T. Traité de la Pellagre et des Pseudo-pellagres. Paris, J. B. Ballière, 1866.

    Google Scholar 

  105. Semba RD. Théophile Roussel and the elimination of pellagra from 19th century France. Nutrition 2000;16:231–233.

    CAS  Google Scholar 

  106. Strambio G. De Pellagra. Mediolani, 1786–1789.

    Google Scholar 

  107. Frapolli F. Animadversiones in morbum, vulgo pelagram. Milan, J. Galeatius, 1771.

    Google Scholar 

  108. Sambon LW. Progress report on the investigation of pellagra. J Trop Med Hyg 1910;13:289–300.

    Google Scholar 

  109. Report of the Pellagra Commission of the State of Illinois, November, 1911. Springfield, Illinois, State Journal Company, 1912.

    Google Scholar 

  110. Siler JF, Garrison PE, MacNeal WJ. The relation of methods of disposal of sewage to the spread of pellagra. Arch Intern Med 1914;14:453–474.

    Google Scholar 

  111. Searcy GH. An epidemic of acute pellagra. Alabama Med J 1907;20:387–392.

    Google Scholar 

  112. Goldberger J, Waring CH, Willets DG. The prevention of pellagra. A test of diet among institutional inmates. Public Health Reports 1915;30:3117–3131.

    Google Scholar 

  113. Goldberger J, Wheeler GA, Sydenstricker E. A study of the diet of nonpellagrous and of pellagrous households in textile mill communities in South Carolina in 1916. J Am Med Assoc 1918;71:944–949.

    CAS  Google Scholar 

  114. Goldberger J, Wheeler GA. The experimental production of pellagra in human subjects by means of diet. Hygienic Laboratory Bulletin 1920;120:7–116.

    Google Scholar 

  115. Goldberger J, Wheeler GA. Experimental black tongue of dogs and its relation to pellagra. Public Health Reports 1928;43:172–217.

    Google Scholar 

  116. Elvehjem CA, Madden RJ, Strong FM, Woolley DW. Relation of nicotinic acid and nicotinic acid amide to canine black tongue. Am Chem Soc J 1937;59:1767–1768.

    Google Scholar 

  117. Carpenter KJ (ed). Pellagra. Benchmark Papers in Biochemistry, Volume 2. Stroudsburg, Hutchinson Ross, 1981.

    Google Scholar 

  118. Etheridge EW. The Butterfly Caste: A Social History of Pellagra in the South. Westport, CT, Greenwood, 1972.

    Google Scholar 

  119. Roe DA. A Plague of Corn: The Social History of Pellagra. Ithaca, NY, Cornell University Press, 1973.

    Google Scholar 

  120. Paul AA. The calculation of nicotinic acid equivalents and retinol equivalents in the British diet. Nutrition (London) 1969;23:131–136.

    Google Scholar 

  121. Laguna J, Carpenter KJ. Raw versus processed corn in niacin-deficient diets. J Nutr 1951;45:21–28.

    CAS  Google Scholar 

  122. Jacob RA. Niacin. In: Bowman BA, Russell RM (eds). Present Knowledge in Nutrition. Eighth Edition. Washington, D.C., ILSI: 2001; pp. 199–206.

    Google Scholar 

  123. Spivak JL, Jackson DL. Pellagra: an analysis of 18 patients and a review of the literature. J Hopkins Med J 1977;140:295–309.

    CAS  Google Scholar 

  124. Gibson RS. Principles of Nutritional Assessment. Second Edition. New York, Oxford University Press, 2005.

    Google Scholar 

  125. Bender DA. Pellagra. In: Sadler MJ, Strain JJ, Caballero B (eds). Encyclopedia of Human Nutrition. San Diego, Academic: 1999; pp. 1297–1302.

    Google Scholar 

  126. Stannus HS. Pellagra and pellagra-like conditions in warm climates. Section I. Trop Dis Bull 1936;33:729–741.

    Google Scholar 

  127. Stannus HS. Pellagra and pellagra-like conditions in warm climates. Section II. Trop Dis Bull 1936;33:815–825.

    Google Scholar 

  128. Stannus HS. Pellagra and pellagra-like conditions in warm climates. Section III. Trop Dis Bull 1936;33:885–901.

    Google Scholar 

  129. Gillman J, Gillman T. Perspectives in Human Malnutrition: A Contribution to the Biology of Disease from a Clinical and Pathological Study of Chronic Malnutrition and Pellagra in the African. New York, Grune and Stratton, 1951.

    Google Scholar 

  130. Calderini CG. Notizie medico-statistiche sulla pellagra, dedotte dallo studio di oltre mille pellagrosi che subirono la cura balnearia nell’Ospitale Maggiore di Milano negli anni 1844, 45 e 46. Annali Universali di Medicina e Chirurgia 1847;123:372–432.

    Google Scholar 

  131. Rampoldi R. La pellagre e il mal d’occhi. Ann Ottal 1885–1886;14:99–112.

    Google Scholar 

  132. Roncoroni L. Sul campo visivo, la marcia e l’andatura nei pellagrosi (luglio 1890-febbraio 1891). Arch Psich Neuropat Antropol Crim Med Leg Torino 1891;12:114–123.

    Google Scholar 

  133. Bietti A. Sulle alterazioni oculari nella pellagra. Rivista Sperimentale di Frenitria e Medicina Legale delle Alienazioni Mentali 1901;27:202–204.

    Google Scholar 

  134. Calhoun FP. Visual fields in pellagra: a preliminary report. Ophthal Rec 1917;26:63–70.

    Google Scholar 

  135. Calhoun FP. Alterations in the visual fields associated with pellagra. Am J Ophthalmol 1918;1:834–847.

    Google Scholar 

  136. Ridlon JR. Pellagra: the value of the dietary treatment of the disease. Pub Health Rep 1916;31:1979–1999.

    Google Scholar 

  137. Welton CB. Eye symptoms of pellagra: preliminary report of examination of eyes of fifty-five patients. J Am Med Assoc 1909;53:1636–1637.

    Google Scholar 

  138. Fine M, Lachman GS. Retrobulbar neuritis in pellagra. Am J Ophthalmol 1937;20:708–714.

    Google Scholar 

  139. Whaley EM. Notes on the eye symptoms of one hundred cases of pellagra-a second report. Transactions of the National Association for the Study of Pellagra. Second Triennial Meeting at Columbia, South Carolina, October 3 and 4, 1912. Columbia, South Carolina, R. L. Bryan Company: 1914; pp. 343–345.

    Google Scholar 

  140. Krylov T. [Augenerkrankungen bei Pellagra.] Soviet Vestnek Oftal 1932;1:388–390.

    Google Scholar 

  141. Cronin HJ. Pellagra with ocular disturbance and psychosis. J Nerv Mental Dis 1933;78:35–44.

    Google Scholar 

  142. Levine J. Pellagra as a cause of optic neuritis: report of a case. Arch Ophthalmol 1934;12:902–909.

    Google Scholar 

  143. Scott HH. An investigation into an acute outbreak of ‘central neuritis’. Ann Trop Med Parasitol 1918;12:109–196.

    Google Scholar 

  144. Wright EJ. Disease due to A and B avitaminosis in Sierra Leone. West Afr Med J 1928;2:127–130.

    Google Scholar 

  145. Leitch JN. Dietetics in warm climates, including foodstuffs, their analyses and rôle in disease. London, Harrison & Sons, 1930.

    Google Scholar 

  146. Moore DF. Retrobulbar neuritis with pellagra in Nigeria. J Trop Med Hyg 1939;42:109–114.

    Google Scholar 

  147. Moore DGF. Partial loss of central acuity of vision for reading and distance in school children and its possible association with food deficiency. W Afr Med J 1930;4:46–48.

    Google Scholar 

  148. Moore DGF. Retrobulbar neuritis. W Afr Med J 1932;5:28–30.

    Google Scholar 

  149. Moore DF. Avitaminosis. W Afr Med J 1933;6:65–67.

    Google Scholar 

  150. Moore DGF. Retrobulbar neuritis and partial optic atrophy as sequelae of avitaminosis. Ann Trop Med Parasitol 1934;28:295–303.

