Skip to main content

Preventive Nutrition Throughout the Life Cycle

A Cost-Effective Approach to Improved Health

  • Chapter
Preventive Nutrition

Abstract

Key Points

  • More than 60% of adults in the United States self-report that they are in excellent health, although more than 60% are overweight or obese and almost 60% do not participate in any vigorous physical activity. Obesity is a growing problem globally.

  • A major finding in the 20th century was that a simple B vitamin (folic acid) could prevent a very serious birth defect of the neural tube; furthermore, folic acidcontaining multivitamins taken during the periconceptional period significantly reduced cardiovascular and renal defects as well as neural tube and cleft lip-cleft palate defects.

  • Low intakes of many of the essential micronutrients are associated with increased risk of low birth weight and/or premature births, maternal morbidity and mortality in both developed and undeveloped nations. Interventions have the potential to reduce health care costs by billions of dollars annually.

  • Childhood undernutrition, also seen in both developed and undeveloped nations, significantly reduces intellectual capacity and increases infection-related morbidity/mortality. Micronutrient fortification is predicted to be highly cost-effective.

  • Regarding adult chronic diseases/conditions, 5 of the 10 leading causes of death are related to diet. Although recent intervention trials with single or multiple micronutrients did not show decreases in secondary events, baseline findings continue to confirm the strong associations between higher than average intakes and significantly reduced risks of, for example, cancer and cardiovascular disease.

  • Osteoporosis, cataracts, age-related macular degeneration, diabetes, and hypertension appear to be likely candidates for preventive nutrition intervention strategies. Predicted annual cost savings above and beyond the costs for the nutritional interventions could reach $50 billion.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Deckelbaum RJ, Fisher EA, Winston M, et al. Summary of a Scientific Conference on Preventive Nutrition: Pediatrics to Geriatrics. Circulation 1999; 100:450–456.

    CAS  Google Scholar 

  2. Beresford, S.A.A., Motulsky, A.G. Homocyst(e)ine, Folic Acid and Cardiovascular Disease Risk. In: Bendich A, Deckelbaum, RJ, eds. Preventive Nutrition: The Comprehensive Guide for Health Professionals, 3rd ed. Humana Press, Totowa, NJ, 2005.

    Google Scholar 

  3. Bostick RM. Diet and Nutrition in the Etiology and Primary Prevention of Colon Cancer. In: Bendich A, Deckelbaum, RJ, eds. Preventive Nutrition: The Comprehensive Guide for Health Professionals, 1st ed. Humana Press, Totowa, NJ, 1997, pp. 57–96.

    Google Scholar 

  4. Buring JE, Gaziano JM. Antioxidant Vitamins and Cardiovascular Disease. In: Bendich A, Deckelbaum, RJ, eds. Preventive Nutrition: The Comprehensive Guide for Health Professionals, 1st ed. Humana Press, Totowa, NJ, 1997, pp. 171–180.

    Google Scholar 

  5. Comstock GW, Helzlsouer KJ. Preventive Nutrition and Lung Cancer. In: Bendich A, Deckelbaum, RJ, eds. Preventive Nutrition: The Comprehensive Guide for Health Professionals, 1st ed. Humana Press, Totowa, NJ, 1997, pp. 109–134.

    Google Scholar 

  6. Fontham ETH. Prevention of Upper Gastrointestinal Tract Cancers. In: Bendich A, Deckelbaum, RJ, eds. Preventive Nutrition: The Comprehensive Guide for Health Professionals, 3rd ed. Humana Press, Totowa, NJ, 2005.

    Google Scholar 

  7. Hertog MG, Bueno-de-Mesquita HB, Fehily AM, Sweetnam PM, Elwood PC, Kromhout D. Fruit and vegetable consumption and cancer mortality in the Caerphilly Study. Cancer Epidemiol Biomark Prev 1996; 5:673–677..

    CAS  Google Scholar 

  8. Howe GR. Nutrition and Breast Cancer. In: Bendich A, Deckelbaum, RJ, eds. Preventive Nutrition: The Comprehensive Guide for Health Professionals, 1st ed. Humana Press, Totowa, NJ, 1997, pp. 97–108.

