Advertisement

Tumor Behavior

Barriers to Growth and Spread
  • Robert F. McLain
Part of the Current Clinical Oncology book series (CCO)

Abstract

Tumors arising in the vertebral body itself pose little danger to health and survival until they find a way into the larger system and either successfully metastasize or grow to a large enough size to threaten local vital organs. The barriers that must be overcome start with the basement membrane in either circumstance. Thereafter, the tumor must either demonstrate the ability to cross the vascular wall of the local capillary bed, survive in the circulation, and successfully implant elsewhere or the tumor must be able to overcome the local, physical barriers of the trabecular bone and cortical shell of the vertebra itself, the periosteum and overlying ligaments of the spinal column, and, finally, the muscular sheath with its many fascial layers and apposed parietal pleura.

Keywords

Vertebral Body Direct Extension Adjacent Vertebra Type Versus Collagen Cortical Shell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Carrel A, Burrows MT. Cultivation in vitro of malignant tumors. J Exp Med 1911; 13:571–575.CrossRefGoogle Scholar
  2. 2.
    Stossel TP. On the crawling of animal cells. Science 1993; 260:1086–1094.PubMedCrossRefGoogle Scholar
  3. 3.
    Batson OV. The role of the vertebral veins in metastatic processes. Ann Intern Med 1942; 16:38–58.Google Scholar
  4. 4.
    Harrington KD. Metastatic disease of the spine. In: KD Harrington ed. Orthopaedic Management of Metastatic Bone Disease. St. Louis, MO: CV Moseby; 1988.Google Scholar
  5. 5.
    Weiss L. Metastasis of cancer: a conceptual history from antiquity to the 1990s. Cancer and Metastasis Rev 2000; 19:257–279.CrossRefGoogle Scholar
  6. 6.
    Kuettner KE, Pauli BU. Resistance of cartilage to invasion. In: L Weiss, Gilbert HA, eds. Bone Metastasis. Boston MA: GK Hall; 1981.Google Scholar
  7. 7.
    Seiki M, Koshikawa N, Yana I. Role of pericellular proteolysis by membrane-type 1 matrix metalloproteinase in cancer invasion and angiogenesis. Cancer and Metastasis Rev 2003; 22:129–143.CrossRefGoogle Scholar
  8. 8.
    Kleiner DE, Stetler-Stevenson WG. Matrix metalloproteinases and metastasis. Cancer Chemother Pharmacol 1999; 43:S42.PubMedCrossRefGoogle Scholar
  9. 9.
    Kajita M, Itoh Y, Chiba T, et al. Membrane type-1 matrix metalloproteinase cleaves CD44 and promotes cell migration. J Cell Biol 2001; 153:893–904.PubMedCrossRefGoogle Scholar
  10. 10.
    Mignatti P, Rifkin DB. Biology and biochemistry of proteinases in tumor invasion. Physiol Rev 1993; 73:161–195.PubMedGoogle Scholar
  11. 11.
    Sato H, Takino T, Okada Y, et al. A matrix metalloproteinase expressed on the surface of invasive tumor cells. Nature 1994; 370:61–65.PubMedCrossRefGoogle Scholar
  12. 12.
    Zucker S, Vacirca J. Role of matrix metalloproteinases (MMPs) in colorectal cancer. Cancer and Metastasis Rev 2003; 23:101–117.CrossRefGoogle Scholar
  13. 13.
    Nagase H, Woessner JF. Matrix metalloproteinases. J Biol Chem 1999; 274:21,491–21,494.PubMedCrossRefGoogle Scholar
  14. 14.
    Gianelli G, Falk-Marzillier J, Schiraldi O, Stetler-Stevenson WG, Quaranta V. Induction of cell migration by matrix metalloproteinase-2 cleavage of laminin-5. Science 1997; 277:225–228.CrossRefGoogle Scholar
  15. 15.
    Koshikawa N, Gianelli G, Cirulli V, Miyazaki K, Quaranta V. Role of cell surface metalloproteinase MTI-MMP in epithelial cell migration over laminin-5. J Cell Biol 2000; 148:615.PubMedCrossRefGoogle Scholar
  16. 16.
    Chambers AF, Matrisian LM. Changing views of the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst 1997; 89: 1260–1270.PubMedCrossRefGoogle Scholar
  17. 17.
    Gumbiner BM. Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell 1996; 84:345–358.PubMedCrossRefGoogle Scholar
  18. 18.
    Lauffenburger DA, Horwitz AF. Cell migration: a physically integrated molecular process. Cell 1996; 84:359–369.PubMedCrossRefGoogle Scholar
  19. 19.
    Mitchson TJ, Cramer LP. Actin-based cell motility and cell locomotion. Cell 1996; 84:371–379.CrossRefGoogle Scholar
  20. 20.
    Choquet D, Felsenfeld DP, Sheetz MP. Extracellular matrix rigidity causes strengthening of integrin-cytoskeleton linkages. Cell 1997; 88:39–48.PubMedCrossRefGoogle Scholar
  21. 21.
    Sheetz MP, Felsenfeld DP, Galbraith CG. Cell migration: regulation of force on extracellular-matrix-integrin complexes. Trends Cell Biol 1998; 8:51–54.PubMedCrossRefGoogle Scholar
  22. 22.
    Niinaka Y, Paku S, Haga A, Watanabe H, Raz A. Expression and secretion of neuroleukin/phosphohexose isomerase/maturation factor as autocrine motility factor by tumor cells. Cancer Res 1998; 58:2667–2674.PubMedGoogle Scholar

Copyright information

© Humana Press, Inc., Totowa, NJ 2006

Authors and Affiliations

  • Robert F. McLain
    • 1
  1. 1.Lerner College of Medicine and The Cleveland Clinic Spine Institute, Department of Orthopaedic SurgeryThe Cleveland Clinic FoundationCleveland

Personalised recommendations