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Transcriptional Regulation of Angiogenesis

  • Peter Oettgen
Chapter
Part of the Contemporary Cardiology book series (CONCARD)

Abstract

Until recently, the transcription factors necessary for regulating vascular development were largely unknown. This is in sharp contrast with other developmental processes, such as hematopoiesis and myogenesis, in which several cell- or tissue-specific transcription factors have been identified. Vascular development requires the differentiation of endothelial cells from pluripotent stem cells. Progress in identifying the molecular mechanisms underlying vascular development has lagged considerably, in large part the model systems for studying vascular blood vessel development are more limited. The identification of several vascular-specific genes involved in vasculogenesis and the genomic regulatory regions required for directing their expression over the past decade has facilitated the identification of the transcriptional mechanisms required for vascular-specific gene expression. Targeted disruption of additional transcription factors that have been associated with vascular defects led to the elucidation of a role for these factors in vascular development. Angiogenesis, the development of additional blood vessels from a primary vascular network, may recapitulate many of the molecular events occurring during vascular development.

Keywords

Vascular Smooth Muscle Cell Vascular Development bHLH Transcription Factor Endothelial Differentiation Vascular Defect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Humana Press Inc., Totowa, NJ 2005

Authors and Affiliations

  • Peter Oettgen
    • 1
  1. 1.Division of Cardiology, Department of MedicineBeth Israel Deaconess Medical Center and Harvard Medical SchoolBoston

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