    Google Scholar 

  9. Joshipura KJ, Asherio A, Manson JE, Stampfer MJ, Rimm EB, Speizer FE, Hennelcero CH, Spiegelman D, Willett WC. Fruit and vegetable intake in relation to risk of ischemic stroke. JAMA 1999; 282:1233–1239.

    CAS  PubMed  Google Scholar 

  10. Kushi LH, Folsom AR, Prinaes RJ, Mink PJ, Ying W, Bostick RM. Dietary antioxidant vitamins and death from coronary heart disease in postmenopausal women. N Engl J Med 1996; 334:1156–1162,.

    CAS  PubMed  Google Scholar 

  11. Willett WC. Potential Benefits of Preventive Nutrition Strategies: Lessons for the United States. In: Bendich A, Deckelbaum, RJ, eds. Preventive Nutrition: The Comprehensive Guide for Health Professionals, 3rd ed. Humana Press, Totowa, NJ, 2005.

    Google Scholar 

  12. Jacobs DR, Meyer KA, Kushi LH, Folsom AR. Whole grain intake may reduce the risk of ischemic heart disease death in postmenopausal women: the Iowa Women’s Health Study. Am J Clin Nutr 1998; 68:248–257..

    CAS  PubMed  Google Scholar 

  13. Jacobs DRR, Marquart L, Slavin J, Kushi, LH. Whole grain intake and cancer: an expanded review and meta-analysis. Nutr Cancer 1998; 30:85–96.

    PubMed  Google Scholar 

  14. Jarvi AE, Karlstrom BE, Granfeldt YE, Bjorck IM, Vessby BO, Asp NG. The influence of food structure on postprandial metabolism in patients with non-insulin-dependent diabetes mellitus. Am J Clin Nutr 1995; 61(4):837–842.

    CAS  PubMed  Google Scholar 

  15. Dietary Guidelines Advisory Committee. Prepared for the Committee by the Agricultural Research Service, United States Department of Agriculture. Report of the Dietary Guidelines Advisory Committee on the Dietary Guidelines for Americans. 2000, p.1.

    Google Scholar 

  16. Liu S, Stampfer MJ, Hu FB, et al. Whole-grain consumption and risk of coronary heart disease: results from the Nurses’ Health Study. Am J Clin Nutr 1999; 70(3):412–419.

    CAS  PubMed  Google Scholar 

  17. McCarron DA, Heaney RP. Estimated healthcare savings associated with adequate dairy food intake. Am J Hypertension 2004; 17:88–97.

    Google Scholar 

  18. Frier HI, Greene HL. Obesity and Chronic Disease: Impact of Weight Reduction. In: Bendich A, Deckelbaum, RJ, eds. Preventive Nutrition: The Comprehensive Guide for Health Professionals, 3rd ed. Humana Press, Totowa, NJ, 2005.

    Google Scholar 

  19. Williams CL. Can Childhood Obesity be Prevented? Preschool nutrition and Obesity. In: Bendich A, Deckelbaum, RJ, eds. Preventive Nutrition: The Comprehensive Guide for Health Professionals, 3rd ed. Humana Press, Totowa, NJ, 2005.

    Google Scholar 

  20. Bergstrom E, Hernell O. Obesity and Insulin Resistance in Childhood and Adolescence. In: Bendich A, Deckelbaum, RJ, eds. Preventive Nutrition: The Comprehensive Guide for Health Professionals, 3rd ed. Humana Press, Totowa, NJ, 2005.

    Google Scholar 

  21. Faith MS, Calamaro CJ, Pietrobelli A, Dolan MS, Allison DV, Heymsfield SB. Prevention of Pediatric Obesity: Examining the Issues and Forecasting Research Directions. In: Bendich A, Deckelbaum, RJ, eds. Preventive Nutrition: The Comprehensive Guide for Health Professionals, 3rd ed. Humana Press, Totowa, NJ. 2005.

    Google Scholar 

  22. Kiess W, Bottner A, Bluher S, et al. Phamacoeconomics of obesity management in childhood and adolescence. Expert Opin Pharmacother 2003; 4(9):1471–1477.

    PubMed  Google Scholar 

  23. Holmes MD, Hunter DJ, Colditz GA, et al. Association of dietary intake of fat and fatty acids with risk of breast cancer. JAMA 1999; 281(10):914–920.

