Multiple Myeloma and Plasmacytoma
Multiple myeloma (MM) is a clonal disorder of B-cell lymphocytic lineage characterized by malignant transformation of plasma cells. It accounts for approx 10% of all the hematological malignancies and 1% of all cancers in the United States. In the year 2000, MM was diagnosed in approx 13,700 people in the United States and accounted for 20% of deaths from hematological malignancies (1). The median age of onset is 68 yr. It is slightly more frequent in women and the incidence in African-Americans is twice that of Whites. Both the overall incidence and specifically the incidence in African-Americans have been rising in recent years. A recent study explored whether dietary factors contribute to the risk of MM and the twofold higher incidence among Blacks compared with Whites in the United States. Data from a food frequency questionnaire were analyzed for 346 White and 193 Black subjects with MM, and 1086 White and 903 Black controls who participated in a population-based case-control study of MM in three areas of the United States. This study concluded that the greater use of vitamin C supplements by Whites and the higher frequency of obesity among Blacks may explain part of the higher incidence of MM among Blacks compared to Whites in the United States.
KeywordsMultiple Myeloma Clin Oncol Bone Marrow Stromal Cell Monoclonal Protein Poem Syndrome
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