    Google Scholar 

  151. Moore DGF. Manioc (kassava) as a native food in Nigeria. W Afr Med J 1934;7:97–98.

    Google Scholar 

  152. Moore DF. Nutritional retrobulbar neuritis followed by partial optic atrophy. Lancet 1937;1:1225–1227.

    Google Scholar 

  153. Moore DGF. Retrobulbar neuritis cum avitaminosis. W Afr Med J 1934;7:119–120.

    Google Scholar 

  154. Whitbourne D. Nutritional retrobulbar neuritis in children in Jamaica. Am J Ophthalmol 1947;30:169–171.

    Google Scholar 

  155. Carroll FD. Nutritional retrobulbar neuritis. Am J Ophthalmol 1947;30:172–176.

    Google Scholar 

  156. Landor JV, Pallister RA. Avitaminosis B2. Trans Roy Soc Trop Med Hyg 1935;29:121–134.

    Google Scholar 

  157. Goldberger J, Lillie RD. A note on an experimental pellagra-like condition in the albino rat. Public Health Reports 1926;41:1025–1029.

    CAS  Google Scholar 

  158. Gass JDM. Nicotinic acid maculopathy. Am J Ophthalmol 1973;76:500–510.

    CAS  Google Scholar 

  159. Millay RH, Klein ML, Illingworth DR. Niacin maculopathy. Ophthalmology 1988;95:930–936.

    CAS  Google Scholar 

  160. Spirn MJ, Warren FA, Guyer DR, Klancnik JM, Spaide RF. Optical cohorence tomography findings in nicotinic acid maculopathy. Am J Ophthalmol 2003;135:913–914.

    Google Scholar 

  161. Wills L, Mehta MM. Studies in ‘pernicious anaemia’ of pregnancy. Part I. Preliminary report. Indian J Med Res 1929–1930;17:777–792.

    Google Scholar 

  162. Wills L, Talpade SN. Studies in pernicious anemia of pregnancy. Part II. A survey of dietetic and hygienic conditions of women in Bombay. Indian J Med Res 1930–1931;18:283–306.

    CAS  Google Scholar 

  163. Wills L. Treatment of “pernicious anaemia of pregnancy” and “tropical anaemia” with special reference to yeast extract as a curative agent. Br Med J 1931;1:1059–10

    Google Scholar 

  164. Mitchell HK, Snell EE, Williams RJ. The concentration of “folic acid” [letter]. J Am Chem Soc 1941;63:2284

    CAS  Google Scholar 

  165. Stokstad ELR. Historical perspective on key advances in the biochemistry and physiology of folates. In: Picciano MF, Stokstad LR, Gregory JF III (eds). Folic Acid Metabolism in Health and Disease. New York, Wiley-Liss: 1992; pp. 1–21.

    Google Scholar 

  166. Jacques PF, Selhub J, Bostom AG, Wilson PWF, Rosenberg IH. The effect of folic acid fortification on plasma folate and total homocystein concentrations. N Engl J Med 1999;340:1449–1454.

    CAS  Google Scholar 

  167. Gregory JF III. Bioavailability of folate. Eur J Clin Nutr 1997;51(suppl 1):S54–S59.

    Google Scholar 

  168. Shane B. Folate chemistry and metabolism. In: Bailey LB (ed). Folate in Health and Disease. New York, Marcel Dekker: 1995; pp. 1–22.

    Google Scholar 

  169. Priest DG, Bunni MA. Folates and folate antagonists in cancer chemotherapy. In: Bailey LB (ed). Folate in Health and Disease. New York, Marcel Dekker, Inc.: 1995; pp. 379–403.

    Google Scholar 

  170. Morgan SL, Baggott JE. Folate antagonists in nonneoplastic disease: proposed mechanisms of efficacy and toxicity. In: Bailey LB (ed). Folate in Health and Disease. New York, Marcel Dekker, Inc.: 1995; pp. 405–433.

    Google Scholar 

  171. Knox DL, Chen MF, Guilarte TR, Dang CV, Burnette J. Nutritional amblyopia: folic acid, vitamin B-12, and other vitamins. Retina 1982;2:288–292.

    CAS  Google Scholar 

  172. Golnik KC, Schaible ER. Folate-responsive optic neuropathy. J Neuro Ophthalmol 1994;14:163–169.

    CAS  Google Scholar 

  173. Adams P, Chalmers TM, Foulds WS, Withey JL. Megaloblastic anaemia and vision. Lancet 1967;2:229–231.

    Google Scholar 

  174. Chisholm IA. Serum cobalamin and folate in the optic neuropathy associated with tobacco smoking. Can J Ophthalmol 1978;13:105–109.

    CAS  Google Scholar 

  175. Parry TE. Folate-responsive neuropathy. Presse Med 1994;23:131–137.

    CAS  Google Scholar 

  176. Combe JS. History of a case of anaemia. Trans Med Chir Soc Edinburgh 1824;1:194–204.

    Google Scholar 

  177. Addison T. Anaemia-disease of the supra-renal capsules. Lond Med Gaz 1849;43:517–518.

    Google Scholar 

  178. Leichtenstern O. Ueber progressive perniciöse Anämie bei Tabeskranken. Deutsch Med Wochenschr 1884;10:849–850.

    Google Scholar 

  179. Bastianelli G. Le sclerosi combinate del midollo spinale nelle anemie perniciose. Bullettino della Reale Accademia Medica di Roma 1895–1896;22:197–244.

    Google Scholar 

  180. Minot GR, Murphy WP. Treatment of pernicious anemia by a special diet. J Am Med Assoc 1926;87:470–476.

    CAS  Google Scholar 

  181. Castle WB. Observations on the etiologic relationship of achylia gastrica to pernicious anemia. I. The effect of the administration to patients with pernicious anemia of the contents of the normal human stomach recovered after the ingestion of beef muscle. Am J Med Sci 1929;178:748–764.

    Google Scholar 

  182. Rickes EL, Brink NG, Koniuszy FR, Wood TR, Folkers K. Crystalline vitamin B12. Science 1948;107:396–397.

    CAS  Google Scholar 

  183. Castle WB. The history of corrinoids. In: Babior BM (ed). Cobalamin Biochemistry and Pathophysiology. New York, Wiley Interscience: 1975; p. 1–17.

    Google Scholar 

  184. Carmel R. Prevalence of undiagnosed pernicious anemia in the elderly. Arch Intern Med 1996;156:1097–1100.

    CAS  Google Scholar 

  185. Krasinski SD, Russell RM, Samloff IM, et al. Fundic atrophic gastritis in an elderly population: effect on hemoglobin and several serum nutritional indicators. J Am Geriatr Soc 1986;34:800–806.

    CAS  Google Scholar 

  186. Higginbottom MC, Sweetman L, Nyhan WL. A syndrome of methylmalonic aciduria, homocystinuria, megaloblastic anemia and neurologic abnormalities in a vitamin B12-deficient breast-fed infant of a strict vegetarian. N Engl J Med 1978;299:317–323.

    CAS  Google Scholar 

  187. Linnell JC, Bhatt HR. Inborn errors of B12 metabolism and their management. In: Wickramasinghe SN (ed). Megaloblastic Anaemias, Clinical Haematology. London, Bailliere Tindall: 1995; pp. 567–601.

    Google Scholar 

  188. Patton N, Beatty S, Lloyd IC, Wraith JE. Optic atrophy in association with cobalamin C (cblC) disease. Ophthalmic Genet 2000;21:151–154.

    CAS  Google Scholar 

  189. Traboulsi EI, Silva JC, Geraghty MT, Maumenee IH, Valle D, Green WR. Ocular histopathologic characterization of cobalamin C type vitamin B12 defect with methylmalonic aciduria and homocysteinuria. Am J Ophthalmol 1992;113:269–280.

    CAS  Google Scholar 

  190. Salameh MM, Banda RW, Mohdi AA. Reversal of severe neurological abnormalities after vitamin B12 replacement in the Imerslund-Grasbeck syndrome. J Neurol 1991;238:349–350.

    CAS  Google Scholar 

  191. Altay C, Cetin M, Gumruk F, Irken G, Yetgin S, Laleli Y. Familiar selective vitamin B12 malabsorption (Imerslund-Grasbeck syndrome) in a pool of Turkish patients. Pediatr Hematol Oncol 1995;12:19–28.

    CAS  Google Scholar 

  192. Metz J. Cobalamin deficiency and the pathogenesis of nervous system disease. Ann Rev Nutr 1992;12:59–79.

    CAS  Google Scholar 

  193. Troncoso J, Mancall EL, Schatz NJ. Visual evoked responses in pernicious anemia. Arch Neurol 1979;36:168–169.

    CAS  Google Scholar 

  194. Cohen H. Optic atrophy as the presenting sign in pernicious anaemia. Lancet 1936;2:1202–1203.

    Google Scholar 

  195. Lerman S, Feldmahn AL. Centrocecal scotomata as the presenting sign in pernicious anemia. Arch Ophthalmol 1961;65:381–385.