    CAS  PubMed  Google Scholar 

  24. Rozowski SJ, Moreno M. Effect of Westernization of Nutritional Habits on Obesity in Latin America. In: Bendich A, Deckelbaum, RJ, eds. Preventive Nutrition: The Comprehensive Guide for Health Professionals, 1st ed. Humana Press, Totowa, NJ, 1997, pp. 487–504.

    Google Scholar 

  25. Zhang S, Hunter DJ, Rosner BA, et al. Dietary fat and protein in relation to risk of non-Hodgkin’s lymphoma among women. J Natl Cancer Inst 1999; 91(20):1751–1758,.

    CAS  PubMed  Google Scholar 

  26. Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath CW Jr. Body-mass index and mortality in a prospective cohort of US adults. N Engl J Med 1999; 341(15):1097–1105,.

    CAS  PubMed  Google Scholar 

  27. Zhang S, Hunter DJ, Hankinson SE, et al. A prospective study of folate intake and the risk of breast cancer. JAMA 1999; 281(17):1632–1637.

    CAS  PubMed  Google Scholar 

  28. Brandle M, Zhou H, Smith BR, et al. The direct medical cost of type 2 diabetes. Diabetes Care 2003; 8:2300–2304.

    Google Scholar 

  29. Anderson R. Antioxidant Nutrients and Prevention of Oxidant-Mediated Diseases. In: Bendich A, Deckelbaum, RJ, eds. Preventive Nutrition: The Comprehensive Guide for Health Professionals, 3rd ed. Humana Press, Totowa, NJ, 2005

    Google Scholar 

  30. Blumberg J. Public Health Implications of Preventive Nutrition. In: Bendich A, Deckelbaum, RJ, eds. Preventive Nutrition: The Comprehensive Guide for Health Professionals, 1st ed. Humana Press, Totowa, NJ, 1997, pp. 1–17.

    Google Scholar 

  31. Krebs-Smith SM, Smicklas-Wright H, Guthrie HA, Krebs-Smith J. The effects of variety in food choices on dietary quality. J Am Diet Assoc 1987; 87:897–903,.

    CAS  PubMed  Google Scholar 

  32. Selhub J, Jacques PF, Rosenberg IH, et al. Serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey (1991–1994): population reference ranges and contribution of vitamin status to high serum concentrations. Ann Intern Med 1999; 131(5):331–339.

    CAS  PubMed  Google Scholar 

  33. Bendich A, Mallick R, Leader S. Potential health economic benefits of vitamin supplementation. West J Med 1997; 166(5):306–312.

    CAS  PubMed  Google Scholar 

  34. Ross GW, Petrovitch H, White LR, et al. Characterization of risk factors for vascular dementia: the Honolulu-Asia Aging Study. Neurology 1999; 53(2):337–343,.

    CAS  PubMed  Google Scholar 

  35. Spencer AP, Carson DS, Crouch MA. Vitamin E and coronary artery disease. Arch Intern Med 1999; 159(12):1313–1320.

    CAS  PubMed  Google Scholar 

  36. Bendich A, Deckelbaum, RJ, eds. Preventive Nutrition: The Comprehensive Guide for Health Professionals, 1st ed. Humana Press, Totowa, NJ, 1997.

    Google Scholar 

  37. Bendich A, Deckelbaum, RJ, eds. Preventive Nutrition: The Comprehensive Guide for Health Professionals, 2nd ed. Humana Press, Totowa, NJ, 2001.

    Google Scholar 

  38. Bendich A, Deckelbaum, RJ, eds. Primary and Secondary Preventive Nutrition, Humana Press, Totowa, NJ, 2001.

    Google Scholar 

  39. Czeizel AE. Folic Acid-Containing Multivitamins and Primary Prevention of Birth Defects. In: Bendich A, Deckelbaum, RJ, eds. Preventive Nutrition: The Comprehensive Guide for Health Professionals, 1st ed. Humana Press, Totowa, NJ, 1997, pp. 351–371.

