Fundamentals of Cancer Treatment
Cytotoxic chemotherapy evolved from the concepts of Lissauer and Ehrlich over the last century. The initial chemotherapy protocols they devised were characterized by a lack of specificity, and walking a fine line balancing the toxicities experienced by the host and the tumor. This has been subsequently improved owing to a better understanding of tumor biology and the biochemical basis of action of the chemotherapy regimens. Radiation therapy started after the discovery of X-rays by Roentgen in 1895. Refinement of these modalities has resulted in therapeutic options for patients with several types of malignancies. Innovative modern techniques in the 1990s have provided insight into the intracellular pathways that result in sensitivity and resistance of the neoplastic cells to drug treatment.
KeywordsVascular Endothelial Growth Factor Chronic Lymphocytic Leukemia Polycythemia Vera Antineoplastic Agent Vinca Alkaloid
Unable to display preview. Download preview PDF.
- 4.Yankee RA, De Vita VT, Perry S. The cell cycle of leukemia L 1210 cells in vivo. Cancer Res 1968; 27:2381–2385.Google Scholar
- 16.Steel GG, Adams GE, Peckham MJ, eds. The Biologic Basis of Radiotherapy. The Netherlands: Elsevier; 1983:239–248.Google Scholar
- 29.DeVita VT, Schein PS. The use of drugs in combination for the treatment of cancer: rationale and results. N Engl J Med 1973; 228:998–1006.Google Scholar
- 30.Skipper HE. Critical variables in the design of combination chemotherapy regimens to be used alone or in adjuvant settings. Colloque INSERM 1986; 137:11.Google Scholar
- 31.Hyrniuk WM. Average relative dose intensity and the impact on design of clinical trials. Semin Oncol 1987:14:65–74.Google Scholar
- 36.Rideout DC, Chou TC. Synergism, potentiation and antagonism in chemotherapy. An overview. In: Chou TC, Rideout DC, eds. Synergism and Antagonism in Chemotherapy. San Diego, CA: Academic Press; 1991:3.Google Scholar
- 40.Perry MC, ed. The Chemotherapy Sourcebook. 3rd ed. Philadelphia, PA: Lippincott, Williams and Wilkins; 2001.Google Scholar