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Lymphoma

  • Ronald M. Sobecks
Part of the Current Clinical Oncology book series (CCO)

Abstract

In the year 2002 there was an estimated 60,900 new cases of lymphoma in the United States, with 53,900 cases of non-Hodgkin’s lymphoma (NHL) and 7000 cases of Hodgkin’s lymphoma (1). Estimated deaths in 2002 for NHL and Hodgkin’s lymphoma were 24,400 and 1400, respectively. The male to female ratio for both NHL and Hodgkin’s lymphoma is presently 1.1:1. Although the incidence of Hodgkin’s lymphoma has remained stable over the past several decades, there has been an increasing incidence of NHL in North America at a rate of approx 2 to 3% per year. NHL comprises 4% of male and female cancers in the United States, being the fifth most common malignancy among women (after breast, lung, colorectal, and uterine) and the sixth most common among men (after prostate, lung, colorectal, urinary bladder, and melanoma) (1).

Keywords

Clin Oncol International Prognostic Index Anaplastic Large Cell Lymphoma Splenic Marginal Zone Lymphoma Prolymphocytic Leukemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Jemal A, Thomas A, Murray T, Thun M. Cancer Statistics, 2002. CA Cancer J Clin 2002;52:23–47.PubMedGoogle Scholar
  2. 2.
    Stein H, Delsol G, Pileri S, et al. Hodgkin lymphoma. In: Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. World Health Organization Classification of Tumours. Pathology and Genetics. Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press; 2001:238–253.Google Scholar
  3. 3.
    Harris NL, Müller-Hermelink HK, Catovsky D, et al. Mature B-cell neoplasms. In: Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. World Health Organization Classification of Tumours. Pathology and Genetics. Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press; 2001:119–235.Google Scholar
  4. 4.
    Armitage JO, Mauch PM, Harris NL, Bierman P. Non-Hodgkin’s lymphomas. In: Devita VT, Hellman S, Rosenberg SA, eds. Cancer: Principles and Practice of Oncology. 6th ed. Philadelphia, PA: Lippincott Williams and Wilkins; 2001:2258–2260.Google Scholar
  5. 5.
    Cleary ML, Smith SD, Sklar J. Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2 /immunoglobulin transcript resulting from the t(14;18) translocation. Cell 1986;47:19–28.PubMedCrossRefGoogle Scholar
  6. 6.
    Pinkus GS. Needle biopsy in malignant lymphoma. J Clin Oncol 1996;4:2415–2416.Google Scholar
  7. 7.
    Lister TA, Crowther D, Sutcliffe SB, et al. Report of a committee convened to discuss the evaluation and staging of patients with Hodgkin’s disease: Cotswolds meeting. J Clin Oncol 1989;7:1630–1636.PubMedGoogle Scholar
  8. 8.
    Carbone PP, Kaplan HS, Musshoff K, Smithers DW, Tubiana M. Report of the Committee on Hodgkin’s Disease Staging Classification. Cancer Res 1971;31:1860–1861.PubMedGoogle Scholar
  9. 9.
    Hasenclever D, Diehl V. A prognostic score for advanced Hodgkin’s disease. International Prognostic Factors Project on Advanced Hodgkin’s disease. N Engl J Med 1998;339:1506–1514.PubMedCrossRefGoogle Scholar
  10. 10.
    The International Non-Hodgkin’s Lymphoma Prognostic Factors Project. A predictive model for aggressive non-Hodgkin’s lymphoma. N Engl J Med 1993;329:987–994.CrossRefGoogle Scholar