    Google Scholar 

  40. Scholl TO, Hediger ML. Maternal Nutrition and Preterm Delivery. In: Bendich A, Deckelbaum, RJ, eds. Preventive Nutrition: The Comprehensive Guide for Health Professionals, 1st ed. Humana Press, Totowa, NJ, 1997, pp. 405–421.

    Google Scholar 

  41. Woodall AA, Ames BN. Nutritional Prevention of DNA Damage to Sperm and Consequent Risk Reduction in Birth Defects and Cancer in Offspring. In: Bendich A, Deckelbaum, RJ, eds. Preventive Nutrition: The Comprehensive Guide for Health Professionals, 1st ed. Humana Press, Totowa, NJ, 1997, pp. 373–385.

    Google Scholar 

  42. Barker DJ. Fetal origins of cardiovascular disease. Ann Med 1999; 1:3–6.

    Google Scholar 

  43. Klebanoff MA, Secher NJ. Mednick BR, Schulsinger C. Maternal size at birth and the development of hypertension during pregnancy: a test of the Barker hypothesis. Arch Intern Med 1999; 159(14):1607–1612.

    CAS  PubMed  Google Scholar 

  44. Moore SE. Nutrition, immunity and the fetal and infant origins of disease hypothesis in developing countries. Proc Nutr Soc 1998; 57:241–247,.

    CAS  PubMed  Google Scholar 

  45. Yarbrough DE, Barrett-Connor E, Kritz-Silverstein D, Wingard DL. Birth weight, adult weight, and girth as predictors of the metabolic syndrome in postmenopausal women–the Rancho Bernardo Study. Diabetes Care 1998; 21:1652–1658,.

    CAS  PubMed  Google Scholar 

  46. Czeizel AE. Folic Acid-Containing Multivitamins and Primary Prevention of Birth Defects. Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary. In: Bendich A, Deckelbaum, RJ, eds. Preventive Nutrition, 3rd ed., Humana Press, Totowa, NJ, 2005.

    Google Scholar 

  47. Czeizel AE, Dudas I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 1992; 327(26):1832–1835.

    CAS  PubMed  Google Scholar 

  48. MRC. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group. Lancet 1991; 338(8760):13–17.

    Google Scholar 

  49. Botto LD, Khoury MJ, Mulinare J, Erickson JD. Periconceptional multivitamin use and the occurrence of conotruncal heart defects: results from a population-based, case-control study. Pediatrics: 1996; 98(5):911–917.

    CAS  PubMed  Google Scholar 

  50. MMWR. Use of folic acid-containing supplements among women of childbearing age-United States, 1997. MMWR 1998; 47:131–134,.

    Google Scholar 

  51. Butterworth CE, Bendich A. Folic acid and the prevention of birth defects. Ann Rev Nutr 1996; 16:73–98,.

    CAS  Google Scholar 

  52. Bunin GR, Cary JM. Diet and Childhood Cancer: Preliminary Evidence. In: Bendich A, Deckelbaum, RJ, eds. Preventive Nutrition: The Comprehensive Guide for Health Professionals, 1st ed. Humana Press, Totowa, NJ, 1997, pp. 17–32.

    Google Scholar 

  53. Oakley GP Jr. Eat right and take a vitamin. N Engl J Med 1998; 338(15):1060,1061.

    PubMed  Google Scholar 

  54. Berry RJ, Li Z, Erickson JD, et al. Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention. N Engl J Med 1999; 341(20):1485–1490.

    CAS  PubMed  Google Scholar 

  55. MMWR. Preterm singleton births—United States, 1989–1996. MMWR. 1999; 48:185–189.

    Google Scholar 

  56. Polhamus B, Dalenius K, Thompson D, et al. Pediatric nutrition surveillance. Nutr Clin Care 2003; 6(3):132–134.

    CAS  PubMed  Google Scholar 

  57. Scholl TO, Hediger ML, Bendich A, Schall JI, Smith WK, Krueger PM. Use of multivitamin/mineral prenatal supplements: influence on the outcome of pregnancy. Am J Epidemiol 1997; 146:134–141.

    CAS  PubMed  Google Scholar 

  58. Goldenberg RL, Tamura T, Neggers Y, et al. The effect of zinc supplementation on pregnancy outcome. JAMA 1995; 274(6):463–468.

