Tumor Behavior

Barriers to Growth and Spread
  • Robert F. McLain
Part of the Current Clinical Oncology book series (CCO)


Tumors arising in the vertebral body itself pose little danger to health and survival until they find a way into the larger system and either successfully metastasize or grow to a large enough size to threaten local vital organs. The barriers that must be overcome start with the basement membrane in either circumstance. Thereafter, the tumor must either demonstrate the ability to cross the vascular wall of the local capillary bed, survive in the circulation, and successfully implant elsewhere or the tumor must be able to overcome the local, physical barriers of the trabecular bone and cortical shell of the vertebra itself, the periosteum and overlying ligaments of the spinal column, and, finally, the muscular sheath with its many fascial layers and apposed parietal pleura.


Vertebral Body Direct Extension Adjacent Vertebra Type Versus Collagen Cortical Shell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Humana Press, Inc., Totowa, NJ 2006

Authors and Affiliations

  • Robert F. McLain
    • 1
  1. 1.Lerner College of Medicine and The Cleveland Clinic Spine Institute, Department of Orthopaedic SurgeryThe Cleveland Clinic FoundationCleveland

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