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Tumor Behavior

Barriers to Growth and Spread

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Cancer in the Spine

Part of the book series: Current Clinical Oncology ((CCO))

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Abstract

Tumors arising in the vertebral body itself pose little danger to health and survival until they find a way into the larger system and either successfully metastasize or grow to a large enough size to threaten local vital organs. The barriers that must be overcome start with the basement membrane in either circumstance. Thereafter, the tumor must either demonstrate the ability to cross the vascular wall of the local capillary bed, survive in the circulation, and successfully implant elsewhere or the tumor must be able to overcome the local, physical barriers of the trabecular bone and cortical shell of the vertebra itself, the periosteum and overlying ligaments of the spinal column, and, finally, the muscular sheath with its many fascial layers and apposed parietal pleura.

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© 2006 Humana Press, Inc., Totowa, NJ

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McLain, R.F. (2006). Tumor Behavior. In: McLain, R.F., Lewandrowski, KU., Markman, M., Bukowski, R.M., Macklis, R., Benzel, E.C. (eds) Cancer in the Spine. Current Clinical Oncology. Humana Press. https://doi.org/10.1007/978-1-59259-971-4_4

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  • DOI: https://doi.org/10.1007/978-1-59259-971-4_4

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-074-8

  • Online ISBN: 978-1-59259-971-4

  • eBook Packages: MedicineMedicine (R0)

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