    CAS  PubMed  Google Scholar 

  59. Scholl TO. Maternal Nutrition and Preterm Delivery. UMDNJ. Camden, NJ. In: Bendich A, Deckelbaum, RJ, eds. Preventive Nutrition, 3rd ed. Humana Press, Totowa, NJ, 2005.

    Google Scholar 

  60. deOnis M, Villar J, Gulmezoglu M. Nutritional interventions to prevent intrauterine growth retardation: evidence from randomized controlled trials. Eur J Clin Nutr 1998; 53(1):S83–S93,.

    Google Scholar 

  61. Ramakrishnan U, Manjrekar R, Rivera J, Gonzales-Cossio T, Martorell R. Micronutrients and pregnancy outcome: a review of the literature. Nutr Res 1999; 19:103–159.

    CAS  Google Scholar 

  62. West KP Jr, Katz J, Khatry SK, et al. Double blind, cluster randomised trial of low dose supplementation with vitamin A or beta carotene on mortality related to pregnancy in Nepal. The NNIPS-2 Study Group. BMJ 1999; 318(7183): 570–575.

    CAS  PubMed  Google Scholar 

  63. Fawzi WW, Masamanga GI, Speigelman D, et al. Randomised trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1 infected women in Tanzania. Lancet 1998; 351(9114):1477–1482.

    CAS  PubMed  Google Scholar 

  64. Ramakrishnan U. Nutrition and low birth weight: from research to practice. Am J Clin Nutr 2004; 79:17–21.

    CAS  PubMed  Google Scholar 

  65. Chappell LC, Seed PT, Bailey Al, et al. Effects of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomized trial. Lancet 1999; 254:810–816.

    Google Scholar 

  66. DerSimonian R, Levine RL. Resolving discrepancies between a meta-analysis and a subsequent large controlled trial. JAMA 1999; 282:664–670.

    CAS  PubMed  Google Scholar 

  67. Levine RJ, Hauth JC, Curet LB, et al. Trial of calcium to prevent preeclampsia. N Engl J Med 1997; 337(2):69–76.

    CAS  PubMed  Google Scholar 

  68. Bucher HC, Guyatt GH, Cook RJ, et al. Effect of calcium supplementation on pregnancy-induced hypertension and preeclampsia: a meta-analysis of randomized controlled trials. JAMA 1996; 275(14):1113–1117,.

    CAS  PubMed  Google Scholar 

  69. Anonymous. Optimal calcium intake. NIH consensus development panel. JAMA 1994; 272:1942–1948.

    Google Scholar 

  70. Institute of Medicine Food and Nutrition Board. Dietary Reference Intakes for Calcium, Phosphorous, Magnesium, Vitamin D, and Fluoride. National Academy Press, Washington DC, 1997, S9.

    Google Scholar 

  71. Crowther CA, Hiller JE, Pridmore B, et al. Calcium supplementation in nulliparous women for the prevention of pregnancy-induced hypertension, preeclampsia and preterm birth: an Australian randomized trial. FRACOG and the ACT Study Group. Aust NZ J Obstet Gynaecol 1999; 39:12–18.

    CAS  Google Scholar 

  72. Belizan JM, Villar J, Bergel E, et al. Long-term effect of calcium supplementation during pregnancy on the blood pressure of offspring: follow up of a randomised controlled trial. BMJ 1997; 315(7103):281–285.

    CAS  PubMed  Google Scholar 

  73. Wang YP, Walsh SW, Guo JD, Zhang JY. Maternal levels of prostacyclin, thromboxane, vitamin E, and lipid peroxides throughout normal pregnancy. Am J Obstet Gynecol 1991; 165:1690–1694.

    CAS  PubMed  Google Scholar 

  74. Jain SK, Wise R. Relationship between elevated lipid peroxides, vitamin E deficiency and hypertension in preeclampsia. Mol Cell Biochem 1995; 151:33–38.

    CAS  PubMed  Google Scholar 

  75. Hughes D, Bryan J. The assessment of cognitive performance in children: considerations for detecting nutritional influences. Nut Rev 2003; 61:413–422.

    Google Scholar 

  76. Drewnowski A, Specter SE. Poverty and obesity: the role of energy density and energy costs. Am J Clin Nutr 2004; 79:6–16.

