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Salvage Surgery After Chemoradiation Therapy

  • Chapter
Squamous Cell Head and Neck Cancer

Part of the book series: Current Clinical Oncology ((CCO))

Abstract

The past two decades have seen significant advances in the efficacy of combined chemotherapy and radiation in the management of advanced stage squamous cell carcinoma (SCC) of the head and neck. This is especially true for SCC of the oropharynx, hypopharynx, and larynx. Primary surgery for advanced T-stage tumors, despite sophisticated reconstruction of the surgical defect, may result in a significant impact on speech, swallowing, and respiration. Organ preservation protocols using definitive radiation with or without chemotherapy may provide an effective primary treatment while avoiding the functional and cosmetic morbidity associated with surgery.

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References

  1. Jorgensen K, Godballe C, Olfred H, et al. Cancer of the larynx: treatment results after primary radiotherapy with salvage surgery in a series of 1005 patients. Acta Oncol 2002; 41:69–72.

    Article  PubMed  Google Scholar 

  2. MacKenzie RG, Franssen E, Balogh JM, et al. Comparing treatment outcomes of radiotherapy and surgery in locally advanced carcinoma of the larynx: a comparison limited to patients eligible for surgery. Int J Radiat Oncol Biol Phys 2000; 47:65–71.

    Article  PubMed  CAS  Google Scholar 

  3. Weber RS, Berkey BA, Forastiere AA, et al. Outcome of salvage total laryngectomy following organ preservation therapy. Arch Otolaryngol Head Neck Surg 2003; 129:44–49.

    Article  PubMed  Google Scholar 

  4. Forastiere AA, Goepfert H, Maor M, et al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 2003; 349:2091–2098.

    Article  PubMed  CAS  Google Scholar 

  5. Lavertu P, Bonafede JP, Adelstein DJ, et al. Comparison of surgical complications after organ-preservation therapy in patients with stage III or IV squamous cell head and neck cancer. Arch Otolaryngol Head Neck Surg 1998; 124:401–406.

    PubMed  CAS  Google Scholar 

  6. Lavertu P, Adelstein DJ, Saxton JP, et al. Aggressive concurrent chemoradiotherapy for squamous cell head and neck cancer: an 8-year single-institution experience. Arch Otolaryngol Head Neck Surg 1999; 125:142–148.

    PubMed  CAS  Google Scholar 

  7. Adelstein DJ, Saxton JP, Lavertu P, et al. Maximizing local control and organ preservation in stage IV squamous cell head and neck cancer with hyperfractionated radiation and concurrent chemotherapy. J Clin Oncol 2002; 20:1405–1410.

    Article  PubMed  Google Scholar 

  8. Laccourreye O, Laccourreye L, Muscatello L, et al. Local failure after supracricoid partial laryngectomy: symptoms, management, and outcome. Laryngoscope 1998; 108:339–344.

    Article  PubMed  CAS  Google Scholar 

  9. Gehanno P, Depondt J, Guedon C, et al. Primary and salvage surgery for cancer of the tonsillar region: a retrospective study of 120 patients. Head Neck 1993; 15:185–189.

    Article  PubMed  CAS  Google Scholar 

  10. Yuen APW, Wei WI, Ho CM. Results of surgical salvage for radiation failures of laryngeal carcinoma. Otolaryngol Head Neck Surg 1995; 112:405–409.

    Article  PubMed  CAS  Google Scholar 

  11. Adelstein DJ, Li Y, Adams GL, et al. An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J Clin Oncol 2003; 21:92–98.

    Article  PubMed  Google Scholar 

  12. Mercado G, Adelstein DJ, Saxton JP, et al. Hypothyroidism: a frequent event after radiotherapy and after radiotherapy with chemotherapy for patients with head and neck carcinoma. Cancer 2001; 92:2892–2897.

    Article  PubMed  CAS  Google Scholar 

  13. Davidson J, Briant D, Gullane P, et al. The role of surgery following radiotherapy failure for advanced laryngopharyngeal cancer: a prospective study. Arch Otolaryngol Head Neck Surg 1994; 120:269–276.

    PubMed  CAS  Google Scholar 

  14. Teknos TN, Myers LL, Bradford CR, et al. Free tissue reconstruction of the hypopharynx after organ preservation therapy: analysis of wound complications. Laryngoscope 2001; 111:1192–1196.

    Article  PubMed  CAS  Google Scholar 

  15. Wei F, Celik N, Yang W, et al. Complications after reconstruction by plate and soft-tissue free flap in composite mandibular defects and secondary salvage reconstruction with osteocutaneous flap. Plast Reconstr Surg 2003; 112:37–42.

    Article  PubMed  Google Scholar 

  16. Terrell JE, Ronis DL, Fowler KE, et al. Clinical predictors of quality of life in patients with head and neck cancer. Arch Otolaryngol Head Neck Surg 2004; 130:401–408.

    Article  PubMed  Google Scholar 

  17. Lavertu P, Adelstein DJ, Saxton JP, et al. Management of the neck in a randomized trial comparing concurrent chemotherapy and radiotherapy with radiotherapy alone in respectable stage III and IV squamous cell head and neck cancer. Head Neck 1997; 19:559–566.

    Article  PubMed  CAS  Google Scholar 

  18. Peters LJ, Weber RS, Morrison WH, et al. Neck surgery in patients with primary oropharyngeal cancer treated by radiotherapy. Head Neck 1996; 18:552–559.

    Article  PubMed  CAS  Google Scholar 

  19. Narayan K, Crane CH, Kleid S, et al. Planned neck dissection as an adjunct to the management of patients with advanced neck disease treated with definitive radiotherapy: for some or for all? Head Neck 1999; 21:606–613.

    Article  PubMed  CAS  Google Scholar 

  20. Mendenhall WM, Villaret DB, Amdur RJ, et al. Planned neck dissection after definitive radiotherapy for squamous cell carcinoma of the head and neck. Head Neck 2002; 24:1012–1018.

    Article  PubMed  Google Scholar 

  21. Hoffman HT. Planned neck dissection after definitive radiotherapy for squamous cell carcinoma of the head and neck. Head Neck 2002; 24:1012–1018.

    Article  Google Scholar 

  22. Fritz MA, Esclamado RM, Lorenz RR, et al. Recurrent rates after selective neck dissection in the N0 irradiated neck. Arch Otolaryngol Head Neck Surg 2002; 128:292–5.

    PubMed  Google Scholar 

  23. Sassler AM, Esclamado RM, Wolf GT. Surgery after organ preservation therapy: analysis of wound complications. Arch Otolaryngol Head Neck Surg 1995; 121:162–165.

    PubMed  CAS  Google Scholar 

  24. Krause DH, Pfister DG, Harrison LB, et al. Salvage laryngectomy for unsuccessful larynx preservation therapy. Otol Rhino Laryngol 1995; 104:936–941.

    Google Scholar 

  25. Hall FT, O’Brien CJ, Clifford AR, et al. Clinical outcome following total laryngectomy for cancer. ANZ J Surg 2003; 73:300–305.

    Article  PubMed  Google Scholar 

  26. Davidson J, Keane T, Brown D, et al. Surgical salvage after radiotherapy for advanced laryngopharyngeal carcinoma. Arch Otolaryngol Head Neck Surg 1997; 123:420–424.

    PubMed  CAS  Google Scholar 

  27. Agra IM, Carvalho AL, Pontes E, et al. Postoperative complications after en bloc salvage surgery for head and neck cancer. Arch Otolaryngol Head Neck Surg 2003; 129:1317–1321.

    Article  PubMed  Google Scholar 

  28. Parsons JT, Mendelhall WM, Stringer SP, et al. Salvage surgery following radiation failure in squamous cell carcinoma of the supraglottic larynx. Int J Radiat Oncol Biol Phys 1995; 32:605–609.

    Article  PubMed  CAS  Google Scholar 

  29. Yuen AP, Ho CM, Wei WI, et al. Prognosis of recurrent laryngeal carcinoma after laryngectomy. Head Neck 1995; 17:526–530.

    Article  PubMed  CAS  Google Scholar 

  30. Stoeckli SJ, Pawlik AB, Lipp M, et al. Salvage surgery after failure of nonsurgical therapy for carcinoma of the larynx and hypopharynx. Arch Otolaryngol Head Neck Surg 2000; 126:1473–1477.

    PubMed  CAS  Google Scholar 

  31. Jones AS. The management of early hypopharyngeal cancer: Primary radiotherapy and salvage surgery. Clin Otolaryngol 1992; 17:545–549.

    Article  PubMed  CAS  Google Scholar 

  32. Chan AW, Ancukeiwicz M, Carballo N, et al. The role of postradiotherapy neck dissection in supraglottic carcinoma. Int J Radiat Oncol Biol Phys 2001; 50:367–375.

    Article  PubMed  CAS  Google Scholar 

  33. Mabanta SR, Mendenhall WM, Stringer SP, et al. Salvage treatment for neck recurrence after irradiation alone for head and neck squamous cell carcinoma with clinically positive neck nodes. Head Neck 1999; 21:591–594.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Head and Neck Institute, Cleveland Clinic Foundation, Cleveland, OH

    Walter T. Lee MD & Ramon M. Esclamado MD

Authors
  1. Walter T. Lee MD
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  2. Ramon M. Esclamado MD
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Editor information

Editors and Affiliations

  1. Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Cleveland, OH

    David J. Adelstein MD

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© 2005 Humana Press Inc., Totowa, NJ

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Lee, W.T., Esclamado, R.M. (2005). Salvage Surgery After Chemoradiation Therapy. In: Adelstein, D.J. (eds) Squamous Cell Head and Neck Cancer. Current Clinical Oncology. Humana Press. https://doi.org/10.1007/978-1-59259-938-7_5

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  • DOI: https://doi.org/10.1007/978-1-59259-938-7_5

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-473-9

  • Online ISBN: 978-1-59259-938-7

  • eBook Packages: MedicineMedicine (R0)

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