  11. 11.
    Santoro A, Bonfante V, Viviani S, et al. Subtotal nodal (STNI) vs. involved field (IFRT) irradiation after 4 cycles of ABVD in early stage Hodgkin’s disease (HD). Proc Am Soc Clin Oncol 1996;15:415.Google Scholar
  12. 12.
    Klasa RJ, Connors JM, Fairey R, et al. Treatment of early stage Hodgkin’s disease: Improved outcome with brief chemotherapy and radiotherapy without staging laparotomy. Annal Oncol 1996;7:21.Google Scholar
  13. 13.
    Horning SJ, Hoppe RT, Mason J, et al. Stanford-Kaiser Permanente GI study for clinical stage I and IIA Hodgkin’s disease: subtotal lymphoid irradiation versus vinblastine, methotrexate, and bleomycin chemotherapy and regional irradiation. J Clin Oncol 1997;15:1736–1744.PubMedGoogle Scholar
  14. 14.
    Canellos GP, Anderson JR, Propert KJ, et al. Chemotherapy for advanced Hodgkin’s disease with MOPP, ABVD, or MOPP alternating with ABVD. N Engl J Med 1992;327:1478–1484.PubMedGoogle Scholar
  15. 15.
    Loeffler M, Brosteanu O, Hasenclever D, et al. Meta-analysis of chemotherapy versus combined modality treatment trials in Hodgkin’s disease. International Database on Hodgkin’s Disease Overview Study Group. J Clin Oncol 1998;16:818–829.PubMedGoogle Scholar
  16. 16.
    Bierman PJ, Anderson JR, Freeman MB, et al. High-dose chemotherapy followed by autologous hematopoietic rescue for Hodgkin’s disease patients following first relapse after chemotherapy. Ann Oncol 1996;7:151–156.PubMedGoogle Scholar
  17. 17.
    Reddy S, Saxena VS, Pellettiere EV, Hendrickson FR. Stage I and II non-Hodgkin’s lymphomas; long-term results of radiation therapy. Int J Radiat Oncol Biol Phys 1989;16:687–692.PubMedGoogle Scholar
  18. 18.
    Network NCC. NCCN preliminary non-Hodgkin’s lymphoma practice guidelines. Oncology 1997;11:28–46.Google Scholar
  19. 19.
    Horning SJ. Treatment approaches to the low-grade lymphomas. Blood 1994;83:881–884.PubMedGoogle Scholar
  20. 20.
    Kennedy BJ, Bloomfield CD, Kiang DT, Vosika G, Peterson BA, Theologides A. Combination versus successive single agent chemotherapy in lymphocytic lymphoma. Cancer 1978;41:23–28.PubMedCrossRefGoogle Scholar
  21. 21.
    Saven A, Lee T, Kosty M, Piro L. Cladribine and mitoxantrone dose escalation in indolent non-Hodgkin’s lymphoma. J Clin Oncol 1996;14:2139–2144.PubMedGoogle Scholar
  22. 22.
    McLaughlin P, Hagemeister FB, Romaguera JE, et al. Fludarabine, mitoxantrone, and dexamethasone: an effective new regimen for indolent lymphoma. J Clin Oncol 1996;14:1262–1268.PubMedGoogle Scholar
  23. 23.
    Solal-Celigny P, Lepage E, Brousse N, et al. Recombinant interferon alpha-2b combined with a regimen containing doxorubicin in patients with advanced follicular lymphoma. N Engl J Med 1993;329:1608–1614.PubMedCrossRefGoogle Scholar
  24. 24.
    McLaughlin P, Grillo-Lopez A, Link BK, et al. Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four dose treatment program. J Clin Oncol 1998;16:2825–2833.PubMedGoogle Scholar
  25. 25.
    Witzig TE, Flinn IW, Gordon LI, et al. Treatment with ibritumomab tiuxetan radioimmunotherapy in patients with rituximab-refractory follicular non-Hodgkin’s lymphoma. J Clin Oncol 2002;20:3262–3269PubMedCrossRefGoogle Scholar
  26. 26.