    CAS  PubMed  Google Scholar 

  77. Ernst ND, McGinnis MJ. Preventive Nutrition: A Historic Perspective and Future Economic Outlook. NHLBI—NIH and RW Johnson Foundation. Preventive Nutrition: The Comprehensive Guide for Health Professionals, 3rd ed. Human Press, Totowa, NJ, 2005..

    Google Scholar 

  78. Goldstein DJ. The Management of Eating Disorders and Obesity, 2nd ed. Humana Press, Totowa, NJ, 2005.

    Google Scholar 

  79. Hodis HN, Mack WJ, Sevanian A. Antioxidant Vitamin Supplementation and Cardiovascular Disease. In: Bendich A, Deckelbaum, RJ, eds. Preventive Nutrition, The Comprehensive Guide for Health Professionals, 3rd ed. Humana Press, Totowa, NJ, 2004.

    Google Scholar 

  80. Fassbender K, Mielke O, Bertsch T, Nafe B, Froschen S, Hennerici M. Homocysteine in cerebral macroangiography and microangiopathy. Lancet 1999; 353(9164):1586,1587.

    CAS  PubMed  Google Scholar 

  81. Ridker PM, Manson JE, Buring JE, Shih J, Matias M, Hennekens CH. Homocysteine and risk of cardiovascular disease among postmenopausal women. JAMA 1999; 281(19):1817–1821.

    CAS  PubMed  Google Scholar 

  82. Jacques PF, Selhub J, Bostom AG, Wilson PW, Rosenberg IH. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med 1999; 340(19):1449–1454.

    CAS  PubMed  Google Scholar 

  83. Toole JF, Malinow MR, Chambless LE, et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) Randomized Controlled Trial. JAMA 2004; 291(5):565,.

    CAS  PubMed  Google Scholar 

  84. Blair SN, Brodney S. Effects of physical inactivity and obesity on morbidity and mortality: current evidence and research issues. Med Sci Sports Exerc 1999; 11(Suppl):S646–S662.

    Google Scholar 

  85. McTiernan A, Schwartz RS, Potter J, Bowen D. Exercise clinical trials in cancer prevention research: a call to action. Cancer Epidemiol Biomarkers Prev 1999; 8(3):201–207.

    CAS  PubMed  Google Scholar 

  86. Pols MA, Peeters PH, Twisk JW, Kemper HC, Grobbee DE. Physical activity and cardiovascular disease risk profile in women. Am J Epidemiol 1997; 146(4):322–328.

    CAS  PubMed  Google Scholar 

  87. Baron JA, Beach M, Mandel JS, et al. Calcium supplements for the prevention of colorectal adenomas. Calcium Polyp Prevention Study Group. N Engl J Med 1999; 340(2):101–107.

    CAS  PubMed  Google Scholar 

  88. McCarron DA, Reusser ME. Finding consensus in the dietary calcium-blood pressure debate. J Am Coll Nutr 1999; 18:398S–405S,.

    CAS  PubMed  Google Scholar 

  89. Looker AC, Orwoll ES, Johnston CC, et al. Prevalence of low femoral bone density in older US adults from NHANES III. J Bone Miner Res 1997; 12(11):1761–1768.

    CAS  PubMed  Google Scholar 

  90. Heaney RP. Osteoporosis: Vitamins, Minerals, and Other Micronutrients. In: Bendich A, Deckelbaum, RJ, eds. Preventive Nutrition: The Comprehensive Guide for Health Professionals, Humana Press, 1st ed. Totowa, NJ, 1997, pp. 285–302.

    Google Scholar 

  91. Holick MF, ed. Vitamin D. Humana Press, Totowa, NJ, 1999.

    Google Scholar 

  92. Marshall D, Johnell O, Wedel H. Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ 1996; 312:1254–1259.

    CAS  PubMed  Google Scholar 

  93. Kleerekoper M, Avioli L. Evaluation and Treatment of Postmenopausal Osteoporosis. In: Favus M, ed. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. Lippincott-Raven, Philadelphia, PA, 1996, pp. 264–271.

    Google Scholar 

  94. Chapuy M, Arlot M, Duboeuf F, et al. Vitamin D3 and calcium to prevent hip fractures in elderly women. New Eng J Med 1992; 327(23):1637–1642.

