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Coronary Artery Development

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Principles of Molecular Cardiology

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

Lineage mapping studies have shown an extracardiac origin for the coronary vasculature. Mesothelial cells arising from septum transversum mesenchyme contact the developing myocardium via a transient structure called the proepicardial organ (PEO). Proepicardial cells first extend over the surface of the heart to form the epicardial layer. Then, a subset of epicardial cells transform from epithelial to mesenchymal cells, migrate into the myocardial wall, and serve as progenitor cells for formation of the coronary vessels. Epicardial-derived mesenchymal cells (EPDCs) produce soluble factors that stimulate proliferation of myocardial cells in the compact zone of ventricular myocardium. Genetic studies have begun to identify the molecules that control and coordinate this complex process that ensures adequate perfusion of the myocardium during development of the heart.

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Authors and Affiliations

  1. Departments of Medicine and Genetics, Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, Chapel Hill, NC

    Mark W. Majesky PhD

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  1. Mark W. Majesky PhD
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Editors and Affiliations

  1. Department of Medicine, UNC School of Medicine, Chapell Hill, NC

    Marschall S. Runge MD, PhD

  2. Carolina Cardiovascular Biology Center, Chapel Hill, NC

    Cam Patterson MD

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Majesky, M.W. (2005). Coronary Artery Development. In: Runge, M.S., Patterson, C. (eds) Principles of Molecular Cardiology. Contemporary Cardiology. Humana Press. https://doi.org/10.1007/978-1-59259-878-6_11

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