    CAS  Google Scholar 

  196. Hine ML. Subacute combined degeneration of cord in pernicious anaemia with retrobulbar neuritis. Proc Roy Soc Med 1936;29:386.

    Google Scholar 

  197. Turner JWA. Optic atrophy associated with pernicious anemia. Brain 1940;63:225–236.

    Google Scholar 

  198. Foulds WS, Chisholm IA, Stewart JB, Watson TM. The optic neuropathy of pernicious anemia. Arch Ophthalmol 1969;82:427–432.

    CAS  Google Scholar 

  199. Foulds WS, Chisholm IA, Brontë-Stewart J, Wilson TM. Vitamin B12 absorption in tobacco amblyopia. Br J Ophthalmol 1969;53:393–397.

    CAS  Google Scholar 

  200. Watson-Williams EJ, Bottomly AC, Ainley RG, Phillips CI. Absorption of vitamin B12 in tobacco amblyopia. Br J Ophthalmol 1969;53:549–552.

    CAS  Google Scholar 

  201. Chisholm IA. Serum cobalamin and folate in the optic neuropathy associated with tobacco smoking. Can J Ophthalmol 1978;13:105–109.

    CAS  Google Scholar 

  202. Björkenheim B. Optic neuropathy caused by vitamin-B12 deficiency in carriers of the fish tapeworm Diphyllobothrium latum. Lancet 1966;1:688–690.

    Google Scholar 

  203. Stambolian D, Behrens M. Optic neuropathy associated with vitamin B12 deficiency. Am J Ophthalmol 1977;83:465–468.

    CAS  Google Scholar 

  204. Larner AJ. Visual failure caused by vitamin B12 deficiency optic neuropathy. Int J Clin Pract 2004;58:977–978.

    CAS  Google Scholar 

  205. Hind VMD. Degeneration in the peripheral visual pathway of vitamin B12-deficient monkeys. Trans Ophthalmol Soc UK 1970;90:839–846.

    CAS  Google Scholar 

  206. Hind VMD. The histology of vitamin B12 deficiency optic neuropathy in monkeys. In: Cant JS (ed). The optic nerve. St. Louis, C. V. Mosby: 1972; pp. 257–269.

    Google Scholar 

  207. Enoksson P, Nordén Å. Vitamin B12 deficiency affecting the optic nerve. Acta Med Scand 1960;167:199–208

    CAS  Google Scholar 

  208. Olivarius BF. Opticusatrofi ved anaemia perniciosa. Nord Med 1961;65:157–159.

    CAS  Google Scholar 

  209. Hamilton HE, Ellis PP, Sheets RF. Visual impairment due to optic neuropathy in pernicious anemia: report of a case and review of the literature. Blood 1959;14:387–385.

    Google Scholar 

  210. Olivarius BF, Jensen L. Retrobulbar neuritis and optic atrophy in pernicious anemia. Acta Ophthalmol 1961;39:190–197.

    Google Scholar 

  211. Victor M. Tobacco-alcohol amblyopia: a critique of current concepts of this disorder, with special reference to the role of nutritional deficiency in its causation. Arch Ophthalmol 1963;70:313–318.

    CAS  Google Scholar 

  212. Dunphy EB. Alcohol and tobacco amblyopia: a historical survey. XXXI De Schweinitz Lecture. Am J Ophthalmol 1969;68:569–578.

    CAS  Google Scholar 

  213. Potts AM. Tobacco amblyopia. Surv Ophthalmol 1973;17:313–339.

    CAS  Google Scholar 

  214. Ridley H. Opening paper. Discussion on amblyopia. Trans Ophthalmol Soc U K 1931;50:429–454.

    Google Scholar 

  215. Traquair HM. Toxic amblyopia, including retrobulbar neuritis. Trans Ophthalmol Soc UK 1931;50:351–385.

    Google Scholar 

  216. Evans PJ. Tobacco amblyopia. Trans Ophthalmol Soc UK 1939;59:241–252.

    Google Scholar 

  217. Freeman AG, Heaton JM. The aetiology of retrobulbar neuritis in Addisonian pernicious anaemia. Lancet 1961;1:908–911.

    CAS  Google Scholar 

  218. Chisholm IA, Pettigrew AR. Biochemical observations in toxic optic neuropathy. Trans Ophthalmol Soc UK 1970;90:827–837.

    CAS  Google Scholar 

  219. Lessell S. Experimental cyanide optic neuropathy. Arch Ophthalmol 1971;86:194–204.

    CAS  Google Scholar 

  220. Lessell S. Comment. What is the cause of alcohol and tobacco amblyopia? In: Brockhurst RJ, Boruchoff SA, Hutchinson BT, Lessell S (eds). Controversy in Ophthalmology. Philadelphia, WB Saunders: 1977; pp. 873–874.

    Google Scholar 

  221. Schepens CL. Is tobacco amblyopia a deficiency disease? Trans Ophthalmol Soc UK 1946;66:309–331.

    Google Scholar 

  222. Evans PJ. Opening paper. Discussion on amblyopia. Trans Ophthalmol Soc U K 1931;50:397–411.

    Google Scholar 

  223. Hebert JR, Kabat GC. Differences in dietary intake associated with smoking status. Eur J Clin Nutr 1990;44:185–193.

    CAS  Google Scholar 

  224. La Vecchia C, Negri E, Franceschi S, Parazzini F, Decarli A. Differences in dietary intake with smoking, alcohol, and education. Nutr Cancer 1992;17:297–304.

    Google Scholar 

  225. English RM, Najman JM, Bennett SA. Dietary intake of Australian smokers and nonsmokers. Aust N Z J Public Health 1997;21:141–146.

    CAS  Google Scholar 

  226. Brasche S, Winkler G, Heinrich J. Dietary intake and smoking—results from a dietary survey in Erfurt in 1991/92. Z Ernahrungswiss 1998;37:211–214.

    CAS  Google Scholar 

  227. Thompson RL, Margetts B, Jackson AA. Smoking: effects on diet and nutritional status. In: Sadler MJ, Strain JJ, Caballero B (eds). Encyclopedia of Human Nutrition. San Diego, Academic: 1999; pp. 1759–1764.

    Google Scholar 

  228. Phillips EL, Arnett DK, Himes JH, McGovern PG, Blackburn H, Luepker RV. Differences and trends in antioxidant dietary intake in smokers and non-smokers, 1980–1992: The Minnesota Heart Survey. Ann Epidemiol 2000;10:417–423.

    CAS  Google Scholar 

  229. Seal CJ, Ford CL, Day CP. Alcoholism: effects on nutritional status. In: Sadler MJ, Strain JJ, Caballero B (eds). Encyclopedia of Human Nutrition. San Diego, Academic: 1999; pp. 52–59.

    Google Scholar 

  230. Carroll FD. Analysis of fifty-five cases of tobacco-alcohol amblyopia. Arch Ophthalmol 1935;14:421–434.

    Google Scholar 

  231. Carroll FD. “Alcohol” amblyopia, pellagra, polyneuritis: report of ten cases. Arch Ophthalmol 1936;16:919–926

    CAS  Google Scholar 

  232. Johnson LC. Alcohol-tobacco (toxic) amblyopia treated with thiamin chloride. Arch Ophthalmol 1939;21:602–603.

    Google Scholar 

  233. Carroll FD. Etiology and treatment of tobacco-alcohol amblyopia. Part I. Am J Ophthalmol 1944;27:713–725.

    Google Scholar 

  234. Carroll FD. Etiology and treatment of tobacco-alcohol amblyopia. Part II. Am J Ophthalmol 1944;27:847–863.

    Google Scholar 

  235. Dreyfus PM. Blood transketolase levels in tobacco-alcohol amblyopia. Arch Ophthalmol 1965;74:617–620.

    CAS  Google Scholar 

  236. Heaton JM, McCormick AJA, Freeman AG. Tobacco amblyopia: a clinical manifestation of vitamin-B12 deficiency. Lancet 1958;2:286–290.

    CAS  Google Scholar 

  237. Ainsley RG. The Fransworth-Munsell 100 hue test in tobacco amblyopia. Trans Ophthalmol Soc UK 1970;90:765–771.

    Google Scholar 

  238. Harrington DO. What is the etiology of alcohol and tobacco amblyopia? In: Brockhurst RJ, Boruchoff SA, Hutchinson BT, Lessell S (eds). Controversy in Ophthalmology. Philadelphia, WB Saunders: 1977; pp. 866–872.