    CAS  PubMed  Google Scholar 

  95. Dawson-Hughes B, Harris S, Krall E, Dallal G. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. New Eng J Med 1997; 337(10):670–676.

    CAS  PubMed  Google Scholar 

  96. Reid I, Ames R, Evans M, Gamble G, Sharpe S. Long-term effects of calcium supplementation on bone loss and fractures in post-menopausal women: a randomized controlled trial. Am J Med 1995; 98:331–335.

    CAS  PubMed  Google Scholar 

  97. Bendich A, Leader S, Muhuri P. Supplemental calcium for the prevention of hip fracture: potential health-economic benefits. Clin Ther 1999; 21(6):1058–1072.

    CAS  PubMed  Google Scholar 

  98. Recker RR, Hinders S, Davies KM, et al. Correcting calcium nutritional deficiency prevents spine fractures in elderly women. J Bone Miner Res 1996; 11:1961–1966.

    CAS  PubMed  Google Scholar 

  99. Nieves JW, Komar L, Cosman F, Lindsay R. Calcium potentiates the effect of estrogen and calcitonin on bone mass: review and analysis. Am J Clin Nutr 1998; 67(1):18–24.

    CAS  PubMed  Google Scholar 

  100. Elbon S, Johnson M, and Fischer J. Milk consumption in older Americans. Am J Pub Health 1998; 88:1221–1224.

    CAS  Google Scholar 

  101. LeBoff MS, Kohlmeier L, Hurwitz S, Franklin J, Wright J, Glowacki J. Occult vitamin D deficiency in postmenopausal US women with acute hip fracture. JAMA 1999; 281(16):1505–1511.

    CAS  PubMed  Google Scholar 

  102. Singer BR, McLauchlan GJ, Robinson CM, Christie J. Epidemiology of fractures in 15,000 adults: the influence of age and gender. J Bone Joint Surg Br 1998; 80(2):243–248.

    CAS  PubMed  Google Scholar 

  103. Melhus H, Michaelsson K, Holmberg L, Wolk A, Ljunghall S. Smoking, antioxidant vitamins, and the risk of hip fracture. J Bone Miner Res 1999; 14(1):129–135.

    CAS  PubMed  Google Scholar 

  104. Krall EA, Dawson-Hughes B. Smoking and bone loss among postmenopausal women. J Bone Miner Res 1991; 6:331–338.

    CAS  PubMed  Google Scholar 

  105. Jones G, Riley M, Dwyer T. Maternal smoking during pregnancy, growth, and bone mass in prepubertal children. J Bone Miner Res 1999; 1:146–151.

    Google Scholar 

  106. Koo WWK, Walters JC, Esterlitz J, Levine RJ, Bush AJ, Sibai B. Maternal calcium supplementation and fetal bone mineralization. Obstet Gynecol. 1999; 94:577–582.

    CAS  PubMed  Google Scholar 

  107. Siegal M, Chin C-J, Tayler A. Antioxidant Status and Risk for Cataract. In: Bendich A, Deckelbaum, RJ, eds. Preventive Nutrition, 3rd ed. Humana Press, Totowa, NJ, 2005.

    Google Scholar 

  108. Nappo F, De Rosa N, Marfella R, et al. Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins. JAMA 1999; 281(22):2113–2118.

    CAS  PubMed  Google Scholar 

  109. Woodside JV, Young IS, Yarnell JW, et al. Antioxidants, but not B-group vitamins increase the resistance of low-density lipoprotein to oxidation: a randomized, factorial design, placebo-controlled trial. Atherosclerosis 1999; 144(2):419–427.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Humana Press Inc.

About this chapter

Cite this chapter

Bendich, A., Deckelbaum, R.J. (2005). Preventive Nutrition Throughout the Life Cycle. In: Bendich, A., Deckelbaum, R.J. (eds) Preventive Nutrition. Nutrition and Health. Humana Press. https://doi.org/10.1007/978-1-59259-880-9_37

Download citation

  • DOI: https://doi.org/10.1007/978-1-59259-880-9_37

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-445-6

  • Online ISBN: 978-1-59259-880-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics