The Role of the Insulin-Like Growth Factor System in Pre- and Postnatal Growth, Development, and Tumorigenesis
IGF action is an important regulator of pre- and postnatal growth in both experimental animals and in humans.
The complexity of the IGF signaling system of ligands, receptors, and binding proteins and their developmental and tissue-specific patterns of expression affords a powerful and finely orchestrated control mechanism throughout the life of the organism.
As a result of its ability to control growth and cell survival, the IGF system has the ability to affect, and has been implicated in, tumorigenesis in many types of cancer.
The IGF system has many components and aspects that make it an attractive therapeutic target for treatment of a number of disorders, including those affecting growth, cancer, and diabetes.
KeywordsProstate Cancer Risk Hybrid Receptor Ventral Prostate Weight
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