    Google Scholar 

  239. Rizzo JF, Lessell S. Tobacco amblyopia. Am J Ophthalmol 1993;116:84–87.

    Google Scholar 

  240. Chisholm IA, Bronte-Stewart J, Foulds WS. Hydroxocobalamin versus cyanocobalamin in the treatment of tobacco amblyopia. Lancet 1967;2:450–457.

    CAS  Google Scholar 

  241. Foulds WS, Chisholm IA, Bronte-Stewart J, Reid HCR. The investigation and therapy of the toxic amblyopias. Trans Ophthalmol Soc UK 1970;99:739–763.

    Google Scholar 

  242. Crews SJ, James B, Marsters JB, West RH. Drug and nutritional factors in optic neuropathy. Trans Ophthalmol Soc UK 1970;90:773–794.

    CAS  Google Scholar 

  243. Wokes F. Tobacco amblyopia. Lancet 1958;2:526–527.

    Google Scholar 

  244. Smith ABM. Retrobulbar neuritis in Addisonian pernicious anaemia. Lancet 1961;1:1001–1002.

    Google Scholar 

  245. Dang CV. Tobacco-alcohol amblyopia: a proposed biochemical basis for pathogenesis. Med Hypotheses 1981;7:1317–1328.

    CAS  Google Scholar 

  246. Victor M, Mancall EL, Dreyfus PM. Deficiency amblyopia in the alcoholic patient. A clinicopathologic study. Arch Ophthalmol 1960;64:1–33.

    CAS  Google Scholar 

  247. Victor M, Dreyfus PM. Tobacco-alcohol amblyopia: further comments on its pathology. Arch Ophthalmol 1965;74:649–657.

    CAS  Google Scholar 

  248. Carroll FD. Nutritional amblyopia. Arch Ophthalmol 1966;76:406–411.

    CAS  Google Scholar 

  249. Foulds WS, Pettigrew AR. Tobacco-alcohol amblyopia. In: Brockhurst RJ, Boruchoff SA, Hutchinson BT, Lessell S (eds). Controversy in Ophthalmology. Philadelphia, WB Saunders: 1977; pp. 851–865.

    Google Scholar 

  250. Samples JR, Younge BR. Tobacco-alcohol amblyopia. J Clin Neuro Ophthalmol 1981;1:213–218.

    CAS  Google Scholar 

  251. Dinser F. Beobachtungen von Neuritis retrobulbaris (Neuritis axialis [Wilbrand und Sänger]) bei Kriegsteilnehmern. Klin Monatsbl Augenh 1919;63:701–718.

    Google Scholar 

  252. Junius [P]. Zur Frage der ätiologisch unklaren Fälle von Sehnervenschwund, insbesondere bei Kriegsteilnehmern. Zeitschrift Augenh 1919;41:305–323.

    Google Scholar 

  253. Kafka. [Diskussion] Zeitschrift Augenh 1919;41:286.

    Google Scholar 

  254. Szymanowsky K. Zur Frage der retrobulbären Neuritis bei Kriegsteilnehmern. Klin Monatsbl Augenh 1919;62:631–643.

    Google Scholar 

  255. Scheffler W. Kriegserfahrungen auf dem Gebiete der retrobulbären Neuritis. Klin Monatsbl Augenh 1919;63:718–728.

    Google Scholar 

  256. Bachstez E, Purtscher [O]. Über die Häufung retrobulbärer Neuritiden einschließlich toxischer Amblyopien gegenüber der Zeit vor dem Kriege. Zeitschrift Augenh 1920;44:38–44.

    Google Scholar 

  257. Jendralski F. Die Intoxikationsamblyopie (Tabak, Alkohol) vor, in und nach dem Kriege. Deutsche med Wochenschrift 1922;48:1207–1209.

    Google Scholar 

  258. Grande F, Peraita M. Avitaminosis y sistema nervioso. Madrid, Miguel Servet, 1941.

    Google Scholar 

  259. Peraita M. Deficiency neuropathies observed in Madrid during the Civil War (1936–9). Br Med J 1946;2:784.

    Google Scholar 

  260. Pillat A. Sehnervenschäden durch Vitaminmangel. Klin Monats Augenh 1939;103:97–98.

    CAS  Google Scholar 

  261. Dekking HM. Tropical nutritional amblyopia (“camp eyes”). Ophthalmologica 1947;113:65–92

    Google Scholar 

  262. Ridley H. Ocular manifestations of malnutrition in released prisoners of war from Thailand. Br J Ophthalmol 1945;29:613–618.

    Google Scholar 

  263. Rodger FC. Nutritional amblyopia. A statistical report of the course and progress of two hundred and thirty-eight cases. Arch Ophthalmol 1952;47:570–583.

    CAS  Google Scholar 

  264. Rodger FC, Sinclair HM. Metabolic and Nutritional Eye Diseases. Springfield, Charles C. Thomas, 1969.

    Google Scholar 

  265. Livingston PC. Ocular disturbances associated with malnutrition. Trans Ophthalmol Soc UK 1946;66:19–44.

    Google Scholar 

  266. Hobbs HE. Ocular disturbances associated with malnutrition. General discussion. Trans Ophthalmol Soc UK 1946;66:116–122.

    Google Scholar 

  267. Hobbs HE, Forbes FA. Visual defects in prisoners-of-war from the Far East. Lancet 1946;2:149–153.

    Google Scholar 

  268. McDaniel FL, White BV, Thompson CM. Malnutrition in repatriated prisoners of war. US Naval Med Bull 1946;46:793–810.

    CAS  Google Scholar 

  269. Roberts WL, Willcockson TH. Postneuritic optic atrophy in repatriated prisoners of war. Am J Ophthalmol 1947;30:165–168.

    Google Scholar 

  270. Burgess RC. Deficiency diseases in prisoners-of-war at Changi, Singapore, February 1942, to August, 1945. Lancet 1946;2:411–418.

    Google Scholar 

  271. Smith DA, Woodruff MFA. Deficiency diseases in Japanese prison camps. Medical Research Council, Special Report Series No. 274. London, Her Majesty’s Stationery Office, 1951.

    Google Scholar 

  272. Shapland CD. Ocular disturbances associated with malnutrition. General discussion. Trans Ophthalmol Soc UK 1946;66:77–95.

    Google Scholar 

  273. Cruickshank EK. Painful feet in prisoners-of-war in the Far East: review of 500 cases. Lancet 1946;2:369–372.

    Google Scholar 

  274. Shapland CD. Ocular disturbances associated with malnutrition. J Roy Army Med Corp 1946;87:253–265.

    Google Scholar 

  275. Williamson AD. Ocular signs in the prisoner of war from the Far East [letter]. Br Med J 1946;1:545–546.

    Google Scholar 

  276. Spillane JD. Nutritional Disorders of the Nervous System. Edinburgh, E & S Livingstone, 1947.

    Google Scholar 

  277. Wilkinson PB, King A. Amblyopia due to a vitamin deficiency. Lancet 1944;1:528–531.

    Google Scholar 

  278. Smith DA. Ocular disturbances associated with malnutrition. General discussion. Trans Ophthalmol Soc UK 1946;66:111–116.

    Google Scholar 

  279. Fraser JD. Ocular disturbances associated with malnutrition. General discussion. Trans Ophthalmol Soc UK 1946;66:96–98.

    Google Scholar 

  280. Bell PG, O’Neill JC. Optic atrophy in Hong Kong prisoners of war. Canad Med Assoc J 1947;56:475–481.

    Google Scholar 

  281. Adamson JD, Tisdale PK, Brereton DC, Card LWB. Residual disabilities in Hong Kong repatriates. Canad Med Assoc J 1947;56:481–486.

    Google Scholar 

  282. Philps AS. Ocular disturbances associated with malnutrition. General discussion. Trans Ophthalmol Soc UK 1946;66:99–102.

    Google Scholar 

  283. Cross AG. Ocular disturbances associated with malnutrition. General discussion. Trans Ophthalmol Soc UK 1946;66:102–104.

    Google Scholar 

  284. Hazelton AR. The nature of starvation amblyopia. J Roy Army Med Corp 1946;86:171–178.

    Google Scholar 

  285. Dansey-Browning GC, Rich WM. Ocular signs in the prisoner of war returned from the Far East. Br Med J 1946;1:20–21.

    Google Scholar 

  286. Rich WM. Ocular signs in P.O.W.s from the Far East [letter]. Br Med J 1946;1:330–331.

    Google Scholar 

  287. Denny-Brown D. Neurological conditions resulting from prolonged and severe dietary restriction (case reports in prisoners-of-war, and general review). Medicine 1946;26:41–113.