    Verdonck LF, Dekker AW, Lokhorst HM, Petersen EJ, Nieuwenhuis HK. Allogeneic versus autologous bone marrow transplantation for refractory and recurrent low-grade non-Hodgkin’s lymphoma. Blood 1997;90:4201–4205.PubMedGoogle Scholar
  27. 27.
    Chen MG, Prosnitz LR, Gonzalez-Serva A, Fischer DB. Results of radiotherapy in control of stage I and II non-Hodgkin’s lymphoma. Cancer 1979;43:1245–1254.PubMedCrossRefGoogle Scholar
  28. 28.
    Shenkier TN, Voss N, Fairey R, et al. Brief chemotherapy and involved-region irradiation for limited-stage diffuse large cell lymphoma: an 18-year experience from the British Columbia Cancer Agency. J Clin Oncol 2001;20:197–204.CrossRefGoogle Scholar
  29. 29.
    Horning SJ, Glick JH, Kim K, et al. Final report of E1484: CHOP v CHOP + Radiotherapy (RT) for limited stage diffuse aggressive lymphoma. Blood 2001;98:724a.Google Scholar
  30. 30.
    Fisher RI, Gaynor ER, Dahlberg S, et al. Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin’s lymphoma. N Engl J Med 1993;328:1002–1006.PubMedCrossRefGoogle Scholar
  31. 31.
    Coiffier B, Lepage E, Briere J, et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large B-cell lymphoma. N Engl J Med 2002;346:235–242.PubMedCrossRefGoogle Scholar
  32. 32.
    Haioun C, LePage E, Gisselbrecht C, et al. Benefit of autologous bone marrow transplantation over sequential chemotherapy in poorrisk aggressive non-Hodgkin’s lymphoma: updated results of the prospective study LNH87-2. Group d’Etude des Lymphomes de l’Adulte. J Clin Oncol 1997;15:1131–1137.PubMedGoogle Scholar
  33. 33.
    Velasquez WS, McLaughlin P, Tucker S, et al. ESHAP-an effective chemotherapy regimen in refractory and relapsing lymphoma: a 4 year follow-up study. J Clin Oncol 1994;12:1169–1176.PubMedGoogle Scholar
  34. 34.
    Moskowitz CH, Bertino JR, Glassman JR, et al. Ifosfamide, carboplatin, and etoposide: a highly effective cytoreduction and peripheral-blood progenitor-cell mobilization regimen for transplant-eligible patients with non-Hodgkin’s lymphoma. J Clin Oncol 1999;17:3776–3785.PubMedGoogle Scholar
  35. 35.
    Philip T, Guglielmi C, Hagenbeek A, et al. Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin’s lymphoma. N Engl J Med 1995;333:1540–1545.PubMedCrossRefGoogle Scholar
  36. 36.
    Magrath IT, Adde M, Shad A, et al. Adults and children with small non-cleaved cell lymphoma have a similar excellent outcome when treated with the same chemotherapy regimen. J Clin Oncol 1996;14:925–934.PubMedGoogle Scholar
  37. 37.
    Hoelzer D, Ludwig WD, Thiel E, et al. Improved outcome in adult B-cell acute lymphoblastic leukemia. Blood 1996;87:495–508.PubMedGoogle Scholar
  38. 38.
    Chade HO. Metastatic tumours of the spine and spinal cord. In: Vinkers PJ, Bruyn GW, eds. Handbook of Clinical Neurology. Vol 20. Amsterdam: North Holland; 1976:415–433.Google Scholar
  39. 39.
    Spagnoli I, Gattoni F, Viganotti G. Roentgenographic aspects of non-Hodgkin’s lymphomas presenting with osseous lesions. Skeletal Radiol 1982;8:39–41.PubMedCrossRefGoogle Scholar
  40. 40.
    Eustace S, O’Regan R, Graham D, Carney D. Primary multifocal skeletal Hodgkin’s disease confined to bone. Skeletal Radiol 1995;24:61–63.PubMedCrossRefGoogle Scholar
  41. 41.
