Abstract
Understanding of the molecular basis of asthma has progressed significantly in the last decade. The roles of immune recognition and effector cells in orchestrating airway inflammation have been developed, and a picture of how these cells—as well as structural cells within the airways—control long-term tissue remodeling is emerging, which provides a comprehensive view of the pathophysiological processes involved in the disease. Phenotypic changes in the asthmatic bronchial epithelium, and its interaction with other cells, have been identified which explain many features of asthma. Moreover, major steps have been taken in characterizing the genetic basis of the disease.
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© 2006 Humana Press Inc.
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Holgate, S.T., Dent, G., Buckley, M.G. (2006). Asthma. In: Runge, M.S., Patterson, C. (eds) Principles of Molecular Medicine. Humana Press. https://doi.org/10.1007/978-1-59259-963-9_22
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DOI: https://doi.org/10.1007/978-1-59259-963-9_22
Publisher Name: Humana Press
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