    Google Scholar 

  288. Bloom SM, Merz EH, Taylor WW. Nutritional amblyopia in American prisoners of war liberated from the Japanese. Am J Ophthalmol 1946;29:1248–1257.

    Google Scholar 

  289. Beam AD. Amblyopia due to dietary deficiency: report of eight cases. Arch Ophthalmol 1946;36:113–118.

    Google Scholar 

  290. Beam AD. Amblyopia due to dietary deficiency. Am J Ophthalmol 1947;30:66–72.

    Google Scholar 

  291. Pohlman ME, Ritter EF Jr. Observations on vitamin deficiencies: in an eye, ear, nose, and throat clinic of a Japanese prison hospital. Am J Ophthalmol 1952;35:228–230.

    CAS  Google Scholar 

  292. De Ocampo G, Yambao CV, Mañagas PJ, Sevilla CL. Epidemic retrobulbar neuritis in Philippines during the Japanese occupation. Am J Ophthalmol 1947;30:698–704.

    Google Scholar 

  293. Raadt OLE de. Pellagra in the oto-neurology and rhino-laryngology. Leiden, Universitaire Pers Leiden, 1947.

    Google Scholar 

  294. Mulock Houwer AW. Amblyopia cum polyneuropathia caused by starvation. Ophthalmologica 1946;112:177–192.

    Google Scholar 

  295. Lian SB. Camp amblyopia. Ophthalmologica 1947;113:38–44.

    Google Scholar 

  296. Spillane JD, Scott GI. Obscure neuropathy in the Middle East. Lancet 1945;2:261–264.

    Google Scholar 

  297. Friemann W, Magun R. Ernährungsschäden des Nervensystems bei Kriegsgefangenen (unter besonderer Berücksichtigung der Sehstörungen. Graefes Arch Ophthalmol 1949;149:437–488.

    Google Scholar 

  298. Obal A. Nutritional amblyopia. Am J Ophthalmol 1951;34:857–865.

    CAS  Google Scholar 

  299. Stannus HS. Ocular disturbances associated with malnutrition. General discussion. Trans Ophthalmol Soc UK 1946;66:123–131.

    Google Scholar 

  300. King JH Jr, Passmore JW. Nutritional amblyopia: a study of American prisoners of war in Korea. Am J Ophthalmol 1955;39:173–186.

    Google Scholar 

  301. Goldsmith H. Ocular signs in P.O.W.s from the Far East [letter]. Br Med J 1946;1:407.

    Google Scholar 

  302. Adolph WH, Greaves AV, Lawney JC, Robinson HL. Nutritional disorders in Japanese internment camps. War Med 1944;5:349–355.

    Google Scholar 

  303. Whitacre FE. American civilians in a Japanese internment camp. J Am Med Assoc 1944;124:652–653.

    Google Scholar 

  304. Gupta LM. Malnutrition in recovered prisoners of war and internees; Report of 10 cases evacuated from Thailand. Br Med J 1946;1:643–646.

    Google Scholar 

  305. Reid JA, Wilson T. Report on nutrition, and discussion of the main causes of death, “F” force, Thailand. J Roy Army Med Corp 1947;89:149–165

    Google Scholar 

  306. Churchill MH. Dietary deficiency diseases among prisoners of war. J Roy Army Med Corp 1945;85:294–298.

    Google Scholar 

  307. Dunlop EE. Medical experiences in Japanese captivity. Brit Med J 1946;2:481–486.

    Google Scholar 

  308. Durran J. Ocular signs in the prisoner of war from the Far East [letter]. Brit Med J 1946;1:626–627.

    Google Scholar 

  309. Román GC. An epidemic in Cuba of optic neuropathy, sensorineural deafness, peripheral sensory neuropathy and dorsolateral myeloneuropathy. J Neuro Sci 1994;127:11–28.

    Google Scholar 

  310. Figure from Dirección Nacional de Estadísticas, Ministerio de Salud Pública, Cuba

    Google Scholar 

  311. Román G. Misión a Cuba: La verdadera historia de la epidemia que cambió el derrotero de la isla de Cuba. Barcelona, Prous Science, 2000.

    Google Scholar 

  312. Hedges TR, Hirano M, Tucker K, Caballero B. Epidemic optic and peripheral neuropathy in Cuba: a unique geopolitical public health problem. Surv Ophthalmol 1997;41:341–353.

    Google Scholar 

  313. The Cuba Neuropathy Field Investigation Team. Epidemic optic neuropathy in Cuba-clinical characterization and risk factors. N Engl J Med 1995;333:1176–1182.

    Google Scholar 

  314. Mas Bermejo P, Rodriguez R, Barcelo C, et al. Neuropatía epidémica en Cuba: un análisis epidemiológico. Ministerio de Salud Pública, La Habana: 1993; pp. 1–14.

    Google Scholar 

  315. Gay J, Porrata C, Hernández M, et al. Dietary factors in epidemic neuropathy on the Isle of Youth, Cuba. Bull PAHO 1995;29:25–36.

    CAS  Google Scholar 

  316. Sadun AA, Martone JF, Muci-Mendoza R, et al. Epidemic optic neuropathy in Cuba: eye findings. Arch Ophthalmol 1994;112:691–699.

    CAS  Google Scholar 

  317. Lincoff NS, Odel JG, Hirano M. Letter from Havana: ‘Outbreak’ of optic and peripheral neuropathy in Cuba? JAMA 1993;270:511–518.

    CAS  Google Scholar 

  318. Santiesteban R, Luis S, Marquez M, et al. Aspectos neuro-oftalmológicos de la neuropatía epidémica en Cuba: Estudio de 602 pacientes. Instituto de Neurología y Neurocirurgía, La Habana: 1993; pp. 1–22.

    Google Scholar 

  319. Borrajero I, Pérez JL, Domínguez C, et al. Epidemic neuropathy in Cuba: morphological characterization of peripheral nerve lesions in sural nerve biopsies. J Neurol Sci 1994;127:68–76.

    CAS  Google Scholar 

  320. Bates C, Macias-Matos C, Rodriguez-Ojea A, Chi N, Jiminez S, Zulueta D. Reply to A Ascherio [letter]. Am J Clin Nutr 1997;65:1093.

    CAS  Google Scholar 

  321. Ascherio A. Antimetabolites and an optic neuropathy epidemic in Cuba [letter]. Am J Clin Nutr 1997;65:1092.

    CAS  Google Scholar 

  322. Johns DR, Neufeld MJ, Hedges TR III. Mitochondrial DNA mutations in Cuban optic and peripheral neuropathy. J Neuro-Ophthalmol 1994;14:135–140.

    CAS  Google Scholar 

  323. Johns DR, Sadun AA. Cuban epidemic optic neuropathy: mitochondrial DNA analysis. J Neuro-Ophthalmol 1994;14:130–134.

    CAS  Google Scholar 

  324. Newman NJ, Torroni A, Brown MD, et al. Epidemic neuropathy in Cuba not associated with mitochondrial DNA mutations found in Leber’s hereditary optic neuropathy patients. Am J Ophthalmol 1994;118:158–168.

    CAS  Google Scholar 

  325. Román GC. On politics and health: an epidemic of neurologic disease in Cuba. Ann Intern Med 1995;122:530–533.

    Google Scholar 

  326. Bates CJ. Intake and status in healthy Havana men, 2 years after the Cuban epidemic neuropathy. Br J Nutr 2001;85:641–642.

    CAS  Google Scholar 

  327. Macias-Matos C, Rodriguez-Ojea A, Chi N, Jimenez S, Zulueta D, Bates CJ. Biochemical evidence of thiamine depletion during the Cuban neuropathy epidemic, 1992–1993. Am J Clin Nutr 1996;64:347–353.

    CAS  Google Scholar 

  328. Bowman BA, Bern C, Philen RM. Nothing’s simple about malnutrition: complexities raised by epidemic neuropathy in Cuba. Am J Clin Nutr 1996;64:383–384.

    CAS  Google Scholar 

  329. Arnaud J, Fleites-Mestre P, Chassagne M, et al. Vitamin B intake and status in healthy Havanan men, 2 years after the Cuban neuropathy epidemic. Br J Nutr 2001;85:741–748.

    CAS  Google Scholar 

  330. Arnaud J, Fleites P, Chassagne M, et al. Seasonal variations of antioxidant imbalance in Cuban healthy men. Eur J Clin Nutr 2001;55:29–38.

