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The Insulin-Like Growth Factors and Assessment of Nutritional Status

  • M. Sue Houston
Chapter
Part of the Nutrition and Health book series (NH)

Abstract

  • The regulation of circulating IGF-I and IGFBPs by nutritional intake and the short half-life of these proteins in circulation offer great potential for the IGF proteins to be utilized as exceptionally sensitive acute biochemical markers of nutritional intake, repletion, and metabolic status.

  • The value of serum IGF-I as an indicator of short-term response to nutrional intervention has been described in a wide variety of patient populations and experimental conditions.

  • The sensitivity and specificity of serum IGF-I as a marker of nutritional status in critical illness is much greater than other visceral markers such as albumin, retinol binding protein, or transthyretin. Continued validation of IGF-I and IGFBPs in critical illness and other acute disorders is anticipated since assessment of appropriate nutritional intervention is both exceedingly important and particularly challenging in these circumstances.

  • Because of the acute nature of the response to nutrition, IGFs are much less suited to evaluating chronic nutritional status, body weight, or body composition.

  • The dependence of IGF proteins on vitamins, minerals, and other dietary constituents has been less fully investigated; however, deficiencies of specific nutrients clearly influence IGF protein synthesis and concentrations in the serum.

  • The IGFBPs, in particular IGFBP-1, IGFBP-2, and perhaps ratios of the IGFBPs and IGF-I, or free IGF-I in relation to nutrition, await further study, but could prove to be valuable markers of nutritional status.

Keywords

Growth Hormone Anorexia Nervosa Nutritional Assessment Protein Energy Malnutrition Somatomedin Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 2004

Authors and Affiliations

  • M. Sue Houston

There are no affiliations available

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