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Conformal Radiotherapy for Spinal Lesions

  • Richard L. Crownover
Part of the Current Clinical Oncology book series (CCO)

Abstract

In the spine, as elsewhere, conventional doses and treatment schedules in radiotherapy have been titrated to the clinical tolerance of normal tissues. Protracted treatment courses delivered over several weeks, “fractionated schedules,” are a radiobiological compromise employed to permit normal tissue repair between multiple small doses of radiation with the goal of reducing morbid late effects of treatment. Radiotherapy is widely used because this approach is often successful in dealing with microscopic disease or particularly radio-sensitive tumors, however, for bulky disease or radio-resistant tumors, sterilizing tumoricidal doses may never be reached owing to limitations imposed by nearby critical structures such as the spinal cord.

Keywords

Spinal Canal Radiat Oncol Biol Phys Conformal Radiotherapy Glomus Tumor Spinal Lesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Fowler JF. The linear-quadratic formula and progress in fractionated radiotherapy. Br J Radiol 1989; 62:679–694.PubMedGoogle Scholar
  2. 2.
    Gutin PH, Leibel SA, Hosobuchi Y, et al. Brachytherapy of recurrent tumors of the skull base and spine with iodine-125 sources. Neurosurgery 1987; 20:938–945.PubMedCrossRefGoogle Scholar
  3. 3.
    Hamilton AJ, Lulu B, Baldassarre S, Wai CC, Cassady RJ. The use of gold foil wrapping for radiation protection of the spinal cord for recurrent tumor therapy. Int J Radiat Oncol Biol Phys 1995; 32:507–511.PubMedCrossRefGoogle Scholar
  4. 4.
    Rogers L, Theodore N, Dickman C, et al. Surgery and permanent I-125 seed paraspinal brachytherapy for malignant rumors with spinal cord compression. Int J Radiat Oncol Biol Phys 2002; 54;503–513.Google Scholar
  5. 5.
    Lohr F, Debus J, Frank C, et al. Noninvasive patient fixation for extracranial stereotactic radiotherapy. Int J Radiat Oncol Biol Phys 1999; 45:521–527.PubMedGoogle Scholar
  6. 6.
    Hamilton AJ, Lulu BA, Fosmire H, Stea B, Cassady JR. Preliminary clinical experience with linear accelerator-based spinal stereotactic radiosurgery. Neurosurgery 1995; 36:311–319.PubMedCrossRefGoogle Scholar
  7. 7.
    Hamilton AJ, Lulu BA, Fosmire H, Gossett L. LINAC-based spinal stereotactic radiosurgery. Stereotact Funct Neurosurg 1996; 66:1–9.PubMedCrossRefGoogle Scholar
  8. 8.
    Ryu, SI, Chang SD, Kim DH, et al. Image-guided hypo-fractionated stereotactic radiosurgery to spinal lesions. Neurosurgery 2000; 49:838–846.CrossRefGoogle Scholar
  9. 9.
    Hug EB, Fitzek MM, Liebsch NJ, Munzenrider JE. Locally challenging osteo-and chondrogenic tumors of the axial skeleton: results of combined proton and photon radiation therapy using three-dimensional treatment planning. Int J Radiat Oncol Biol Phys 1995; 31:467–476.PubMedGoogle Scholar
  10. 10.
    Hug EB, Laredo LN, Slater JD, et al. Proton radiation therapy for chordomas and chondrosarcomas of the skull base. J Neurosurg 1999; 91:432–439.PubMedCrossRefGoogle Scholar

Copyright information

© Humana Press, Inc., Totowa, NJ 2006

Authors and Affiliations

  • Richard L. Crownover
    • 1
  1. 1.The Reading Hospital Regional Cancer CenterWest Reading

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