    CAS  Google Scholar 

  331. Barnouin J, Cristiá RP, Chassagne M, et al. Vitamin and nutritional status in Cuban smokers and nonsmokers in the context of an emerging epidemic neuropathy. Int J Vitam Nutr Res 2000;70:126–138.

    CAS  Google Scholar 

  332. Ordúñez-Garcia PO, Nieto FJ, Espinosa-Brito AD, Caballero B. Cuban epidemic optic neuropathy, 1991 to 1994: history repeats itself a century after the “Amblyopia of the Blockade.” 1991 to 1994: history repeats itself a century after the “Amblyopia of the Blockade.” Am J Pub Health 1996 1996;86:738–743

    Google Scholar 

  333. Perez-Stable E. Epidemic neuropathy in Cuba [letter]. Ann Intern Med 1995;123:734.

    CAS  Google Scholar 

  334. De Long DM. Epidemic neuropathy in Cuba [letter]. Ann Intern Med 1995;123:734.

    Google Scholar 

  335. Román GC. Epidemic neuropathy in Cuba: reply [letter]. Ann Intern Med 1995;123:734.

    Google Scholar 

  336. Frisén L. Fundus changes in acute malnutritional optic neuropathy. Arch Ophthalmol 1983;101:577–579.

    Google Scholar 

  337. Cullom ME, Heher KL, Miller NR, Savino PJ, Johns DR. Leber’s hereditary optic neuropathy masquerading as tobacco-alcohol amblyopia. Arch Ophthalmol 1993;111;1482–1485.

    CAS  Google Scholar 

  338. Kerrison JB. Optic neuropathies caused by toxins and adverse drug reactions. Ophthalmol Clin North Am 2004;17:481–488.

    Google Scholar 

  339. Blyth AW. The composition of cows’ milk in health and disease. J Chem Soc 1879;35:530–539.

    CAS  Google Scholar 

  340. McCollum EV, Kennedy C. The dietary factors operating in the production of polyneuritis. J Biol Chem 1916;24:491–502.

    CAS  Google Scholar 

  341. Emmett AD, Luros GO. Water soluble vitamins. I. Are the antineuritic and the growth-promoting watersoluble B vitamines the same? J Biol Chem 1920;43:265–287.

    CAS  Google Scholar 

  342. Smith MI, Hedrick EG. Some nutrition experiments with brewers’ yeast with especial reference to its value in supplementing certain deficiencies in experimental rations. US Public Health Rep 1926;41:201–207.

    CAS  Google Scholar 

  343. Warburg O, Christian W. Über ein neues Oxydationsferment und sein Absorptionsspektrum. Biochem Zeitschr 1932;254:438–458.

    CAS  Google Scholar 

  344. Kuhn R, György P, Wagner-Jauregg T. Über eine neue Klasse von Naturfarbstoffen (Vorläufige Mitteilung). Berichte der Deutschen Chemischen Gesellschaft 1933;66:317–320.

    Google Scholar 

  345. Kuhn R, György P, Wagner-Jauregg T. Über Ovoflavin, den Farbstoff des Eiklars. Berichte der Deutschen Chemischen Gesellschaft 1933;66:576–580.

    Google Scholar 

  346. Booher LE. The concentration and probable chemical nature of vitamin G. J Biol Chem 1933;102:39–46.

    CAS  Google Scholar 

  347. Kuhn R, Reinemund K, Kaltschmitt H, Ströbele R, Trischmann H. Synthetisches 6,7-Dimethyl-9-driboflavin. Naturwissenschaften 1935;23:260.

    CAS  Google Scholar 

  348. Karrer P, Schöpp K, Benz F. Synthesen von Flavinen IV. Helv Chim Acta 1935;18:426–429.

    CAS  Google Scholar 

  349. Spoerl E, Huhle M, Seiler T. Induction of cross-links in corneal tissue. Exp Eye Res 1998;66:97–103.

    CAS  Google Scholar 

  350. Mulroy L, Kim J, Wu I, et al. Photochemical keratodesmos for repair of lamellar corneal incisions. Invest Ophthalmol Vis Sci 2000;41:3335–3340.

    CAS  Google Scholar 

  351. Bates CJ. Bioavailability of riboflavin. Eur J Clin Nutr 1997;51(suppl 1):S38–S42.

    Google Scholar 

  352. Zempleni J, Galloway JR, McCormick DB. Pharmacokinetics of orally and intravenously administered riboflavin in healthy humans. Am J Clin Nutr 1996;63:54–66.

    CAS  Google Scholar 

  353. Jusko WJ, Levy G. Absorption, protein binding and elimination of riboflavin. In: Rivlin RS (ed). Riboflavin. New York, Plenum: 1975; pp. 99–152.

    Google Scholar 

  354. Merrill AH Jr, Lambeth JD, Edmondson DE, McCormick DB. Formation and mode of action of flavoproteins. Annu Rev Nutr 1981;1:281–317.

    CAS  Google Scholar 

  355. Jamieson CP, Obeid OA, Powell-Tuck J. The thiamin, riboflavin and pyridoxine status of patients on emergency admission to hospital. Clin Nutr 1999;18:87–91.

    CAS  Google Scholar 

  356. Faci Vega M, Ortega RM, Requejo AM, et al. Situación dietética y bioquímica en riboflavina de un colectivo de jóvenes de la Comunidad de Madrid. Nutr Hosp 2001;16:92–96.

    CAS  Google Scholar 

  357. El-Hazmi MA, Warsy AS. Riboflavin status in Saudi Arabia—a comparative study in different regions. Trop Geogr Med 1989;41:22–25.

    CAS  Google Scholar 

  358. Bates CJ, Prentice AM, Watkinson M, et al. Efficacy of a food supplement in correcting riboflavin deficiency in pregnant Gambian women. Hum Nutr Clin Nutr 1984;38C:363–374.

    Google Scholar 

  359. Ajayi OA. Biochemical ariboflavinosis among Nigerian rural school children. Hum Nutr Clin Nutr 1984;38:383–389.

    CAS  Google Scholar 

  360. Ajayi OA, James OA. Effect of riboflavin supplementation on riboflavin nutriture of a secondary school population in Nigeria. Am J Clin Nutr 1984;39:787–791.

    CAS  Google Scholar 

  361. Wacker J, Fruhauf J, Schulz M, Chiwora FM, Volz J, Becker K. Riboflavin deficiency and preeclampsia. Obstet Gynecol 2000;96:38–44.

    CAS  Google Scholar 

  362. Lo CS. Riboflavin status of adolescents in southern China: average intake of riboflavin and clinical findings. Med J Aust 1984;141:635–637.

    CAS  Google Scholar 

  363. Cunha DF, Cunha SF, Unamuno MR, Vannucchi H. Serum levels assessment of vitamin A, E, C, B2 and carotenoids in malnourished and non-malnourished hospitalized elderly patients. Clin Nutr 2001;20:167–170.

    CAS  Google Scholar 

  364. Rosado JL, Bourges H, Saint-Martin B. Deficiencia de vitaminas y minerales en México. Una revisión crítica del estado de la información: II. Deficiencia de vitaminas. Salud Publica Mex 1995;37:452–461.

    CAS  Google Scholar 

  365. Boisvert WA, Castañeda C, Mendoza I, et al. Prevalence of riboflavin deficiency among Guatemalan elderly people and its relationship to milk intake. Am J Clin Nutr 1993;58:85–90.

    CAS  Google Scholar 

  366. Vudhivai N, Ali A, Pongpaew P, et al. Vitamin B1, B2, and B6 status of vegetarians. J Med Assoc Thai 1991;74:465–470.

    CAS  Google Scholar 

  367. Cole HS, Lopez R, Cooperman JM. Riboflavin deficiency in children with diabetes mellitus. Acta Diabetol Lat 1976;13:25–29.

    CAS  Google Scholar 

  368. Rivlin RS. Riboflavin and cancer. In: Rivlin RS (ed). Riboflavin. New York, Plenum: 1975; pp. 369–391.

    Google Scholar 

  369. Steier M, Lopez R, Cooperman JM. Riboflavin deficiency in infants and children with heart disease. Am Heart J 1976;92:139–143.