    Salvati M, Cervoni L, Artico M, Raco A, Ciappetta P, Delfini R. Primary spinal epidural non-Hodgkin’s lymphomas: a clinical study. Surg Neurol 1996;46:339–343.PubMedCrossRefGoogle Scholar
  42. 42.
    Epelbaum R, Haim N, Ben-Shahar M, Ben-Arie Y, Feinsod M, Cohen Y. Non-Hodgkin’s lymphoma presenting with spinal epidural involvement. Cancer 1986;58:2120–2124.PubMedCrossRefGoogle Scholar
  43. 43.
    Lyons MK, O’Neill BP, Kurtin PJ, Marsh WR. Diagnosis and management of primary spinal epidural non-Hodgkin’s lymphoma. Mayo Clin Proc 1996;71:453–457.PubMedGoogle Scholar
  44. 44.
    Haddad P, Thaell JF, Kiely JF, et al. Lymphoma of the spinal epidural space. Cancer 1976;38:1862–1866.PubMedCrossRefGoogle Scholar
  45. 45.
    Oviatt DL, Kirshner HS, Stein RS. Successful chemotherapeutic treatment of epidural compression in non-Hodgkin’s lymphoma. Cancer 1982;49:2446–2448.PubMedCrossRefGoogle Scholar
  46. 46.
    Higgins SA, Peschel RE. Hodgkin’s disease with spinal cord compression. A case report and a review of the literature. Cancer 1995;75:94–98.PubMedCrossRefGoogle Scholar
  47. 47.
    Perry JR, Deodhare SS, Bilbao JM, Murray D, Muller P. The significance of spinal cord compression as the initial manifestation of lymphoma. Neurosurgery 1993;32:157–162.PubMedCrossRefGoogle Scholar
  48. 48.
    Slager UT, Kaufman RL, Cohen KL, Tuddenham WJ. Primary lymphoma of the spinal cord. J Neuropathol Exp Neurol 1982;41:437–445.PubMedCrossRefGoogle Scholar
  49. 49.
    Iizuka H, Nakamura T, Kato M. Malignant lymphoma of the spinal epidural space: report of three cases. Neurol Med Chir 1989;29:307–311.CrossRefGoogle Scholar
  50. 50.
    Pels H, Vogt I, Klockgether T, Schlegel U. Primary non-Hodgkin’s lymphoma of the spinal cord. Spine 2000;25:2262–2264.PubMedCrossRefGoogle Scholar
  51. 51.
    Barnard M, Perez-Ordonez B, Rowed DW, Ang LC. Primary spinal epidural mantle cell lymphoma: case report. Neurosurgery 2000;47:1239–1241.PubMedCrossRefGoogle Scholar
  52. 52.
    McDonald AC, Nicoll JA, Rampling RP. Non-Hodgkin’s lymphoma presenting with spinal cord compression; a clinicopathological review of 25 cases. Eur J Cancer 2000;36:207–213.PubMedCrossRefGoogle Scholar
  53. 53.
    Margulies JY, Kenan S, Michowitz SD, et al. Cord compression as the presenting symptom of extradural malignant lymphoma. Arch Orthop Trauma Surg 1987;106:291–296.PubMedCrossRefGoogle Scholar
  54. 54.
    Toner GC, Holmes R, Sinclair RA, Tang SK, Schwarz MA. Central nervous system lymphoma: primary lumbar nerve root infiltration. Acta Haematol 1989;81:44–47.PubMedGoogle Scholar
  55. 55.
    Maiuri F, Gangemi M, Giamundo A, Iaconetta G, De Chiara AR. Primary spinal epidural lymphomas. Acta Neurol (Napoli) 1988;10:213–219.Google Scholar
  56. 56.
    Mascalchi M, Torselli P, Falaschi F, Dal Pozzo G. MRI of spinal epidural lymphoma. Neuroradiology 1995;37:303–307.PubMedCrossRefGoogle Scholar
  57. 57.
    Mullins GM, Flynn JP, el-Mahdi AM, McQueen JD, Owens AH Jr. Malignant lymphoma of the spinal epidural space. Ann Intern Med 1971;74:416–423.PubMedGoogle Scholar
  58. 58.
    Russell DS, Rubinstein LJ. Pathology of Tumours of the Nervous System. 5th ed. Baltimore, MD: Williams and Wilkins; 1989:608–615.Google Scholar
  59. 59.
    Rao TV, Narayanaswamy KS, Shankar SK, Deshpande DH. “Primary” spinal epidural lymphomas: a clinico-pathological study. Acta Neurochir (Wien) 1982;62:307–317.CrossRefGoogle Scholar
  60. 60.
    Raco A, Cervoni L, Salvati M, Delfini R. Primary spinal epidural non-Hodgkin’s lymphomas in childhood: a review of 6 cases. Acta Neurochir (Wien) 1997;139:526–528.CrossRefGoogle Scholar
  61. 61.
    Wong ET, Portlock CS, O’Brien JP, DeAngelis LM. Chemosensitive epidural spinal cord disease in non-Hodgkins lymphoma. Neurology 1996;46:1543–1547.PubMedGoogle Scholar
  62. 62.
    Ron IG, Reider I, Wigler N, Chaitchik S. Primary spinal epidural non-Hodgkin’s lymphoma. The contribution of nuclear magnetic resonance imaging, therapeutic approach and review of the literature. Tumori 1992;78:397–402.PubMedGoogle Scholar
  63. 63.
    Mora J, Wollner N. Primary epidural non-Hodgkin lymphoma: Spinal cord compression syndrome as the initial form of presentation in childhood non-Hodgkin lymphoma. Med Pediatr Oncol 1999;32:102–105.PubMedCrossRefGoogle Scholar
  64. 64.
    Cappellani G, Giuffre F, Tropea R, et al. Primary spinal epidural lymphomas. Report of ten cases. J Neurosurg Sci 1986;30:147–151.PubMedGoogle Scholar
  65. 65.
    Laing RJ, Jakubowski J, Kunkler IH, Hancock BW. Primary spinal presentation of non-Hodgkin’s lymphoma. A reappraisal of management and prognosis. Spine 1992;17:117–120.PubMedCrossRefGoogle Scholar
  66. 66.
    Dimarco A, Campostrini F, Garusi GF. Non-Hodgkin’s lymphomas presenting with spinal epidural involvement. Acta Oncol 1989;28:485–488.CrossRefGoogle Scholar
  67. 67.
    Herbst KD, Corder MP, Justice GR. Successful therapy with methotrexate of a multicentric mixed lymphoma of the central nervous system. Cancer 1976;38:1476–1478.PubMedCrossRefGoogle Scholar
  68. 68.
    Mitsumoto H, Breuer AC, Lederman RJ. Malignant lymphoma of the central nervous system: a case of primary spinal intramedullary involvement. Cancer 1980;46:1258–1262.PubMedCrossRefGoogle Scholar
  69. 69.
    Hautzer NW, Aiyesimoju A, Robitaille Y. “Primary” spinal intramedullary lymphomas: a review. Ann Neurol 1983;14:62–66.PubMedCrossRefGoogle Scholar
  70. 70.
    Itami J, Mori S, Arimizu N, Inoue S, Lee M, Uno K. Primary intramedullary spinal cord lymphoma: report of a case. Jpn J Clin Oncol 1986;16:407–412.PubMedGoogle Scholar
  71. 71.
    Schild SE, Wharen RE Jr, Menke DM, Folger WN, Colon-Otero G. Primary lymphoma of the spinal cord. Mayo Clin Proc 1995;70:256–260.PubMedGoogle Scholar
  72. 72.
    Lim CC, Chong BK. Spinal epidural non-Hodgkin’s lymphoma: case reports of three patients presenting with spinal cord compression. Singapore Med J 1996;37:497–500.PubMedGoogle Scholar
  73. 73.
    Citow JS, Rini B, Wollmann R, Macdonald RL. Isolated, primary extranodal Hodgkin’s disease of the spine: case report. Neurosurgery 2001;49:453–456.PubMedCrossRefGoogle Scholar
  74. 74.
    Moridaira K, Handa H, Murakami H, et al. Primary Hodgkin’s disease of the bone presenting with an extradural tumor. Acta Haematol 1994;92:148–149.PubMedCrossRefGoogle Scholar

Copyright information

© Humana Press, Inc., Totowa, NJ 2006

Authors and Affiliations

  • Ronald M. Sobecks
    • 1
  1. 1.Department of Hematology and OncologyThe Cleveland Clinic FoundationClevelandOH

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