    CAS  Google Scholar 

  370. Goldsmith GA. Riboflavin deficiency. In: Rivlin RS (ed). Riboflavin. New York, Plenum: 1975; pp. 221–244.

    Google Scholar 

  371. Sebrell WH, Butler RE. Riboflavin deficiency in man. A preliminary note. Publ Health Rep 1938;53:2282–2284.

    CAS  Google Scholar 

  372. Powell SR, Schwab IR. Nutritional disorders affecting the peripheral cornea. Int Ophthalmol Clin 1986;26:137–146.

    CAS  Google Scholar 

  373. Sydenstricker VP. Clinical manifestations of ariboflavinosis. Am J Pub Health 1941;31:344–350.

    Google Scholar 

  374. Sebrell WH. Identification of riboflavin deficiency in human subjects. Fed Proc 1979;38:2694–2495.

    CAS  Google Scholar 

  375. Zilstorff-Pedersen K. To tilfælde af ariboflavinosis. Helbredt ved behandling med store doser riboflavin. Ugesk Laeger 1927;114:393–395.

    Google Scholar 

  376. Sydenstricker VP, Sebrell WH, Cleckley HM, Kruse HD. The ocular manifestations of ariboflavinosis: a progress note. J Am Med Assoc 1940;114:2437–2445.

    Google Scholar 

  377. Kruse HD, Sydenstricker VP, Sebrell WH, Cleckley HM. Ocular manifestations of ariboflavinosis. Pub Health Rep 1940;55:157–169.

    CAS  Google Scholar 

  378. Sydenstricker VP, Kelly AR, Weaver JW. Ariboflavinosis, with special reference to the ocular manifestations. South Med J 1941;34:165–170.

    CAS  Google Scholar 

  379. Rof Carballo J, Grande Covián F. Arriboflavinosis e invasión capilar de la córnea. Invasión capilar y su relación con el contenido en riboflavina de la dieta. Rev Clin Espan 1944;13:315–321.

    Google Scholar 

  380. Rof Carballo J, Grande Covean F. Arriboflavinosis e invasión capilar de la córnea. Pruebas terapéuticas. Rev Clin Espan 1944;13:380–387.

    Google Scholar 

  381. Bassi G, Jona S. Sulle manifestazioni oculari dell’alattoflavinosi umana. Boll d’Ocul 1945;24:3–18.

    Google Scholar 

  382. Stern HJ. Acute ocular manifestations of ariboflavinosis. Ophthalmologica 1947;114:103–106.

    Google Scholar 

  383. Jackson CRS. Riboflavin deficiency with ocular signs: report of a case. Br J Ophthalmol 1950;34:259–260.

    CAS  Google Scholar 

  384. Bellomio S. Contributo clinico alla conoscenza della alattoflavinosi oculare. Boll Ocul 1955;34:157–170.

    CAS  Google Scholar 

  385. Raymond LF. Reversible chronic recurrent keratitis with vascularization due to ariboflavinosis. J Med Soc New Jersey 1955;52:315–316.

    CAS  Google Scholar 

  386. Lundh B, Frandsen H. Riboflavin and ariboflavinosis, with special reference to eye changes. Acta Ophthalmol 1941;19:331–345.

    CAS  Google Scholar 

  387. Spies TD, Perry DJ, Cogswell RC, Frommeyer WB. Ocular disturbances in riboflavin deficiency. J Lab Clin Med 1945;30:751–765.

    Google Scholar 

  388. Chen TT. Angular blepharitis in ariboflavinosis—a not well known clinical manifestation of riboflavin deficiency. Chinese Med J 1948;66:1–4.

    Google Scholar 

  389. Stern JJ. The ocular manifestations of riboflavin deficiency. Am J Ophthalmol 1950;33:1127–1136.

    CAS  Google Scholar 

  390. Aykroyd WR, Verma OP. Superficial keratitis due to riboflavin deficiency. Indian Med Gaz 1942;77:1–5.

    Google Scholar 

  391. Verma OP. Further experience in the treatment of superficial keratitis with riboflavin. Indian Med Gaz 1942;77:471–472.

    Google Scholar 

  392. Gregory MK. The ocular criteria of deficiency of riboflavin. Br Med J 1943;2:134–135.

    Google Scholar 

  393. Vail D, Ascher KW. Corneal-vascularization problems. Am J Ophthalmol 1943;26:1025–1044.

    Google Scholar 

  394. Mann I. Ariboflavinosis. Am J Ophthalmol 1945;28:243–247.

    Google Scholar 

  395. Scarborough H. Circumcorneal injection as a sign of riboflavin deficiency in man, with an account of three cases of ariboflavinosis. Br Med J 1942;2:601–604.

    Google Scholar 

  396. Sandstead HR. Superficial vascularization of the cornea. The result of riboflavin therapy. Pub Health Rep 1942;57:1821–1825.

    Google Scholar 

  397. Youmans JB, Patton EW, Robinson WD, Kern R. An analysis of corneal vascularization as found in a survey of nutrition. Tran Assoc Am Physicians 1942;57:49–54.

    Google Scholar 

  398. Tisdall FF, McCreary JF, Pearce H. The effect of riboflavin on corneal vascularization and symptoms of eye fatigue in R.C.A.F. personnel. Canad Med Assoc J 1943;49:5–13.

    Google Scholar 

  399. Lyle TK, Macrae TF, Gardiner PA. Corneal vascularisation in nutritional deficiency. Lancet 1944;1:393–395.

    Google Scholar 

  400. Borsook H, Alpert E, Keighley GL. Nutritional status of aircraft workers in southern California. II. Clinical and laboratory findings. Milbank Mem Fund Quart Bull 1943;21:115–157.

    CAS  Google Scholar 

  401. Scott JG. Corneal vascularity as a sign of ariboflavinosis. J Roy Army Med Corps 1944;82:133–135.

    Google Scholar 

  402. Kodicek JH, Yudkin J. Slit-lamp microscope in nutrition surveys. Lancet 1942;2:753–756.

    Google Scholar 

  403. Venkataswamy G. Ocular manifestations of vitamin B-complex deficiency. Br J Ophthalmol 1967;51:749–754.

    CAS  Google Scholar 

  404. Hou HC. Riboflavin deficiency among Chinese. I. Ocular manifestations. Chinese Med J 1940;58:616–628.

    CAS  Google Scholar 

  405. Stern HJ. Conditioned corneal vascularity in riboflavin deficiency: report of a case. Arch Ophthalmol 1949;42:438–442.

    CAS  Google Scholar 

  406. Landau J, Stern HJ. Flare-up of trachomatous pannus due to ariboflavinosis. Am J Ophthalmol 1948;31:952–954.

    Google Scholar 

  407. Takami Y, Gong H, Amemiya T. Riboflavin deficiency induces ocular surface damage. Ophthalmic Res 2004;36:156–165.

    CAS  Google Scholar 

  408. Wagener HP. Nutritional diseases and the eye. The rôle of vitamin B. Am J Med Sci 1936;192:296–300.

    Google Scholar 

  409. Johnson LV, Eckardt RE. Rosacea keratitis and conditions with vascularization of cornea treated with riboflavin. Arch Ophthalmol 1940;23:899–907.

    Google Scholar 

  410. Cosgrove KW, Day PL. The use of riboflavin in the treatment of corneal diseases. Am J Ophthalmol 1942;25:544–551.

    Google Scholar 

  411. Fish WM. Acne rosacea keratitis and riboflavine (vitamin B2). Br J Ophthalmol 1943;27:107–109.

    Google Scholar 

  412. Pirie A. The relation of riboflavin to the eye. A review article. Br J Ophthalmol 1943;27:291–301.

    CAS  Google Scholar 

  413. Stern HJ, Landau J. Eczematous keratitis and ariboflavinosis. Am J Ophthalmol 1948;31:1619–1623.

    Google Scholar 

  414. Corkey JA. Riboflavin in marginal keratitis. Trans Ophthalmol Soc UK 1952;72:291–303.

    CAS  Google Scholar 

  415. Machella TE, McDonald PR. Studies of the B vitamins in the human subject. VI. Failure of riboflavin therapy in patients with the accepted picture of riboflavin deficiency. Am J Med Sci 1943;205:214–223.

    CAS  Google Scholar 

  416. Day PL, Langston WC, O’Brien CS. Cataract and other ocular changes in vitamin G deficiency: an experimental study on albino rats. Am J Ophthalmol 1931;14:1005–1009.

    CAS  Google Scholar 

  417. Bessey OA, Wolbach SB. Vascularization of the cornea of the rat in riboflavin deficiency, with a note on corneal vascularization in vitamin A deficiency. J Exp Med 1939;69:1–12.

    CAS  Google Scholar 

  418. Cochran W, DeVaughn NM, Allen L. Corneal vascularization in ariboflavinosis. South Med J 1942;35:888–889.

    Google Scholar 

  419. Wiesinger H, Kaunitz H, Slanetz CA. Hornhautveränderungen bei Ratten im Riboflavinomangel. Ophthal-mologica 1955;129:389–395.

    CAS  Google Scholar 

  420. Fromer CH, Klintworth GK. An evaluation of the role of leukocytes in the pathogenesis of experimentally induced corneal vascularization. Am J Pathol 1975;79:537–550.

    CAS  Google Scholar 

  421. Lowry OH, Bessey OA. The effects of light, trauma, riboflavin, and ariboflavinosis on the production of corneal vascularity and on healing of corneal lesions. J Nutr 1945;30:285–292.

    CAS  Google Scholar 

  422. Williams RD, Mason HL, Cusick PL, Wilder RM. Observations on induced riboflavin deficiency and the riboflavin requirement of man. J Nutr 1943;25:361–377.

    CAS  Google Scholar 

  423. Keys A, Henschel A, Taylor HL, Mickelsen O, Brozek J. Experimental studies on man with a restricted intake of the B vitamins. Am J Physiol 1945;144:5–45.

    CAS  Google Scholar 

  424. Boehrer JJ, Stanford CE, Ryan E. Experimental riboflavin deficiency in man. Am J Med Sci 1943;205:544–549.

    CAS  Google Scholar 

  425. Sebrell WH, Butler RE, Wooley JG, Isbell H. Human riboflavin requirement established by urinary excretion of subjects on controlled intake. Pub Health Report 1941;56:510–519.

    CAS  Google Scholar 

  426. Lane M, Mengel CE, Doherty DJ. Rapid induction of isolated riboflavin deficiency in man. J Clin Invest 1960;39:1004.

    Google Scholar 

  427. Lane M, Alfrey CP, Mengel CE, Doherty MA, Doherty J. The rapid induction of human riboflavin deficiency with galactoflavin. J Clin Invest 1964;43:357–373.

    CAS  Google Scholar 

  428. Lane M, Brindley CO. Laboratory and clinical studies with the riboflavin antagonist, galactoflavin. Proc Soc Exp Biol Med 1964;116:57–61.

    CAS  Google Scholar 

  429. Gordon OE. Riboflavin and the cornea. Quart Bull Northwestern Univ Med School 1952;26:120–123.

    CAS  Google Scholar 

  430. Langston WC, Day PL, Cosgrove KW. Cataract in the albino mouse resulting from a deficiency of vitamin G (B2). Arch Ophthalmol 1933;10:508–514.

    CAS  Google Scholar 

  431. Day PL, Langston WC. Further experiments with cataract in albino rats resulting from the withdrawal of vitamin G (B2) from the diet. J Nutr 1934;7:97–106.

    CAS  Google Scholar 

  432. O’Brien CS. Experimental cataract in vitamin G deficiency. Arch Ophthalmol 1932;8:880–887.

    CAS  Google Scholar 

  433. Yudkin AM. Ocular disturbances produced in experimental animals by dietary changes: clinical implications. J Am Med Assoc 1933;101:921–926.

    CAS  Google Scholar 

  434. Langston WC, Day PL. Nutritional cataract in the Norway rat (Mus norvegicus). South Med J 1933;26:128–129.

    CAS  Google Scholar 

  435. Langston WC, Day PL. The arrest of nutritional cataract in the albino rat by the use of vitamin G (B2). South Med J 1934;27:170–176.

    Google Scholar 

  436. Day PL, Darby WJ, Langston WC. The identity of flavin with the cataract-preventive factor. J Nutr 1937;13:389–399.

    CAS  Google Scholar 

  437. Eckhardt RE, Johnson LV. Nutritional cataract and relation of galactose to the appearance of senile suture line in rats. Arch Ophthalmol 1939;21:315–327.

    Google Scholar 

  438. Baum HM, Michaelree JF, Brown EB. The quantitative relationship of riboflavin to cataract formation in rats. Science 1942;95:24–25.

    CAS  Google Scholar 

  439. Bowles LL, Allen L, Sydenstricker VP, Hock CW, Hall WK. The development and demonstration of corneal vascularization in rats deficient in vitamin A and in riboflavin. J Nutr 1946;32:19–31.

    CAS  Google Scholar 

  440. Kaunitz H, Wiesinger H, Blodi FC, Johnson RE, Slanetz CA. Relation of protein and fat intake to growth and corneal vascularization in galactoflavin-produced ariboflavinosis. J Nutr 1954;52:467–482.

    CAS  Google Scholar 

  441. Srivastava SK, Beutler E. Increased susceptibility of riboflavin deficient rats to galactose cataract. Experientia 1970;26:250.

    CAS  Google Scholar 

  442. Gershoff SN, Andrus SB, Hegsted DM. The effect of the carbohydrate and fat content of the diet upon the riboflavin requirement of the cat. J Nutr 1959;68:75–88.

    CAS  Google Scholar 

  443. Street HR, Cowgill GR, Zimmerman HM. Further observations of riboflavin deficiency in the dog. J Nutr 1941;22:7–24.

    CAS  Google Scholar 

  444. Wintrobe MM, Buschke W, Follis RH Jr, Humphreys S. Riboflavin deficiency in swine, with special reference to the occurrence of cataracts. Bull Johns Hopkins Hosp 1944;75:102–114.

    CAS  Google Scholar 

  445. Derkac V. Zur medikamentösen Behandlung des Altersstars. Klin Monatsbl Augenheilk 1938;100:236–243.

    Google Scholar 

  446. Wagner H, Richner H, Karbacher P. Vorläufiges Ergebnis der Therapie des Altersstars mit Vitamin B2 (Lactoflavin)-Verabreichung: Kontrolle mit Spaltlampenmikroskopie. Klin Monatsbl Augenheilk 1938;101:543–557.

    Google Scholar 

  447. Batey DW, Eckhert CD. Analysis of flavins in ocular tissues of the rabbit. Invest Ophthalmol Vis Sci 1991;32:1981–1975.

    CAS  Google Scholar 

  448. Batey DW, Daneshgar KK, Eckhert CD. Flavin levels in the rat retina. Exp Eye Res 1992;54:605–609.

    CAS  Google Scholar 

  449. Bhat KS. Alterations in the lenticular proteins of rats on riboflavin deficient diet. Curr Eye Res 1982–1983;2:829–834.

    Google Scholar 

  450. Srivastava SK, Beutler E. Galactose cataract in riboflavin deficient rats. Biochem Med 1972;6:372–379.

    CAS  Google Scholar 

  451. Dutta P, Rivlin RS, Pinto J. Enhanced depletion of lens reduced glutathione by administration of adriamycin? in riboflavin-deficient rats. Biochem Pharmacol 1990;40:1111–1115.

    CAS  Google Scholar 

  452. Bates CJ. Glutathione and related indices in rats lenses, liver and red cells during riboflavin deficiency and its correction. Exp Eye Res 1991;53:123–130.

    CAS  Google Scholar 

  453. Sperduto RD, Hu TS, Milton RC, et al. The Linxian cataract studies. Two nutrition intervention trials. Arch Ophthalmol 1993;111:1246–1253.

    CAS  Google Scholar 

  454. Jacques PF, Taylor A, Moeller S, et al. Long-term nutrient intake and 5-year change in nuclear lens opacities. Arch Ophthalmol 2005;123:517–526.

    Google Scholar 

  455. McKinley MC. Nutritional aspects and possible pathological mechanisms of hyperhomocysteinaemia: an independent risk factor for vascular disease. Proc Nutr Soc 2000;59:221–237.

    CAS  Google Scholar 

  456. Hoogeveen EK, Kostense PJ, Eysink PE, et al. Hyperhomocysteinemia is associated with the presence of retinopathy in type 2 diabetes mellitus: the Hoorn study. Arch Intern Med 2000;160:2984–2990.

    CAS  Google Scholar 

  457. Vaccaro O, Perna AF, Mancini FP, et al. Plasma homocysteine and microvascular complications in type 1 diabetes. Nutr Metab Cardiovasc Dis 2000;10:297–304.

    CAS  Google Scholar 

  458. Reddi AS, Frank O, Baker H. Riboflavin excretion in normal and diabetic rats. Int J Vitam Nutr Res 1990;60:252–254.

    CAS  Google Scholar 

  459. Reddi AS, Jyothirmayi GN, DeAngelis B, Frank O, Baker H. Tissue concentrations of water-soluble vitamins in normal and diabetic rats. Int J Vitam Nutr Res 1993;63:140–144.

    CAS  Google Scholar 

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(2007). Nutritional Amblyopia and B Complex Vitamin Deficiencies. In: Handbook of Nutrition and Ophthalmology. Nutrition and Health. Humana Press. https://doi.org/10.1007/978-1-59259-979-0_7

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